iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132481.6	ENST00000254816.5	ENSP00000254816.1
ENSG00000132481.6	ENST00000585333.1	ENSP00000467645.1
ENSG00000132481.6	ENST00000587339.2	ENSP00000465010.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	3.50e-05	25.4	7	76
E3 activity/RING/RING	3.70e-10	41.8	9	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIek.wlasggk.........tcPvtrqpl.teedlvPnltlrrl 64
           f CpI le+ r+Pv+lp+G+ +  +++   w  +g +          cP++++p+ +  +l  n+tl +l
   Q: 7    FSCPICLEPLREPVTLPCGHNFCLACLGAlWPHRGASgaggpggaaRCPLCQEPFpDGLQLRKNHTLSEL 76
           99***********************997624444444667999999*********7778899**999776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw....pglknssskefrCPlCr 46
           C+iCle++++ p++lpCgH f++ Cl   w            +++rCPlC+
   Q: 9    CPICLEPLRE-PVTLPCGHNFCLACLgALWphrgASGAGGPGGAARCPLCQ 58
           ********99.***************7777777744444457788*****7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDGSGPFSCP ICLEPLREPV TLPCGHNFCL ACLGALWPHR GASGAGGPGG AARCPLCQEP 60
FPDGLQLRKN HTLSELLQLR QGSGPGSGPG PAPALAPEPS APSALPSVPE PSAPCAPEPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGCCC TGGGCGGCCG CGGAGTCATG GACGGCAGTG GACCCTTCAG CTGCCCCATC 60
TGCCTAGAGC CACTCCGGGA GCCGGTGACG CTGCCCTGCG GCCACAACTT CTGTCTCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding

KEGG

hsa:91107

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001364	Ailuropoda melanoleuca	89.46	0.00e+00	756.00
IUUC-Aca-005308	Anolis carolinensis	54.23	4.00e-106	377.00
IUUC-Bta-013256	Bos taurus	88.00	0.00e+00	855.00
IUUC-Cja-018778	Callithrix jacchus	87.99	0.00e+00	894.00
IUUC-Cfa-020705	Canis familiaris	90.53	5.00e-98	352.00
IUUC-Cpo-021797	Cavia porcellus	84.11	0.00e+00	892.00
IUUC-Csa-023409	Chlorocebus sabaeus	93.91	0.00e+00	955.00
IUUC-Dor-030726	Dipodomys ordii	86.14	0.00e+00	947.00
IUUC-Eca-033641	Equus caballus	90.58	3.00e-180	624.00
IUUC-Eeu-034657	Erinaceus europaeus	90.57	6.00e-107	380.00
IUUC-Fca-036282	Felis catus	76.79	4.00e-179	621.00
IUUC-Fal-036823	Ficedula albicollis	55.96	5.00e-121	427.00
IUUC-Gga-040334	Gallus gallus	54.92	8.00e-118	416.00
IUUC-Ggo-044515	Gorilla gorilla	97.81	0.00e+00	996.00
IUUC-Itr-048949	Ictidomys tridecemlineatus	77.12	0.00e+00	804.00
IUUC-Laf-054448	Loxodonta africana	86.52	0.00e+00	940.00
IUUC-Mcc-054916	Macaca mulatta	94.06	0.00e+00	957.00
IUUC-Meu-056438	Macropus eugenii	79.15	0.00e+00	939.00
IUUC-Mga-059813	Meleagris gallopavo	54.81	4.00e-138	484.00
IUUC-Mmr-060614	Microcebus murinus	85.00	0.00e+00	878.00
IUUC-Mdo-062464	Monodelphis domestica	77.98	0.00e+00	850.00
IUUC-Mmu-063631	Mus musculus	88.01	0.00e+00	943.00
IUUC-Mpu-066154	Mustela putorius furo	90.50	0.00e+00	627.00
IUUC-Mlu-067203	Myotis lucifugus	89.29	0.00e+00	693.00
IUUC-Nle-069591	Nomascus leucogenys	96.86	0.00e+00	729.00
IUUC-Opr-070649	Ochotona princeps	91.21	0.00e+00	781.00
IUUC-Oan-073653	Ornithorhynchus anatinus	84.91	6.00e-104	371.00
IUUC-Ocu-074752	Oryctolagus cuniculus	88.85	0.00e+00	866.00
IUUC-Oga-088971	Otolemur garnettii	90.91	0.00e+00	968.00
IUUC-Oar-089868	Ovis aries	76.50	2.00e-142	498.00
IUUC-Ptr-091634	Pan troglodytes	96.57	0.00e+00	997.00
IUUC-Pan-092126	Papio anubis	92.32	0.00e+00	951.00
IUUC-Psi-093955	Pelodiscus sinensis	58.60	1.00e-114	405.00
IUUC-Pfo-096134	Poecilia formosa	29.57	2.00e-52	200.00
IUUC-Pab-097985	Pongo abelii	94.06	0.00e+00	961.00
IUUC-Pva-102360	Pteropus vampyrus	81.09	0.00e+00	808.00
IUUC-Rno-104845	Rattus norvegicus	87.07	0.00e+00	910.00
IUUC-Sha-107613	Sarcophilus harrisii	79.90	5.00e-172	597.00
IUUC-Ssc-116292	Sus scrofa	89.81	0.00e+00	808.00
IUUC-Tgu-116986	Taeniopygia guttata	52.05	1.00e-165	577.00
IUUC-Tbe-127869	Tupaia belangeri	77.24	5.00e-163	567.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence