iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20553626

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	9.20e-08	34.2	93	134

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+Cledf  kd++ vlpC+H+fh++Cl kw         +  CP C+
   Q: 93   CAVCLEDFkgKDELGVLPCQHAFHRKCLVKW------LEVRCVCPMCN 134
           ********99778******************......999999****7 PP

Organism

Homo sapiens

Functional Description
(View)

May induce necrosis and apoptosis. May play a role in cell viability.

Protein Sequence
(Fasta)

MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM LSLIFCCYFI 60
SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF KGKDELGVLP CQHAFHRKCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTTCGGAA CCCCAGCCAG CTCACCTCTG CGCCGCTGAA CCCGATCCGA GCCTCCGGCA 60
AAGGTTTTTC CCTCCTCCCC CGGCCGAGGG CTTCTGCAGC CCGGGCACCC CCGCCCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:79845

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002066	Ailuropoda melanoleuca	98.06	4.00e-88	316.00
IUUC-Apl-003691	Anas platyrhynchos	83.46	7.00e-65	238.00
IUUC-Aca-004989	Anolis carolinensis	88.39	1.00e-81	294.00
IUUC-Ame-011731	Astyanax mexicanus	81.94	1.00e-76	278.00
IUUC-Bta-012760	Bos taurus	96.60	6.00e-80	289.00
IUUC-Cja-019442	Callithrix jacchus	98.71	9.00e-89	318.00
IUUC-Cfa-021257	Canis familiaris	94.19	8.00e-83	298.00
IUUC-Cpo-021821	Cavia porcellus	90.51	4.00e-81	293.00
IUUC-Csa-023926	Chlorocebus sabaeus	98.71	1.00e-88	318.00
IUUC-Cho-024763	Choloepus hoffmanni	95.74	2.00e-50	189.00
IUUC-Cme-027308	Cyanidioschyzon merolae	36.00	5.00e-09	56.60
IUUC-Dre-028547	Danio rerio	82.58	7.00e-77	278.00
IUUC-Dno-029352	Dasypus novemcinctus	98.06	5.00e-88	316.00
IUUC-Dor-030113	Dipodomys ordii	96.81	1.00e-50	190.00
IUUC-Ete-032590	Echinops telfairi	83.23	1.00e-73	268.00
IUUC-Eca-033808	Equus caballus	97.42	8.00e-88	315.00
IUUC-Eeu-035101	Erinaceus europaeus	96.58	5.00e-80	289.00
IUUC-Fca-035925	Felis catus	98.71	2.00e-88	317.00
IUUC-Gmo-038545	Gadus morhua	87.74	3.00e-79	286.00
IUUC-Gga-041003	Gallus gallus	80.65	3.00e-73	266.00
IUUC-Gac-042633	Gasterosteus aculeatus	62.04	3.00e-41	160.00
IUUC-Itr-048723	Ictidomys tridecemlineatus	96.13	9.00e-86	308.00
IUUC-Loc-052517	Lepisosteus oculatus	89.12	1.00e-74	271.00
IUUC-Laf-053986	Loxodonta africana	96.77	1.00e-85	307.00
IUUC-Mcc-054860	Macaca mulatta	96.69	5.00e-82	296.00
IUUC-Meu-056640	Macropus eugenii	79.86	1.00e-60	224.00
IUUC-Mla-059067	Melampsora laricipopulina	38.30	1.00e-08	55.50
IUUC-Mmr-061260	Microcebus murinus	97.22	6.00e-78	282.00
IUUC-Mdo-062793	Monodelphis domestica	90.48	2.00e-76	277.00
IUUC-Mmu-063949	Mus musculus	96.77	2.00e-87	313.00
IUUC-Mpu-066068	Mustela putorius furo	98.71	2.00e-88	317.00
IUUC-Mlu-067176	Myotis lucifugus	98.06	9.00e-88	315.00
IUUC-Nle-069924	Nomascus leucogenys	97.42	2.00e-87	313.00
IUUC-Opr-070985	Ochotona princeps	96.13	4.00e-85	306.00
IUUC-Ont-071718	Oreochromis niloticus	63.50	5.00e-43	166.00
IUUC-Oan-073727	Ornithorhynchus anatinus	89.73	7.00e-76	275.00
IUUC-Ocu-074776	Oryctolagus cuniculus	96.05	8.00e-84	301.00
IUUC-Obr-076171	Oryza brachyantha	44.26	4.00e-12	64.70
IUUC-Ome-081273	Oryza meridionalis	37.14	2.00e-12	65.50
IUUC-Oni-083042	Oryza nivara	52.27	3.00e-11	62.00
IUUC-Opu-083509	Oryza punctata	32.89	7.00e-13	66.60
IUUC-Oru-084685	Oryza rufipogon	52.27	3.00e-11	62.00
IUUC-Ola-087147	Oryzias latipes	87.10	3.00e-79	286.00
IUUC-Oga-087917	Otolemur garnettii	98.06	3.00e-88	316.00
IUUC-Oar-089739	Ovis aries	94.16	6.00e-83	299.00
IUUC-Ptr-090619	Pan troglodytes	100.00	2.00e-89	321.00
IUUC-Pan-092854	Papio anubis	98.71	1.00e-88	318.00
IUUC-Psi-093254	Pelodiscus sinensis	91.20	3.00e-66	244.00
IUUC-Pma-094708	Petromyzon marinus	66.23	2.00e-24	103.00
IUUC-Pfo-096899	Poecilia formosa	87.10	6.00e-79	286.00
IUUC-Pab-097858	Pongo abelii	99.35	6.00e-89	319.00
IUUC-Pca-100210	Procavia capensis	97.42	2.00e-87	313.00
IUUC-Pva-102677	Pteropus vampyrus	96.77	1.00e-85	308.00
IUUC-Rno-105488	Rattus norvegicus	81.68	9.00e-58	215.00
IUUC-Sha-107332	Sarcophilus harrisii	90.54	4.00e-77	280.00
IUUC-Sja-107935	Schizosaccharomyces japonicus	33.93	1.00e-10	60.80
IUUC-Sar-113175	Sorex araneus	94.44	6.00e-57	211.00
IUUC-Ssc-115896	Sus scrofa	98.06	2.00e-86	310.00
IUUC-Tru-118255	Takifugu rubripes	78.71	7.00e-68	249.00
IUUC-Tsy-119575	Tarsius syrichta	98.06	3.00e-88	316.00
IUUC-Tni-120329	Tetraodon nigroviridis	76.13	1.00e-65	241.00
IUUC-Ttr-128649	Tursiops truncatus	98.06	1.00e-87	315.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence