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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105462
UUCD1 version UUC-RaN-01009
Ensembl Protein ID ENSRNOP00000033950.2
UniProt Accession Q5U300; UBA1_RAT
Genbank Protein ID EDL97701.1; EDL97702.1; AAH85791.1
Protein Name Ubiquitin-like modifier-activating enzyme 1; Ubiquitin-activating enzyme E1
Genbank Nucleotide ID CH474009; CH474009; BC085791
Gene Name Uba1; Ube1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000019164.7 ENSRNOT00000031115.4 ENSRNOP00000033950.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E1 3.50e-237 787.7 451 931
Active Site
Position(s) Description Evidence
632 Glycyl thioester intermediate {ECO:0000250|UniProtKB:Q02053,
ECO:0000255|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g++ v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 451  YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgegGEVVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQM 539
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v++h++++ +++e+i+   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 540  NPYIQVTSHQNRVGPDTERIYdddFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 628
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++ +++++a++++++
   Q: 629  IPICTLKNFPNAIEHTLQWArdefeglfkqpaENVNQYL-TDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWACHHWHT 716
           ***************************************.77888888999************************************** PP
   S: 248  ttinsikqllksfecdivtkskspfwv..........................................sfcsnaealqvp........ 286
           ++ n+i+qll++f++d++t+s++pfw+                                           + s+ +++qvp        
   Q: 717  QYCNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphpltfdvnntlhldyvmaaanlfaqtygltgsqdraAVASLLQSVQVPeftpksgv 805
           ******************************************************************99977777777777755555555 PP
   S: 287  ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipa 368
           + +++d+e ++a+a+     l+ l+++l + +k +g k++ ++fekddds  ++d++ aa+nlrae+++i+p +d+++ k iag+iipa
   Q: 806  KIHVSDQELQSANASvddsrLEELKATLPSPDKLPGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYDISP-ADRHKSKLIAGKIIPA 893
           66666666666666688889****************************************************.**************** PP
   S: 369  iattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iatt+a+v Gl+++E++Kvv+g  + + +kn fl++a+
   Q: 894  IATTTAAVVGLVCLELYKVVQGhqQLDSYKNGFLNLAL 931
           **********************9999********9875 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
 Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
Protein Sequence
(Fasta)
MSSSPLSKKR RVSGPDPKPG SNCSSAQSVL SEVSSVPTNG MAKNGSEADI DESLYSRQLY 60
VLGHEAMKML QTSSVLVSGL RGLGVEIAKN IILGGVKAVT LHDQGTTQWA DLSSQFYLRE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105462|E1,E1_ThiF|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGGTTTTG TTCCGGCCTT GGGCTCTGCC GCCGCCATCT TGTGTCGGCT GCTGGGGTGA 60
AGGAGGGTGT CAAGGAAGAC CACAACCACC GCGGTCGGGG GAGGAGAAGG CGACAGTGAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105462|E1,E1_ThiF|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0436--Ligase
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus
KEGG rno:314432
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000367 Aegilops tauschii 45.86 0.00e+00 852.00
IUUC-Aml-001311 Ailuropoda melanoleuca 94.82 0.00e+00 2058.00
IUUC-Atr-002684 Amborella trichopoda 45.10 0.00e+00 885.00
IUUC-Aca-004620 Anolis carolinensis 80.33 0.00e+00 1786.00
IUUC-Aly-005515 Arabidopsis lyrata 45.64 0.00e+00 909.00
IUUC-Ath-006891 Arabidopsis thaliana 46.03 0.00e+00 915.00
IUUC-Ago-007873 Ashbya gossypii 54.29 0.00e+00 1065.00
IUUC-Acl-008181 Aspergillus clavatus 53.52 0.00e+00 1059.00
IUUC-Afl-008455 Aspergillus flavus 53.35 0.00e+00 1023.00
IUUC-Afu-009065 Aspergillus fumigatus 53.18 0.00e+00 1080.00
IUUC-Ani-009371 Aspergillus nidulans 53.19 0.00e+00 1050.00
IUUC-Ang-009737 Aspergillus niger 53.55 0.00e+00 1068.00
IUUC-Aor-010007 Aspergillus oryzae 53.35 0.00e+00 1025.00
IUUC-Ate-010466 Aspergillus terreus 53.30 0.00e+00 1091.00
IUUC-Ame-010933 Astyanax mexicanus 78.66 0.00e+00 1688.00
IUUC-Bgr-012281 Blumeria graminis 53.53 0.00e+00 1084.00
IUUC-Bta-012767 Bos taurus 95.46 0.00e+00 2078.00
IUUC-Bci-013721 Botrytis cinerea 54.02 0.00e+00 1027.00
IUUC-Bdi-014843 Brachypodium distachyon 45.27 0.00e+00 866.00
IUUC-Bol-015665 Brassica oleracea 44.20 0.00e+00 900.00
IUUC-Bra-017252 Brassica rapa 44.23 0.00e+00 900.00
IUUC-Cel-018260 Caenorhabditis elegans 49.18 0.00e+00 956.00
IUUC-Cja-019152 Callithrix jacchus 96.41 0.00e+00 2094.00
IUUC-Cfa-020622 Canis familiaris 93.76 0.00e+00 1990.00
IUUC-Cpo-022526 Cavia porcellus 95.84 0.00e+00 2062.00
IUUC-Cre-022702 Chlamydomonas reinhardtii 45.18 0.00e+00 840.00
IUUC-Csa-023780 Chlorocebus sabaeus 96.22 0.00e+00 2091.00
IUUC-Cho-024896 Choloepus hoffmanni 84.94 9.00e-116 411.00
IUUC-Cin-025790 Ciona intestinalis 62.98 0.00e+00 1357.00
IUUC-Csv-026084 Ciona savignyi 60.32 0.00e+00 1348.00
IUUC-Cgl-026512 Colletotrichum gloeosporioides 54.22 0.00e+00 1107.00
IUUC-Cne-026960 Cryptococcus neoformans 55.63 0.00e+00 1122.00
IUUC-Cme-027290 Cyanidioschyzon merolae 44.22 0.00e+00 835.00
IUUC-Dre-028149 Danio rerio 78.75 0.00e+00 1720.00
IUUC-Dno-028884 Dasypus novemcinctus 95.18 0.00e+00 2076.00
IUUC-Dor-030229 Dipodomys ordii 91.30 0.00e+00 1970.00
IUUC-Dse-031524 Dothistroma septosporum 51.81 0.00e+00 1069.00
IUUC-Dme-032045 Drosophila melanogaster 60.33 0.00e+00 1274.00
IUUC-Ete-032544 Echinops telfairi 83.43 0.00e+00 865.00
IUUC-Eca-033330 Equus caballus 96.31 0.00e+00 2094.00
IUUC-Fca-036255 Felis catus 96.31 0.00e+00 2068.00
IUUC-Fal-037445 Ficedula albicollis 49.04 0.00e+00 893.00
IUUC-Fox-038007 Fusarium oxysporum 53.50 1.00e-166 580.00
IUUC-Fso-038339 Fusarium solani 54.05 0.00e+00 1068.00
IUUC-Gmo-039338 Gadus morhua 75.43 0.00e+00 1613.00
IUUC-Ggr-039823 Gaeumannomyces graminis 54.24 0.00e+00 1124.00
IUUC-Gga-040365 Gallus gallus 47.51 0.00e+00 820.00
IUUC-Gac-041773 Gasterosteus aculeatus 75.43 0.00e+00 1614.00
IUUC-Gma-043198 Glycine max 44.23 0.00e+00 878.00
IUUC-Ggo-045336 Gorilla gorilla 96.60 0.00e+00 2074.00
IUUC-Hsa-045982 Homo sapiens 96.41 0.00e+00 2069.00
IUUC-Hvu-047418 Hordeum vulgare 45.49 0.00e+00 872.00
IUUC-Itr-048460 Ictidomys tridecemlineatus 96.41 0.00e+00 2099.00
IUUC-Kpa-049112 Komagataella pastoris 51.43 0.00e+00 1016.00
IUUC-Lch-050371 Latimeria chalumnae 79.98 0.00e+00 1779.00
IUUC-Lpe-051299 Leersia perrieri 44.08 0.00e+00 879.00
IUUC-Loc-052936 Lepisosteus oculatus 80.26 0.00e+00 1757.00
IUUC-Lma-053315 Leptosphaeria maculans 52.91 0.00e+00 1095.00
IUUC-Laf-053948 Loxodonta africana 93.29 0.00e+00 2024.00
IUUC-Mcc-055843 Macaca mulatta 96.50 0.00e+00 2101.00
IUUC-Meu-056258 Macropus eugenii 87.15 0.00e+00 1909.00
IUUC-Mor-057269 Magnaporthe oryzae 54.29 0.00e+00 1099.00
IUUC-Mpo-057435 Magnaporthe poae 54.39 0.00e+00 1092.00
IUUC-Mtr-058572 Medicago truncatula 44.18 0.00e+00 856.00
IUUC-Mla-059176 Melampsora laricipopulina 56.04 0.00e+00 1104.00
IUUC-Mvi-060437 Microbotryum violaceum 53.68 0.00e+00 1075.00
IUUC-Mmr-061405 Microcebus murinus 94.23 0.00e+00 2032.00
IUUC-Mdo-062032 Monodelphis domestica 85.38 0.00e+00 1878.00
IUUC-Mmu-063280 Mus musculus 98.20 0.00e+00 2122.00
IUUC-Mac-065505 Musa acuminata 44.91 0.00e+00 880.00
IUUC-Mpu-066409 Mustela putorius furo 96.22 0.00e+00 2095.00
IUUC-Mlu-067217 Myotis lucifugus 93.95 0.00e+00 2047.00
IUUC-Nfi-068407 Neosartorya fischeri 53.47 0.00e+00 1060.00
IUUC-Ncr-068698 Neurospora crassa 55.06 0.00e+00 1113.00
IUUC-Nle-070072 Nomascus leucogenys 91.52 0.00e+00 1947.00
IUUC-Ont-071671 Oreochromis niloticus 77.92 0.00e+00 1688.00
IUUC-Oan-073306 Ornithorhynchus anatinus 48.99 0.00e+00 723.00
IUUC-Ocu-074544 Oryctolagus cuniculus 95.37 0.00e+00 2081.00
IUUC-Oba-075120 Oryza barthii 45.14 0.00e+00 874.00
IUUC-Obr-076557 Oryza brachyantha 45.71 0.00e+00 865.00
IUUC-Ogl-077887 Oryza glaberrima 45.14 0.00e+00 875.00
IUUC-Ogu-078305 Oryza glumaepatula 43.85 0.00e+00 874.00
IUUC-Oin-080154 Oryza indica 43.85 0.00e+00 874.00
IUUC-Olo-081089 Oryza longistaminata 43.94 0.00e+00 874.00
IUUC-Ome-081942 Oryza meridionalis 45.24 0.00e+00 875.00
IUUC-Oni-082365 Oryza nivara 45.14 0.00e+00 876.00
IUUC-Opu-083977 Oryza punctata 45.41 0.00e+00 877.00
IUUC-Oru-084469 Oryza rufipogon 43.94 0.00e+00 877.00
IUUC-Osa-085949 Oryza sativa 45.34 0.00e+00 883.00
IUUC-Ola-087002 Oryzias latipes 77.44 0.00e+00 1683.00
IUUC-Olu-087687 Ostreococcus lucimarinus 44.21 0.00e+00 820.00
IUUC-Oga-088594 Otolemur garnettii 95.85 0.00e+00 2056.00
IUUC-Oar-090068 Ovis aries 95.66 0.00e+00 2081.00
IUUC-Pan-092114 Papio anubis 96.60 0.00e+00 2101.00
IUUC-Pma-094214 Petromyzon marinus 58.72 4.00e-53 200.00
IUUC-Pno-095154 Phaeosphaeria nodorum 53.25 0.00e+00 1104.00
IUUC-Ppa-095416 Physcomitrella patens 45.38 0.00e+00 897.00
IUUC-Pfo-097184 Poecilia formosa 77.63 0.00e+00 1684.00
IUUC-Pab-097861 Pongo abelii 96.22 0.00e+00 2055.00
IUUC-Pop-098934 Populus trichocarpa 44.69 0.00e+00 914.00
IUUC-Pca-100347 Procavia capensis 89.98 0.00e+00 1628.00
IUUC-Ppe-102012 Prunus persica 44.05 0.00e+00 894.00
IUUC-Pva-102584 Pteropus vampyrus 96.12 0.00e+00 2105.00
IUUC-Pgr-103336 Puccinia graminis 54.26 0.00e+00 1057.00
IUUC-Ptt-103939 Puccinia triticina 53.60 0.00e+00 1063.00
IUUC-Pte-104200 Pyrenophora teres 53.16 0.00e+00 1092.00
IUUC-Pyt-104441 Pyrenophora triticirepentis 52.06 0.00e+00 1082.00
IUUC-Sce-106245 Saccharomyces cerevisiae 52.31 0.00e+00 1085.00
IUUC-Sha-107142 Sarcophilus harrisii 86.86 0.00e+00 1918.00
IUUC-Sja-107841 Schizosaccharomyces japonicus 55.41 0.00e+00 1136.00
IUUC-Spo-108034 Schizosaccharomyces pombe 53.56 0.00e+00 1075.00
IUUC-Ssl-108497 Sclerotinia sclerotiorum 54.20 0.00e+00 1053.00
IUUC-Smo-109211 Selaginella moellendorffii 45.92 0.00e+00 886.00
IUUC-Sit-110281 Setaria italica 45.45 0.00e+00 893.00
IUUC-Sly-110914 Solanum lycopersicum 44.21 0.00e+00 895.00
IUUC-Stu-112109 Solanum tuberosum 44.40 0.00e+00 905.00
IUUC-Sar-113737 Sorex araneus 94.61 0.00e+00 2056.00
IUUC-Sbi-114089 Sorghum bicolor 45.34 0.00e+00 890.00
IUUC-Sre-115148 Sporisorium reilianum 54.59 0.00e+00 1088.00
IUUC-Ssc-115777 Sus scrofa 96.22 0.00e+00 2088.00
IUUC-Tru-118742 Takifugu rubripes 77.06 0.00e+00 1627.00
IUUC-Tni-120401 Tetraodon nigroviridis 77.25 0.00e+00 1627.00
IUUC-Tca-121672 Theobroma cacao 44.22 0.00e+00 896.00
IUUC-Tre-122009 Trichoderma reesei 53.68 0.00e+00 1051.00
IUUC-Tvi-122259 Trichoderma virens 53.92 0.00e+00 1038.00
IUUC-Tae-125113 Triticum aestivum 45.86 0.00e+00 852.00
IUUC-Tur-126189 Triticum urartu 45.66 0.00e+00 853.00
IUUC-Tme-127055 Tuber melanosporum 52.88 0.00e+00 1008.00
IUUC-Tbe-127487 Tupaia belangeri 95.71 0.00e+00 1041.00
IUUC-Ttr-128331 Tursiops truncatus 95.18 0.00e+00 2056.00
IUUC-Uma-129387 Ustilago maydis 54.67 0.00e+00 1082.00
IUUC-Vda-129977 Verticillium dahliae 53.47 0.00e+00 1013.00
IUUC-Vvi-130857 Vitis vinifera 45.03 0.00e+00 900.00
IUUC-Xtr-132026 Xenopus tropicalis 64.26 0.00e+00 1281.00
IUUC-Xma-133805 Xiphophorus maculatus 76.86 0.00e+00 1653.00
IUUC-Yli-134547 Yarrowia lipolytica 54.45 0.00e+00 1115.00
IUUC-Zma-135052 Zea mays 45.49 0.00e+00 895.00
Created Date 25-Jun-2017

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