iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000021218.7	ENSRNOT00000083769.1	ENSRNOP00000068665.1
ENSRNOG00000021218.7	ENSRNOT00000028814.5	ENSRNOP00000028814.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	96.66	0.00e+00	1100.00	IUUC-Hsa-045973

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1. Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).

Protein Sequence
(Fasta)

MAELGELKHM VMSFRVSELQ VLLGFAGRNK SGRKHELLAK ALHLLKSSCA PSVQMKIKEL 60
YRRRFPRKTL GPSDLSLLSL PPGTSPVGSP SPLASIPPTL LTPGTLLGPK REVDMHPPLP 120

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Nucleotide Sequence
(Fasta)

TGCGCCGGTC CCTGGGCCTG AGCTCCGGCT CGGGCTGGGG CGCCTGCGAT GTCTCAAGAT 60
GGCGGAGCTG GGCGAATTAA AGGTACCGGC CCCCTCCCCC AGCCCCAGCA GGACTCGCTC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027226--PIAS3
IPR023321--PINIT
IPR003034--SAP_dom
IPR004181--Znf_MIZ

PROSITE

PS51466--PINIT
PS50800--SAP
PS51044--ZF_SP_RING

Pfam

PF14324--PINIT
PF02891--zf-MIZ

SMART

SM00513--SAP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0045202--C:synapse
GO:0016874--F:ligase activity
GO:0015459--F:potassium channel regulator activity
GO:0008022--F:protein C-terminus binding
GO:0047485--F:protein N-terminus binding
GO:0019789--F:SUMO transferase activity
GO:0008270--F:zinc ion binding
GO:0033234--P:negative regulation of protein sumoylation
GO:0010628--P:positive regulation of gene expression
GO:0045838--P:positive regulation of membrane potential
GO:0033235--P:positive regulation of protein sumoylation
GO:0016925--P:protein sumoylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009725--P:response to hormone
GO:0006351--P:transcription, DNA-templated

KEGG

rno:83614

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002142	Ailuropoda melanoleuca	95.13	0.00e+00	1095.00
IUUC-Aca-004903	Anolis carolinensis	69.86	0.00e+00	828.00
IUUC-Ago-007762	Ashbya gossypii	26.92	3.00e-18	87.40
IUUC-Acl-008204	Aspergillus clavatus	29.86	2.00e-26	113.00
IUUC-Afl-008672	Aspergillus flavus	30.07	4.00e-27	116.00
IUUC-Afu-008758	Aspergillus fumigatus	30.07	2.00e-28	120.00
IUUC-Ani-009389	Aspergillus nidulans	32.05	8.00e-25	108.00
IUUC-Ang-009590	Aspergillus niger	31.54	1.00e-27	117.00
IUUC-Aor-009912	Aspergillus oryzae	37.59	9.00e-23	101.00
IUUC-Ate-010496	Aspergillus terreus	35.44	9.00e-28	118.00
IUUC-Bta-013566	Bos taurus	96.50	0.00e+00	1103.00
IUUC-Bol-015575	Brassica oleracea	24.63	1.00e-17	85.10
IUUC-Cja-019111	Callithrix jacchus	95.87	0.00e+00	1090.00
IUUC-Cfa-020209	Canis familiaris	95.70	0.00e+00	1114.00
IUUC-Cpo-022188	Cavia porcellus	95.06	0.00e+00	1122.00
IUUC-Csa-024163	Chlorocebus sabaeus	97.23	0.00e+00	961.00
IUUC-Cho-024816	Choloepus hoffmanni	56.31	3.00e-131	462.00
IUUC-Cin-025791	Ciona intestinalis	44.44	2.00e-92	333.00
IUUC-Dno-029139	Dasypus novemcinctus	96.13	0.00e+00	1048.00
IUUC-Dor-030842	Dipodomys ordii	92.58	0.00e+00	1061.00
IUUC-Eca-034115	Equus caballus	96.34	0.00e+00	1095.00
IUUC-Eeu-034486	Erinaceus europaeus	91.36	0.00e+00	734.00
IUUC-Fca-035527	Felis catus	92.17	0.00e+00	1106.00
IUUC-Ggo-045185	Gorilla gorilla	96.97	0.00e+00	1102.00
IUUC-Hsa-045973	Homo sapiens	96.66	0.00e+00	1095.00
IUUC-Itr-049072	Ictidomys tridecemlineatus	95.27	0.00e+00	1087.00
IUUC-Kpa-049203	Komagataella pastoris	30.36	4.00e-22	100.00
IUUC-Lch-050349	Latimeria chalumnae	69.38	0.00e+00	825.00
IUUC-Lma-053196	Leptosphaeria maculans	27.74	2.00e-29	123.00
IUUC-Laf-054406	Loxodonta africana	95.06	0.00e+00	1113.00
IUUC-Mcc-054886	Macaca mulatta	96.66	0.00e+00	1098.00
IUUC-Meu-055949	Macropus eugenii	85.06	0.00e+00	939.00
IUUC-Mmr-060659	Microcebus murinus	96.82	0.00e+00	1104.00
IUUC-Mdo-062925	Monodelphis domestica	85.30	0.00e+00	956.00
IUUC-Mmu-064247	Mus musculus	98.25	0.00e+00	1110.00
IUUC-Mpu-066833	Mustela putorius furo	95.24	0.00e+00	1080.00
IUUC-Mlu-067384	Myotis lucifugus	93.25	0.00e+00	1015.00
IUUC-Nfi-068586	Neosartorya fischeri	30.07	2.00e-28	120.00
IUUC-Ocu-074264	Oryctolagus cuniculus	96.89	0.00e+00	844.00
IUUC-Oga-088281	Otolemur garnettii	95.81	0.00e+00	1086.00
IUUC-Oar-090090	Ovis aries	96.01	0.00e+00	1094.00
IUUC-Ptr-090687	Pan troglodytes	89.97	0.00e+00	983.00
IUUC-Pan-091813	Papio anubis	96.82	0.00e+00	1100.00
IUUC-Psi-092943	Pelodiscus sinensis	76.60	0.00e+00	873.00
IUUC-Pab-097650	Pongo abelii	97.09	0.00e+00	1086.00
IUUC-Pop-099241	Populus trichocarpa	26.79	7.00e-12	66.20
IUUC-Pca-100372	Procavia capensis	93.06	0.00e+00	934.00
IUUC-Pva-103134	Pteropus vampyrus	95.98	0.00e+00	992.00
IUUC-Pte-104331	Pyrenophora teres	29.41	4.00e-30	125.00
IUUC-Pyt-104673	Pyrenophora triticirepentis	29.93	3.00e-28	119.00
IUUC-Sha-107250	Sarcophilus harrisii	85.17	0.00e+00	987.00
IUUC-Ssc-115626	Sus scrofa	96.50	0.00e+00	1105.00
IUUC-Tvi-122408	Trichoderma virens	31.66	1.00e-29	124.00
IUUC-Tbe-127583	Tupaia belangeri	96.05	0.00e+00	771.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence