iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.90e-08	34.5	418	479

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..............kdgpl......vlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                  +      +++CgH++h+ Cl ++ +++ ++ ++ +CP+C+
   Q: 418  CTICMERLvtasgyegvlrnksV---RpelvgrLGRCGHMYHLLCLVAM-YSNGNKDGSLQCPTCK 479
           9*******888876666654331...1333333799**********666.79999**********6 PP

Organism

Mus musculus

Functional Description
(View)

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Protein Sequence
(Fasta)

MSRPGQGVMV PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV 60
VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA 120

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Nucleotide Sequence
(Fasta)

CTTATGAGCA GTCTTTAGAC TGTCTCTAAA TCAGATTCAT TCATTCAAGT ACTTATTGAG 60
CGCCTGTTGT GTACCAGGCC CTAGCATAGA TGCTAAATGC AAAGATGATA GATTGGAACC 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50918--WWE
PS50089--ZF_RING_2

Pfam

PF02825--WWE
PF00097--zf-C3HC4

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005112--F:Notch binding
GO:0016740--F:transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0010001--P:glial cell differentiation
GO:0045665--P:negative regulation of neuron differentiation
GO:0045581--P:negative regulation of T cell differentiation
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
GO:0008593--P:regulation of Notch signaling pathway

KEGG

mmu:14357

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000830	Aegilops tauschii	31.25	6.00e-05	42.00
IUUC-Aca-005007	Anolis carolinensis	79.87	0.00e+00	988.00
IUUC-Ame-011497	Astyanax mexicanus	71.75	0.00e+00	867.00
IUUC-Bta-012612	Bos taurus	95.06	0.00e+00	1038.00
IUUC-Bdi-014427	Brachypodium distachyon	28.12	3.00e-04	40.00
IUUC-Csa-023525	Chlorocebus sabaeus	95.37	0.00e+00	1025.00
IUUC-Dre-028108	Danio rerio	82.62	4.00e-147	513.00
IUUC-Eca-033826	Equus caballus	90.46	1.00e-154	540.00
IUUC-Fca-036290	Felis catus	92.73	5.00e-155	541.00
IUUC-Gmo-039078	Gadus morhua	81.60	3.00e-156	545.00
IUUC-Gga-040162	Gallus gallus	78.92	0.00e+00	902.00
IUUC-Gac-042521	Gasterosteus aculeatus	74.28	0.00e+00	868.00
IUUC-Ggo-044598	Gorilla gorilla	84.94	0.00e+00	979.00
IUUC-Hsa-046570	Homo sapiens	94.58	0.00e+00	1026.00
IUUC-Hvu-047201	Hordeum vulgare	31.25	7.00e-05	42.00
IUUC-Lch-050642	Latimeria chalumnae	82.85	8.00e-147	512.00
IUUC-Loc-052134	Lepisosteus oculatus	75.74	0.00e+00	934.00
IUUC-Laf-054360	Loxodonta africana	98.49	5.00e-174	604.00
IUUC-Meu-056430	Macropus eugenii	92.46	7.00e-164	570.00
IUUC-Mmr-061378	Microcebus murinus	87.54	2.00e-148	518.00
IUUC-Mpu-066343	Mustela putorius furo	98.06	3.00e-161	561.00
IUUC-Mlu-067905	Myotis lucifugus	93.64	4.00e-162	565.00
IUUC-Nle-069498	Nomascus leucogenys	92.82	0.00e+00	988.00
IUUC-Opr-070885	Ochotona princeps	89.65	0.00e+00	926.00
IUUC-Oan-073617	Ornithorhynchus anatinus	75.05	0.00e+00	652.00
IUUC-Oba-075224	Oryza barthii	27.27	1.00e-05	44.30
IUUC-Ogl-077568	Oryza glaberrima	27.27	1.00e-05	44.30
IUUC-Ogu-077958	Oryza glumaepatula	27.27	1.00e-05	44.30
IUUC-Oin-079699	Oryza indica	27.27	1.00e-05	44.30
IUUC-Ome-081380	Oryza meridionalis	27.27	1.00e-05	44.30
IUUC-Oni-082776	Oryza nivara	27.27	1.00e-05	44.30
IUUC-Opu-083671	Oryza punctata	26.36	9.00e-06	45.10
IUUC-Oru-085146	Oryza rufipogon	27.27	1.00e-05	44.30
IUUC-Osa-085571	Oryza sativa	27.27	1.00e-05	44.30
IUUC-Ola-087219	Oryzias latipes	67.14	0.00e+00	785.00
IUUC-Oga-088768	Otolemur garnettii	95.06	0.00e+00	1019.00
IUUC-Ptr-090522	Pan troglodytes	90.91	0.00e+00	967.00
IUUC-Pan-092352	Papio anubis	94.90	0.00e+00	1028.00
IUUC-Psi-093534	Pelodiscus sinensis	87.32	2.00e-145	507.00
IUUC-Pma-094460	Petromyzon marinus	74.75	8.00e-134	469.00
IUUC-Pab-098315	Pongo abelii	90.75	0.00e+00	956.00
IUUC-Pca-100459	Procavia capensis	97.52	1.00e-107	384.00
IUUC-Pva-102574	Pteropus vampyrus	87.35	5.00e-174	604.00
IUUC-Rno-105607	Rattus norvegicus	99.68	0.00e+00	1064.00
IUUC-Sha-107129	Sarcophilus harrisii	81.12	0.00e+00	1000.00
IUUC-Sit-110693	Setaria italica	23.64	2.00e-05	43.90
IUUC-Ssc-116198	Sus scrofa	93.37	1.00e-162	566.00
IUUC-Tae-125355	Triticum aestivum	24.55	1.00e-05	44.70
IUUC-Ttr-128583	Tursiops truncatus	93.14	0.00e+00	1009.00
IUUC-Vvi-130867	Vitis vinifera	34.38	2.00e-04	40.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence