iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074193

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02024760

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000003686.3	ENSOCUT00000003687.3	ENSOCUP00000003197.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-109	365.8	747	1077

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 747  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 833
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 834  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 920
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 921  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1002
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1003 EsLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1077
           ***********9988...69*************************88888*******************...********8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA QKIFKAAEEC RLDRDEERAY 60
VLYMKFVTVY NLIKKRPDFK QQQDYFHSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAAAGATA CATTTACTGA AGCATAGCAT TCATTGTGAA AATAGGAAAG TAAAAATTAT 60
TCATCATGCC TGCTGTGGCT TCAGTTCCTA AAGAACTCTA CCTCAGTTCT TCACTTAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100351436

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	88.75	0.00e+00	1818.00
IUUC-Apl-003226	Anas platyrhynchos	70.26	0.00e+00	1452.00
IUUC-Aca-004936	Anolis carolinensis	67.85	0.00e+00	1309.00
IUUC-Ago-007959	Ashbya gossypii	35.62	6.00e-55	209.00
IUUC-Acl-008102	Aspergillus clavatus	31.32	1.00e-50	195.00
IUUC-Afl-008604	Aspergillus flavus	31.04	1.00e-49	191.00
IUUC-Afu-009001	Aspergillus fumigatus	31.11	9.00e-50	192.00
IUUC-Ani-009291	Aspergillus nidulans	31.16	2.00e-49	191.00
IUUC-Ang-009844	Aspergillus niger	32.43	6.00e-49	189.00
IUUC-Aor-010098	Aspergillus oryzae	31.04	6.00e-49	189.00
IUUC-Ate-010585	Aspergillus terreus	31.64	7.00e-49	189.00
IUUC-Ame-011029	Astyanax mexicanus	59.44	3.00e-71	261.00
IUUC-Bta-013008	Bos taurus	88.06	0.00e+00	1801.00
IUUC-Bol-015281	Brassica oleracea	38.21	9.00e-47	181.00
IUUC-Bra-017228	Brassica rapa	39.10	1.00e-48	187.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	2.00e-51	197.00
IUUC-Cja-019173	Callithrix jacchus	89.00	0.00e+00	1836.00
IUUC-Cfa-021243	Canis familiaris	88.54	0.00e+00	1817.00
IUUC-Cpo-021522	Cavia porcellus	86.95	0.00e+00	1773.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	1.00e-81	296.00
IUUC-Csa-023616	Chlorocebus sabaeus	89.24	0.00e+00	1542.00
IUUC-Cho-024381	Choloepus hoffmanni	76.98	0.00e+00	1523.00
IUUC-Cin-025287	Ciona intestinalis	49.87	3.00e-98	353.00
IUUC-Csv-026253	Ciona savignyi	47.90	7.00e-87	315.00
IUUC-Cne-026821	Cryptococcus neoformans	39.89	2.00e-74	274.00
IUUC-Dre-028440	Danio rerio	64.56	0.00e+00	742.00
IUUC-Dno-029039	Dasypus novemcinctus	87.29	0.00e+00	1837.00
IUUC-Dor-031043	Dipodomys ordii	96.12	1.00e-132	468.00
IUUC-Dse-031463	Dothistroma septosporum	28.36	1.00e-41	165.00
IUUC-Dme-032089	Drosophila melanogaster	45.17	6.00e-84	305.00
IUUC-Ete-033040	Echinops telfairi	76.19	0.00e+00	1443.00
IUUC-Eca-033449	Equus caballus	88.99	0.00e+00	1830.00
IUUC-Eeu-034693	Erinaceus europaeus	96.12	2.00e-131	463.00
IUUC-Fca-035794	Felis catus	98.32	0.00e+00	926.00
IUUC-Fal-037322	Ficedula albicollis	79.09	0.00e+00	875.00
IUUC-Gmo-038584	Gadus morhua	66.73	0.00e+00	662.00
IUUC-Gga-041188	Gallus gallus	82.21	0.00e+00	907.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.00	0.00e+00	737.00
IUUC-Ggo-045565	Gorilla gorilla	89.27	0.00e+00	1855.00
IUUC-Hsa-046438	Homo sapiens	89.18	0.00e+00	1853.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	92.29	0.00e+00	1865.00
IUUC-Kpa-049321	Komagataella pastoris	33.24	6.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	83.14	0.00e+00	871.00
IUUC-Loc-052769	Lepisosteus oculatus	76.60	0.00e+00	764.00
IUUC-Lma-053021	Leptosphaeria maculans	32.75	4.00e-53	203.00
IUUC-Laf-053432	Loxodonta africana	81.36	0.00e+00	1690.00
IUUC-Mcc-055823	Macaca mulatta	89.09	0.00e+00	1852.00
IUUC-Meu-056099	Macropus eugenii	97.03	6.00e-164	571.00
IUUC-Mla-059089	Melampsora laricipopulina	39.88	2.00e-71	265.00
IUUC-Mga-059739	Meleagris gallopavo	82.03	0.00e+00	902.00
IUUC-Mvi-060559	Microbotryum violaceum	40.84	5.00e-77	283.00
IUUC-Mmr-061158	Microcebus murinus	87.35	0.00e+00	1789.00
IUUC-Mdo-061801	Monodelphis domestica	78.73	0.00e+00	1546.00
IUUC-Mmu-063665	Mus musculus	83.10	0.00e+00	1686.00
IUUC-Mpu-066738	Mustela putorius furo	88.27	0.00e+00	1779.00
IUUC-Mlu-067307	Myotis lucifugus	85.61	0.00e+00	1758.00
IUUC-Nfi-068410	Neosartorya fischeri	31.39	4.00e-50	193.00
IUUC-Nle-069314	Nomascus leucogenys	88.91	0.00e+00	1846.00
IUUC-Opr-070378	Ochotona princeps	84.31	0.00e+00	1286.00
IUUC-Ont-071545	Oreochromis niloticus	73.80	0.00e+00	764.00
IUUC-Oan-073537	Ornithorhynchus anatinus	75.22	0.00e+00	1496.00
IUUC-Ola-086622	Oryzias latipes	75.20	0.00e+00	740.00
IUUC-Oga-088271	Otolemur garnettii	86.61	0.00e+00	1761.00
IUUC-Oar-090431	Ovis aries	88.10	0.00e+00	1809.00
IUUC-Ptr-091339	Pan troglodytes	88.91	0.00e+00	1894.00
IUUC-Pan-091783	Papio anubis	82.48	0.00e+00	929.00
IUUC-Psi-093187	Pelodiscus sinensis	66.04	2.00e-160	559.00
IUUC-Pma-094626	Petromyzon marinus	58.23	2.00e-142	498.00
IUUC-Pfo-096463	Poecilia formosa	75.86	0.00e+00	755.00
IUUC-Pab-097645	Pongo abelii	89.00	0.00e+00	1842.00
IUUC-Pva-103222	Pteropus vampyrus	82.20	0.00e+00	862.00
IUUC-Pgr-103408	Puccinia graminis	35.66	1.00e-53	205.00
IUUC-Ptt-103699	Puccinia triticina	45.80	7.00e-68	252.00
IUUC-Pte-104348	Pyrenophora teres	28.83	3.00e-39	157.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.11	9.00e-51	195.00
IUUC-Rno-105510	Rattus norvegicus	83.47	0.00e+00	1719.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.26	3.00e-51	197.00
IUUC-Sha-106879	Sarcophilus harrisii	85.51	0.00e+00	946.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	4.00e-48	185.00
IUUC-Sar-113019	Sorex araneus	81.11	0.00e+00	1683.00
IUUC-Sre-115031	Sporisorium reilianum	37.33	6.00e-69	256.00
IUUC-Ssc-116334	Sus scrofa	89.37	0.00e+00	1828.00
IUUC-Tgu-117062	Taeniopygia guttata	78.98	0.00e+00	880.00
IUUC-Tru-117908	Takifugu rubripes	59.82	0.00e+00	1176.00
IUUC-Tsy-118867	Tarsius syrichta	82.30	0.00e+00	1005.00
IUUC-Tni-120206	Tetraodon nigroviridis	55.34	0.00e+00	1058.00
IUUC-Tme-127144	Tuber melanosporum	40.00	3.00e-78	286.00
IUUC-Tbe-127877	Tupaia belangeri	85.88	1.00e-86	314.00
IUUC-Ttr-128580	Tursiops truncatus	84.15	0.00e+00	1689.00
IUUC-Uma-129340	Ustilago maydis	37.63	9.00e-71	262.00
IUUC-Vpa-130541	Vicugna pacos	87.47	0.00e+00	1796.00
IUUC-Xtr-132161	Xenopus tropicalis	58.93	0.00e+00	1188.00
IUUC-Xma-134271	Xiphophorus maculatus	73.41	0.00e+00	755.00
IUUC-Yli-134561	Yarrowia lipolytica	35.92	7.00e-60	225.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence