iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046360

UUCD1 version

UUC-HoS-00747

Ensembl Protein ID

ENSP00000245663.3

UniProt Accession

Q86UZ6; E1P5K9; Q5JWJ3; Q6GMV4; Q9BQK3; Q9H3Z8; Q9H3Z9; ZBT46_HUMAN

Genbank Protein ID

CAI21885.1; EAW75205.1; EAW75206.1; AAH52269.1; AAH73800.1

Protein Name

Zinc finger and BTB domain-containing protein 46; BTB-ZF protein expressed in effector lymphocytes; BTB/POZ domain-containing protein 4; Zinc finger protein 340

Genbank Nucleotide ID

AL121845; CH471077; CH471077; BC052269; BC073800

Gene Name

ZBTB46; BTBD4; ZNF340

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000130584.10	ENST00000245663.8	ENSP00000245663.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.90e-11	45.8	31	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv++vv+g++f+ahk vL  sS++F+ l  +  + s++   +++ d v ++ f+a+++F+Y+  l +
   Q: 31   CDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHL-DiVTAQGFKAIIDFMYSAHLAL 97
           9*****************************887777763444444.66**************998865 PP

Organism

Homo sapiens

Functional Description
(View)

Function as a transcriptional repressor for PRDM1.

Protein Sequence
(Fasta)

MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY 60
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGGACGGA CGGACGGACC GAGCAGCCCC GGCGAGCGCG CAGCTCGGAC CCGCCCGGAC 60
GCAGCGCCCT CCCGGCGGCG GCGGCGATCA CCGGCGCCGG CCCGGCGGCC GCGGCGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:2001199--P:negative regulation of dendritic cell differentiation
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0045650--P:negative regulation of macrophage differentiation
GO:0045656--P:negative regulation of monocyte differentiation
GO:2001200--P:positive regulation of dendritic cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:140685

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002267	Ailuropoda melanoleuca	90.11	0.00e+00	920.00
IUUC-Apl-004220	Anas platyrhynchos	85.03	0.00e+00	957.00
IUUC-Aca-005350	Anolis carolinensis	76.79	0.00e+00	932.00
IUUC-Ame-011334	Astyanax mexicanus	61.01	0.00e+00	716.00
IUUC-Bta-012773	Bos taurus	85.47	0.00e+00	941.00
IUUC-Cja-019261	Callithrix jacchus	84.32	0.00e+00	899.00
IUUC-Cfa-021070	Canis familiaris	91.65	0.00e+00	765.00
IUUC-Cpo-021350	Cavia porcellus	92.62	0.00e+00	1013.00
IUUC-Csa-023182	Chlorocebus sabaeus	98.64	0.00e+00	1075.00
IUUC-Cin-025354	Ciona intestinalis	40.17	1.00e-22	102.00
IUUC-Csv-026323	Ciona savignyi	40.00	2.00e-23	104.00
IUUC-Dre-027453	Danio rerio	62.46	0.00e+00	729.00
IUUC-Dno-029375	Dasypus novemcinctus	86.25	0.00e+00	687.00
IUUC-Dor-030991	Dipodomys ordii	74.16	0.00e+00	770.00
IUUC-Eca-033346	Equus caballus	91.21	0.00e+00	988.00
IUUC-Eeu-034489	Erinaceus europaeus	84.77	0.00e+00	711.00
IUUC-Fca-035853	Felis catus	89.10	0.00e+00	973.00
IUUC-Fal-037546	Ficedula albicollis	83.52	0.00e+00	932.00
IUUC-Gmo-038589	Gadus morhua	83.33	1.00e-72	265.00
IUUC-Gga-040354	Gallus gallus	84.50	0.00e+00	939.00
IUUC-Ggo-045007	Gorilla gorilla	99.63	0.00e+00	1067.00
IUUC-Itr-048566	Ictidomys tridecemlineatus	84.86	0.00e+00	976.00
IUUC-Lch-050668	Latimeria chalumnae	74.54	0.00e+00	862.00
IUUC-Loc-052410	Lepisosteus oculatus	68.46	0.00e+00	801.00
IUUC-Laf-054523	Loxodonta africana	89.14	0.00e+00	953.00
IUUC-Mcc-055030	Macaca mulatta	99.01	0.00e+00	1020.00
IUUC-Meu-056772	Macropus eugenii	82.20	0.00e+00	997.00
IUUC-Mga-059531	Meleagris gallopavo	83.03	0.00e+00	914.00
IUUC-Mmr-061653	Microcebus murinus	89.81	0.00e+00	1023.00
IUUC-Mdo-062023	Monodelphis domestica	81.24	0.00e+00	1001.00
IUUC-Mmu-063957	Mus musculus	87.69	0.00e+00	1038.00
IUUC-Mpu-065784	Mustela putorius furo	87.52	0.00e+00	970.00
IUUC-Mlu-067188	Myotis lucifugus	86.33	0.00e+00	944.00
IUUC-Nle-069839	Nomascus leucogenys	97.29	0.00e+00	963.00
IUUC-Ont-071549	Oreochromis niloticus	67.52	0.00e+00	714.00
IUUC-Oan-073288	Ornithorhynchus anatinus	78.71	0.00e+00	987.00
IUUC-Ocu-074031	Oryctolagus cuniculus	66.61	0.00e+00	692.00
IUUC-Ola-087013	Oryzias latipes	66.55	0.00e+00	711.00
IUUC-Oga-089158	Otolemur garnettii	89.30	0.00e+00	984.00
IUUC-Oar-090145	Ovis aries	82.05	0.00e+00	778.00
IUUC-Ptr-090525	Pan troglodytes	98.98	0.00e+00	1063.00
IUUC-Pan-092450	Papio anubis	98.81	0.00e+00	1069.00
IUUC-Psi-093791	Pelodiscus sinensis	79.90	0.00e+00	971.00
IUUC-Pfo-096728	Poecilia formosa	63.06	0.00e+00	696.00
IUUC-Pab-098690	Pongo abelii	98.97	0.00e+00	986.00
IUUC-Pva-103107	Pteropus vampyrus	84.80	0.00e+00	688.00
IUUC-Rno-104885	Rattus norvegicus	87.38	0.00e+00	1030.00
IUUC-Sha-107445	Sarcophilus harrisii	81.07	0.00e+00	998.00
IUUC-Sar-113744	Sorex araneus	79.36	9.00e-174	602.00
IUUC-Tgu-117181	Taeniopygia guttata	83.52	0.00e+00	936.00
IUUC-Tru-117668	Takifugu rubripes	61.64	0.00e+00	708.00
IUUC-Tsy-119528	Tarsius syrichta	92.46	3.00e-166	578.00
IUUC-Tni-120403	Tetraodon nigroviridis	82.39	2.00e-66	246.00
IUUC-Tbe-128061	Tupaia belangeri	73.46	2.00e-168	584.00
IUUC-Ttr-128681	Tursiops truncatus	90.34	0.00e+00	829.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence