iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000134086.7	ENST00000256474.2	ENSP00000256474.2
ENSG00000134086.7	ENST00000345392.2	ENSP00000344757.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
miRecords	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	20300531; 19228690; 12912922; 19695223; 19305426; 20026589; 11574546; 11739384; 12604794; 17350623; 15777842

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.72	8.00e-04	40.40	IUUC-Dme-031988

Organism

Homo sapiens

Functional Description
(View)

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

Protein Sequence
(Fasta)

MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR 60
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGTGTTTA TGTTTGTAGT TTTAATTGCT CTGAAGTAAA TATCTGATTT TCCAATTTCC 60
ACCAGAGTGC TCTGCACATA GTAGGTCTAA TTATTTTTCC CTCTTTACTA ATCACCCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0985--Congenital erythrocytosis
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0472--Membrane
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0043--Tumor suppressor
KW-0833--Ubl conjugation pathway

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0019899--F:enzyme binding
GO:0008134--F:transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000902--P:cell morphogenesis
GO:0043066--P:negative regulation of apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061428--P:negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0045597--P:positive regulation of cell differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

hsa:7428

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	83.87	2.00e-68	252.00
IUUC-Apl-003580	Anas platyrhynchos	71.43	2.00e-26	110.00
IUUC-Aca-004492	Anolis carolinensis	78.74	4.00e-57	213.00
IUUC-Ang-009806	Aspergillus niger	40.62	1.30e-01	27.30
IUUC-Ame-011818	Astyanax mexicanus	46.80	1.00e-46	179.00
IUUC-Bta-013459	Bos taurus	94.27	3.00e-84	303.00
IUUC-Cel-018173	Caenorhabditis elegans	31.87	9.00e-05	39.70
IUUC-Cja-019826	Callithrix jacchus	97.45	1.00e-86	312.00
IUUC-Cfa-021280	Canis familiaris	94.81	1.00e-82	299.00
IUUC-Cpo-022544	Cavia porcellus	86.03	2.00e-84	304.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	43.33	4.00e-08	52.80
IUUC-Csa-023644	Chlorocebus sabaeus	97.47	6.00e-88	316.00
IUUC-Cho-024479	Choloepus hoffmanni	64.39	7.00e-41	159.00
IUUC-Cin-025505	Ciona intestinalis	27.35	2.00e-05	42.00
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	1.00e-05	43.50
IUUC-Dre-028350	Danio rerio	53.42	4.00e-33	134.00
IUUC-Dno-029207	Dasypus novemcinctus	87.04	6.00e-51	193.00
IUUC-Dor-030912	Dipodomys ordii	66.45	3.00e-50	191.00
IUUC-Dme-031988	Drosophila melanogaster	26.72	2.00e-05	42.40
IUUC-Eca-034007	Equus caballus	97.50	8.00e-19	84.70
IUUC-Fca-036350	Felis catus	94.23	5.00e-82	296.00
IUUC-Fal-037192	Ficedula albicollis	69.33	4.00e-56	210.00
IUUC-Gmo-038921	Gadus morhua	55.97	2.00e-44	171.00
IUUC-Gga-041016	Gallus gallus	69.93	2.00e-55	208.00
IUUC-Gac-042560	Gasterosteus aculeatus	51.05	1.00e-35	142.00
IUUC-Ggo-045419	Gorilla gorilla	99.06	9.00e-91	325.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	95.51	4.00e-85	306.00
IUUC-Lch-050463	Latimeria chalumnae	65.10	6.00e-54	203.00
IUUC-Loc-052053	Lepisosteus oculatus	57.34	2.00e-47	181.00
IUUC-Laf-053893	Loxodonta africana	91.77	1.00e-82	298.00
IUUC-Mcc-055347	Macaca mulatta	64.49	3.00e-64	237.00
IUUC-Mtr-058490	Medicago truncatula	48.48	8.00e-03	33.90
IUUC-Mdo-062169	Monodelphis domestica	75.53	4.00e-38	149.00
IUUC-Mmu-064366	Mus musculus	94.96	8.00e-76	276.00
IUUC-Mpu-066593	Mustela putorius furo	93.59	3.00e-83	301.00
IUUC-Mlu-066926	Myotis lucifugus	88.11	2.00e-86	311.00
IUUC-Nle-069724	Nomascus leucogenys	98.59	8.00e-90	322.00
IUUC-Opr-070679	Ochotona princeps	77.84	6.00e-75	273.00
IUUC-Ont-071332	Oreochromis niloticus	53.38	5.00e-42	163.00
IUUC-Ola-086869	Oryzias latipes	50.65	4.00e-40	157.00
IUUC-Oga-089124	Otolemur garnettii	94.97	2.00e-84	304.00
IUUC-Oar-089799	Ovis aries	90.91	3.00e-49	186.00
IUUC-Ptr-091186	Pan troglodytes	99.01	8.00e-55	205.00
IUUC-Pan-092150	Papio anubis	95.77	3.00e-87	314.00
IUUC-Psi-094039	Pelodiscus sinensis	67.38	1.00e-52	198.00
IUUC-Pma-094129	Petromyzon marinus	47.24	6.00e-27	113.00
IUUC-Pfo-096892	Poecilia formosa	50.35	6.00e-37	146.00
IUUC-Pab-097822	Pongo abelii	99.06	9.00e-90	322.00
IUUC-Pca-101058	Procavia capensis	81.86	6.00e-79	286.00
IUUC-Pva-102932	Pteropus vampyrus	96.84	3.00e-87	314.00
IUUC-Rno-105050	Rattus norvegicus	93.04	1.00e-85	308.00
IUUC-Sha-106738	Sarcophilus harrisii	78.00	1.00e-42	163.00
IUUC-Ssc-115973	Sus scrofa	92.36	5.00e-83	300.00
IUUC-Tgu-116663	Taeniopygia guttata	71.74	1.00e-33	133.00
IUUC-Tru-118654	Takifugu rubripes	56.64	1.00e-42	165.00
IUUC-Tca-121306	Theobroma cacao	38.89	3.90e-02	29.60
IUUC-Ttr-128418	Tursiops truncatus	94.30	2.00e-85	308.00
IUUC-Vpa-130268	Vicugna pacos	90.91	3.00e-48	184.00
IUUC-Xtr-132506	Xenopus tropicalis	66.20	6.00e-55	206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence