iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132742

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M

Genbank Nucleotide ID

BC061289

Gene Name

ube2m; ubc12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000018326.2	ENSXETT00000039688.2	ENSXETP00000039688.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.50e-40	137.1	33	165

Active Site

Position(s)	Description	Evidence
111	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++k+++el  + p+++ ++++d++dl +++++i+ p++  Y+gg+F +++++ + YP +PPkvk++t ++hPn++ +G+vCl+il+  
   Q: 33   RIQKDINEL--NLPKTCEIEFSDHDDLLNFKLVIC-PDEGFYKGGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILR-- 116
           89******9..8999*******************9.**************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           e+W+p+l+++s+++++q l+ epnpe+pln+eaae l++nr+ ++++v+
   Q: 117  EDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQ 165
           ***********************************************97 PP

Organism

Xenopus tropicalis

Functional Description
(View)

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation (By similarity).

Protein Sequence
(Fasta)

MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCEIE FSDHDDLLNF 60
KLVICPDEGF YKGGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTGTCTCC CCCCGGCCTG TGTGTGGCGA GAGAGAGAAA AGGGACGGAG GGGAGGGAGG 60
CTGGGAGCTT CCCCCAGTGC GGGACATAGG GAGAGCAGGA GGGGGTTGAG GGAGGTGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0019788--F:NEDD8 transferase activity
GO:0018169--F:ribosomal S6-glutamic acid ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0045116--P:protein neddylation

KEGG

xtr:394553

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000196	Aegilops tauschii	56.82	6.00e-55	206.00
IUUC-Aml-002007	Ailuropoda melanoleuca	97.28	1.00e-83	300.00
IUUC-Atr-003170	Amborella trichopoda	60.11	1.00e-65	241.00
IUUC-Aca-005037	Anolis carolinensis	98.91	7.00e-106	375.00
IUUC-Aly-006219	Arabidopsis lyrata	61.08	2.00e-65	241.00
IUUC-Ath-006876	Arabidopsis thaliana	60.33	6.00e-65	239.00
IUUC-Ago-007910	Ashbya gossypii	45.27	3.00e-37	147.00
IUUC-Acl-008364	Aspergillus clavatus	59.87	2.00e-54	204.00
IUUC-Afl-008463	Aspergillus flavus	61.84	5.00e-56	209.00
IUUC-Afu-008803	Aspergillus fumigatus	59.87	2.00e-54	204.00
IUUC-Ani-009422	Aspergillus nidulans	62.50	5.00e-57	213.00
IUUC-Ang-009728	Aspergillus niger	61.76	8.00e-50	188.00
IUUC-Aor-009962	Aspergillus oryzae	61.84	5.00e-56	209.00
IUUC-Ate-010430	Aspergillus terreus	58.39	1.00e-50	192.00
IUUC-Ame-011382	Astyanax mexicanus	91.35	7.00e-98	348.00
IUUC-Bgr-012306	Blumeria graminis	56.52	9.00e-61	225.00
IUUC-Bta-012818	Bos taurus	97.81	2.00e-104	370.00
IUUC-Bci-013626	Botrytis cinerea	57.07	3.00e-61	227.00
IUUC-Bdi-014528	Brachypodium distachyon	62.64	1.00e-62	231.00
IUUC-Bol-016135	Brassica oleracea	60.22	3.00e-65	240.00
IUUC-Bra-017161	Brassica rapa	61.41	1.00e-61	228.00
IUUC-Cja-019213	Callithrix jacchus	95.21	4.00e-102	362.00
IUUC-Cfa-020242	Canis familiaris	96.76	1.00e-102	365.00
IUUC-Cpo-022405	Cavia porcellus	93.44	7.00e-98	348.00
IUUC-Cre-022865	Chlamydomonas reinhardtii	60.57	2.00e-55	207.00
IUUC-Csa-023269	Chlorocebus sabaeus	97.81	2.00e-104	370.00
IUUC-Cin-025333	Ciona intestinalis	75.41	4.00e-82	296.00
IUUC-Csv-025898	Ciona savignyi	62.04	1.00e-74	272.00
IUUC-Cgl-026477	Colletotrichum gloeosporioides	55.74	4.00e-56	210.00
IUUC-Cne-027097	Cryptococcus neoformans	60.99	5.00e-62	229.00
IUUC-Cme-027287	Cyanidioschyzon merolae	50.65	2.00e-20	92.00
IUUC-Dre-028514	Danio rerio	88.11	3.00e-90	323.00
IUUC-Dno-029678	Dasypus novemcinctus	90.16	5.00e-95	339.00
IUUC-Dor-030851	Dipodomys ordii	65.87	4.00e-55	206.00
IUUC-Dse-031265	Dothistroma septosporum	56.83	2.00e-62	231.00
IUUC-Dme-032076	Drosophila melanogaster	74.73	1.00e-79	288.00
IUUC-Ete-032350	Echinops telfairi	72.17	3.00e-43	166.00
IUUC-Eca-034075	Equus caballus	96.72	7.00e-103	365.00
IUUC-Fca-035654	Felis catus	97.28	1.00e-83	300.00
IUUC-Fal-037283	Ficedula albicollis	90.36	1.00e-42	163.00
IUUC-Fox-037877	Fusarium oxysporum	57.84	6.00e-58	216.00
IUUC-Fso-038428	Fusarium solani	57.84	2.00e-63	234.00
IUUC-Gmo-039402	Gadus morhua	90.27	2.00e-97	347.00
IUUC-Ggr-039731	Gaeumannomyces graminis	59.78	2.00e-57	214.00
IUUC-Gga-041122	Gallus gallus	90.96	4.00e-94	337.00
IUUC-Gma-043805	Glycine max	61.08	7.00e-65	239.00
IUUC-Ggo-044436	Gorilla gorilla	97.81	2.00e-104	370.00
IUUC-Hsa-046026	Homo sapiens	97.81	2.00e-104	370.00
IUUC-Hvu-047056	Hordeum vulgare	60.99	7.00e-63	232.00
IUUC-Itr-047889	Ictidomys tridecemlineatus	97.81	2.00e-104	370.00
IUUC-Kpa-049315	Komagataella pastoris	49.72	3.00e-49	187.00
IUUC-Lch-050360	Latimeria chalumnae	76.22	2.00e-59	221.00
IUUC-Lpe-050743	Leersia perrieri	61.02	3.00e-63	234.00
IUUC-Lma-053001	Leptosphaeria maculans	57.92	5.00e-58	216.00
IUUC-Laf-053463	Loxodonta africana	97.28	2.00e-83	300.00
IUUC-Mcc-054966	Macaca mulatta	98.72	2.00e-43	166.00
IUUC-Meu-056085	Macropus eugenii	97.95	6.00e-84	301.00
IUUC-Mor-057250	Magnaporthe oryzae	62.50	6.00e-56	209.00
IUUC-Mpo-057481	Magnaporthe poae	63.82	9.00e-56	209.00
IUUC-Mtr-058251	Medicago truncatula	60.11	1.00e-65	242.00
IUUC-Mla-059119	Melampsora laricipopulina	59.02	6.00e-60	223.00
IUUC-Mga-059881	Meleagris gallopavo	92.45	8.00e-57	211.00
IUUC-Mvi-060449	Microbotryum violaceum	58.66	8.00e-60	222.00
IUUC-Mmr-061511	Microcebus murinus	98.72	2.00e-43	166.00
IUUC-Mmu-063962	Mus musculus	97.81	2.00e-104	370.00
IUUC-Mac-064967	Musa acuminata	62.84	2.00e-68	251.00
IUUC-Mlu-066955	Myotis lucifugus	95.36	3.00e-84	303.00
IUUC-Nfi-068300	Neosartorya fischeri	59.87	2.00e-54	204.00
IUUC-Ncr-068944	Neurospora crassa	57.30	2.00e-57	214.00
IUUC-Nle-069051	Nomascus leucogenys	97.28	1.00e-83	300.00
IUUC-Opr-070635	Ochotona princeps	97.26	6.00e-83	298.00
IUUC-Ont-072348	Oreochromis niloticus	90.27	5.00e-97	346.00
IUUC-Ocu-074905	Oryctolagus cuniculus	97.81	2.00e-104	370.00
IUUC-Oba-075825	Oryza barthii	61.54	3.00e-67	247.00
IUUC-Obr-076067	Oryza brachyantha	60.99	6.00e-67	246.00
IUUC-Ogl-077594	Oryza glaberrima	61.54	3.00e-67	247.00
IUUC-Ogu-078073	Oryza glumaepatula	61.54	3.00e-67	247.00
IUUC-Oin-080060	Oryza indica	61.20	3.00e-64	238.00
IUUC-Olo-080314	Oryza longistaminata	61.54	1.00e-67	248.00
IUUC-Ome-081713	Oryza meridionalis	61.54	2.00e-67	248.00
IUUC-Oni-082426	Oryza nivara	61.54	3.00e-67	247.00
IUUC-Opu-083942	Oryza punctata	61.85	1.00e-63	234.00
IUUC-Oru-085104	Oryza rufipogon	61.54	3.00e-67	247.00
IUUC-Osa-086168	Oryza sativa	61.54	2.00e-67	247.00
IUUC-Olu-087854	Ostreococcus lucimarinus	57.30	1.00e-58	218.00
IUUC-Oga-088580	Otolemur garnettii	97.81	2.00e-104	370.00
IUUC-Oar-089623	Ovis aries	90.54	5.00e-76	275.00
IUUC-Ptr-091161	Pan troglodytes	88.52	5.00e-91	325.00
IUUC-Pan-092119	Papio anubis	97.28	1.00e-83	300.00
IUUC-Psi-093494	Pelodiscus sinensis	98.64	5.00e-85	305.00
IUUC-Pno-094972	Phaeosphaeria nodorum	56.02	6.00e-56	209.00
IUUC-Ppa-095187	Physcomitrella patens	68.31	2.00e-71	261.00
IUUC-Pfo-097205	Poecilia formosa	86.10	5.00e-88	316.00
IUUC-Pab-098434	Pongo abelii	97.81	2.00e-104	370.00
IUUC-Pop-099789	Populus trichocarpa	61.75	6.00e-66	243.00
IUUC-Pca-100300	Procavia capensis	97.26	7.00e-83	298.00
IUUC-Ppe-101143	Prunus persica	60.66	7.00e-66	242.00
IUUC-Pva-102143	Pteropus vampyrus	97.81	2.00e-104	370.00
IUUC-Pgr-103675	Puccinia graminis	59.78	9.00e-59	219.00
IUUC-Ptt-103997	Puccinia triticina	61.24	6.00e-60	223.00
IUUC-Pte-104042	Pyrenophora teres	57.92	1.00e-57	215.00
IUUC-Pyt-104616	Pyrenophora triticirepentis	61.90	9.00e-53	198.00
IUUC-Rno-105107	Rattus norvegicus	97.81	2.00e-104	370.00
IUUC-Sce-106385	Saccharomyces cerevisiae	43.21	2.00e-37	148.00
IUUC-Sha-106899	Sarcophilus harrisii	90.80	1.00e-85	308.00
IUUC-Sja-107789	Schizosaccharomyces japonicus	51.65	7.00e-52	196.00
IUUC-Spo-108143	Schizosaccharomyces pombe	49.73	3.00e-49	187.00
IUUC-Ssl-108427	Sclerotinia sclerotiorum	56.83	6.00e-60	223.00
IUUC-Smo-108673	Selaginella moellendorffii	65.22	7.00e-69	252.00
IUUC-Sit-109702	Setaria italica	64.29	1.00e-62	231.00
IUUC-Sly-111650	Solanum lycopersicum	63.39	2.00e-67	247.00
IUUC-Stu-112655	Solanum tuberosum	62.84	8.00e-68	249.00
IUUC-Sar-113632	Sorex araneus	97.27	2.00e-103	367.00
IUUC-Sbi-114357	Sorghum bicolor	64.84	1.00e-63	234.00
IUUC-Sre-114912	Sporisorium reilianum	63.16	3.00e-57	213.00
IUUC-Tsy-119639	Tarsius syrichta	76.51	7.00e-60	222.00
IUUC-Tni-119674	Tetraodon nigroviridis	77.84	7.00e-78	282.00
IUUC-Tca-121359	Theobroma cacao	62.84	5.00e-67	246.00
IUUC-Tre-122115	Trichoderma reesei	59.75	8.00e-57	212.00
IUUC-Tvi-122656	Trichoderma virens	59.75	5.00e-56	209.00
IUUC-Tae-124489	Triticum aestivum	60.99	7.00e-63	232.00
IUUC-Tur-126125	Triticum urartu	60.99	7.00e-63	233.00
IUUC-Tme-126950	Tuber melanosporum	61.78	6.00e-57	213.00
IUUC-Tbe-127874	Tupaia belangeri	71.58	5.00e-66	243.00
IUUC-Ttr-128213	Tursiops truncatus	96.27	8.00e-89	318.00
IUUC-Uma-129329	Ustilago maydis	62.99	5.00e-57	213.00
IUUC-Vda-129754	Verticillium dahliae	60.51	4.00e-56	210.00
IUUC-Vvi-131182	Vitis vinifera	62.30	5.00e-66	243.00
IUUC-Xma-133558	Xiphophorus maculatus	87.03	1.00e-89	321.00
IUUC-Yli-134467	Yarrowia lipolytica	56.04	4.00e-59	220.00
IUUC-Zma-135527	Zea mays	64.84	4.00e-63	233.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence