iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132170.19	ENST00000397026.6	ENSP00000380221.2
ENSG00000132170.19	ENST00000397000.5	ENSP00000380196.1
ENSG00000132170.19	ENST00000287820.10	ENSP00000287820.6
ENSG00000132170.19	ENST00000397023.5	ENSP00000380218.1
ENSG00000132170.19	ENST00000396999.2	ENSP00000380195.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	JASPAR	circBase
circRNADb	CircNet	miRTarBase	microRNA
TRANSFAC	miRWalk	TargetScan	miRecords
RepTar	miRNAMap	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC	PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	23250430; 24292674

Organism

Homo sapiens

Functional Description
(View)

(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.

Protein Sequence
(Fasta)

MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 60
DIKPFTTVDF SSISTPHYED IPFTRTDPVV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTTACAAA CGCAAGGAAC TCTGAAAGTG TGCAGCACCA CCGATCAGAA GAGAAAACCA 60
AGGGACCCGA AATATGCTTT AATTAAATTT TCTTTTAAAA TGTCACTGGA AAGAACATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0219--Diabetes mellitus
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0550--Obesity
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003077--1Cnucl_rcpt_G
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR022590--PPARgamma_N
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF12577--PPARgamma_N
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01291--PROXISOMPAGR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0090575--C:RNA polymerase II transcription factor complex
GO:0033613--F:activating transcription factor binding
GO:0051393--F:alpha-actinin binding
GO:0050544--F:arachidonic acid binding
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0019899--F:enzyme binding
GO:0042802--F:identical protein binding
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004955--F:prostaglandin receptor activity
GO:0046965--F:retinoid X receptor binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0031100--P:animal organ regeneration
GO:0045165--P:cell fate commitment
GO:0048469--P:cell maturation
GO:0071455--P:cellular response to hyperoxia
GO:0032869--P:cellular response to insulin stimulus
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071306--P:cellular response to vitamin E
GO:0030855--P:epithelial cell differentiation
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0007507--P:heart development
GO:0045087--P:innate immune response
GO:0055088--P:lipid homeostasis
GO:0006629--P:lipid metabolic process
GO:0042953--P:lipoprotein transport
GO:0015909--P:long-chain fatty acid transport
GO:0045713--P:low-density lipoprotein particle receptor biosynthetic process
GO:0010742--P:macrophage derived foam cell differentiation
GO:0030224--P:monocyte differentiation
GO:0002674--P:negative regulation of acute inflammatory response
GO:0030308--P:negative regulation of cell growth
GO:0010887--P:negative regulation of cholesterol storage
GO:0032966--P:negative regulation of collagen biosynthetic process
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:2000230--P:negative regulation of pancreatic stellate cell proliferation
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0051974--P:negative regulation of telomerase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0035357--P:peroxisome proliferator activated receptor signaling pathway
GO:0001890--P:placenta development
GO:0045600--P:positive regulation of fat cell differentiation
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0048714--P:positive regulation of oligodendrocyte differentiation
GO:0060100--P:positive regulation of phagocytosis, engulfment
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0008217--P:regulation of blood pressure
GO:0060694--P:regulation of cholesterol transporter activity
GO:0042752--P:regulation of circadian rhythm
GO:0060850--P:regulation of transcription involved in cell fate commitment
GO:0031000--P:response to caffeine
GO:0009409--P:response to cold
GO:0042493--P:response to drug
GO:0043627--P:response to estrogen
GO:0035902--P:response to immobilization stress
GO:0033993--P:response to lipid
GO:0055098--P:response to low-density lipoprotein particle
GO:0009612--P:response to mechanical stimulus
GO:1901558--P:response to metformin
GO:0007584--P:response to nutrient
GO:0032526--P:response to retinoic acid
GO:0042594--P:response to starvation
GO:0033189--P:response to vitamin A
GO:0048511--P:rhythmic process
GO:0007165--P:signal transduction
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0050872--P:white fat cell differentiation

KEGG

hsa:5468

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001214	Ailuropoda melanoleuca	95.25	0.00e+00	962.00
IUUC-Aca-005129	Anolis carolinensis	88.75	0.00e+00	876.00
IUUC-Ame-010818	Astyanax mexicanus	65.78	0.00e+00	644.00
IUUC-Bta-013226	Bos taurus	95.84	0.00e+00	977.00
IUUC-Cja-019236	Callithrix jacchus	99.01	0.00e+00	1008.00
IUUC-Cfa-020281	Canis familiaris	98.22	0.00e+00	1001.00
IUUC-Cpo-021587	Cavia porcellus	96.23	0.00e+00	930.00
IUUC-Csa-023400	Chlorocebus sabaeus	99.16	0.00e+00	951.00
IUUC-Cho-024593	Choloepus hoffmanni	85.94	0.00e+00	851.00
IUUC-Dre-028176	Danio rerio	61.28	1.00e-154	539.00
IUUC-Dno-029063	Dasypus novemcinctus	93.47	0.00e+00	945.00
IUUC-Ete-032520	Echinops telfairi	94.26	0.00e+00	949.00
IUUC-Fca-035935	Felis catus	97.82	0.00e+00	997.00
IUUC-Fal-037524	Ficedula albicollis	92.21	0.00e+00	883.00
IUUC-Gga-041223	Gallus gallus	92.84	0.00e+00	888.00
IUUC-Gac-042156	Gasterosteus aculeatus	62.45	0.00e+00	638.00
IUUC-Ggo-045265	Gorilla gorilla	99.60	0.00e+00	1015.00
IUUC-Lch-049759	Latimeria chalumnae	80.56	0.00e+00	680.00
IUUC-Loc-051870	Lepisosteus oculatus	74.17	0.00e+00	748.00
IUUC-Laf-054483	Loxodonta africana	96.04	0.00e+00	974.00
IUUC-Meu-056587	Macropus eugenii	94.60	0.00e+00	921.00
IUUC-Mga-059530	Meleagris gallopavo	92.84	0.00e+00	888.00
IUUC-Mmr-060576	Microcebus murinus	96.24	0.00e+00	984.00
IUUC-Mdo-061854	Monodelphis domestica	98.11	0.00e+00	937.00
IUUC-Mmu-063724	Mus musculus	96.24	0.00e+00	986.00
IUUC-Mpu-066888	Mustela putorius furo	98.74	0.00e+00	980.00
IUUC-Mlu-067978	Myotis lucifugus	97.03	0.00e+00	1022.00
IUUC-Nle-070069	Nomascus leucogenys	99.60	0.00e+00	1014.00
IUUC-Opr-070630	Ochotona princeps	93.85	0.00e+00	797.00
IUUC-Ont-071399	Oreochromis niloticus	60.41	5.00e-180	624.00
IUUC-Ocu-074862	Oryctolagus cuniculus	97.27	0.00e+00	939.00
IUUC-Ola-087266	Oryzias latipes	56.42	2.00e-159	555.00
IUUC-Oga-089143	Otolemur garnettii	96.63	0.00e+00	991.00
IUUC-Oar-089725	Ovis aries	95.64	0.00e+00	974.00
IUUC-Ptr-091580	Pan troglodytes	99.80	0.00e+00	1016.00
IUUC-Psi-093041	Pelodiscus sinensis	91.40	0.00e+00	872.00
IUUC-Pfo-097438	Poecilia formosa	58.74	2.00e-177	615.00
IUUC-Pab-098333	Pongo abelii	98.74	0.00e+00	944.00
IUUC-Pca-100861	Procavia capensis	97.48	0.00e+00	937.00
IUUC-Pva-102186	Pteropus vampyrus	87.52	0.00e+00	869.00
IUUC-Rno-105583	Rattus norvegicus	95.84	0.00e+00	982.00
IUUC-Sha-107484	Sarcophilus harrisii	96.12	0.00e+00	942.00
IUUC-Sar-112996	Sorex araneus	85.54	0.00e+00	650.00
IUUC-Ssc-115945	Sus scrofa	97.82	0.00e+00	991.00
IUUC-Tsy-119098	Tarsius syrichta	88.71	0.00e+00	874.00
IUUC-Tni-120902	Tetraodon nigroviridis	61.30	2.00e-173	602.00
IUUC-Tbe-127225	Tupaia belangeri	75.64	0.00e+00	715.00
IUUC-Ttr-129292	Tursiops truncatus	97.62	0.00e+00	993.00
IUUC-Vpa-130378	Vicugna pacos	91.10	0.00e+00	786.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence