iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116334

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU469118

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000004639.2	ENSSSCT00000005124.2	ENSSSCP00000004999.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-109	365.0	748	1078

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  ++e++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 748  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQEDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 834
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++d  +l+d      a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e 
   Q: 835  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENND--HLDDFkaaeyAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEA 919
           *********************885555555554444..4444444555*************************************** PP
   S: 169  fldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
           f++lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+f
   Q: 920  FMYLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDF 1001
           *************9...******************************************************996.55.6******** PP
   S: 256  ple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           ple Ldl+++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1002 PLEnLDLAQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISISSVKS---SAAYILFYT 1078
           *************9988...69*************************88888*******************...********8 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA LKIFKTAEES RLDRDEERAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFLSIL GPGNIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGCCTCAG CTCAGCGTAG CCTGGTCCGT ACCCATACTG CCCATCTAAA ACATCCGCCT 60
CAGCCCTCCT CCGCCCTCCC ATACCCTCTC ACAGGCGGTG ACCGGGATGG GAAGGAACTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031313--C:extrinsic component of endosome membrane
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	90.20	0.00e+00	1844.00
IUUC-Apl-003226	Anas platyrhynchos	76.05	0.00e+00	897.00
IUUC-Aca-004936	Anolis carolinensis	67.46	0.00e+00	1305.00
IUUC-Ago-007959	Ashbya gossypii	35.89	2.00e-55	211.00
IUUC-Acl-008102	Aspergillus clavatus	31.59	5.00e-53	202.00
IUUC-Afl-008604	Aspergillus flavus	31.32	1.00e-51	197.00
IUUC-Afu-009001	Aspergillus fumigatus	31.39	3.00e-52	200.00
IUUC-Ani-009291	Aspergillus nidulans	30.49	1.00e-51	197.00
IUUC-Ang-009844	Aspergillus niger	32.22	9.00e-52	198.00
IUUC-Aor-010098	Aspergillus oryzae	31.32	7.00e-51	195.00
IUUC-Ate-010585	Aspergillus terreus	31.22	2.00e-51	197.00
IUUC-Ame-011029	Astyanax mexicanus	60.63	1.00e-73	269.00
IUUC-Bta-013008	Bos taurus	93.02	0.00e+00	1866.00
IUUC-Bol-015281	Brassica oleracea	37.91	4.00e-50	192.00
IUUC-Bra-017228	Brassica rapa	38.81	9.00e-52	197.00
IUUC-Cel-018482	Caenorhabditis elegans	33.82	1.00e-53	204.00
IUUC-Cja-019173	Callithrix jacchus	87.95	0.00e+00	1821.00
IUUC-Cfa-021243	Canis familiaris	90.80	0.00e+00	1863.00
IUUC-Cpo-021522	Cavia porcellus	87.06	0.00e+00	1749.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.35	1.00e-85	309.00
IUUC-Csa-023616	Chlorocebus sabaeus	88.95	0.00e+00	1543.00
IUUC-Cho-024381	Choloepus hoffmanni	76.86	0.00e+00	1538.00
IUUC-Cin-025287	Ciona intestinalis	50.13	2.00e-100	360.00
IUUC-Csv-026253	Ciona savignyi	47.79	3.00e-89	323.00
IUUC-Cne-026821	Cryptococcus neoformans	39.89	2.00e-75	278.00
IUUC-Dre-028440	Danio rerio	64.32	0.00e+00	752.00
IUUC-Dno-029039	Dasypus novemcinctus	88.04	0.00e+00	1856.00
IUUC-Dor-031043	Dipodomys ordii	94.83	2.00e-138	486.00
IUUC-Dse-031463	Dothistroma septosporum	28.07	4.00e-44	173.00
IUUC-Dme-032089	Drosophila melanogaster	44.25	1.00e-87	317.00
IUUC-Ete-033040	Echinops telfairi	78.87	0.00e+00	1454.00
IUUC-Eca-033449	Equus caballus	90.44	0.00e+00	1873.00
IUUC-Eeu-034693	Erinaceus europaeus	96.12	5.00e-132	465.00
IUUC-Fca-035794	Felis catus	97.69	0.00e+00	923.00
IUUC-Fal-037322	Ficedula albicollis	78.51	0.00e+00	875.00
IUUC-Gmo-038584	Gadus morhua	66.06	0.00e+00	675.00
IUUC-Gga-041188	Gallus gallus	81.74	0.00e+00	897.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.65	0.00e+00	748.00
IUUC-Ggo-045565	Gorilla gorilla	89.46	0.00e+00	1855.00
IUUC-Hsa-046438	Homo sapiens	89.46	0.00e+00	1855.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	90.37	0.00e+00	1825.00
IUUC-Kpa-049321	Komagataella pastoris	33.51	3.00e-51	196.00
IUUC-Lch-050485	Latimeria chalumnae	82.43	0.00e+00	864.00
IUUC-Loc-052769	Lepisosteus oculatus	76.76	0.00e+00	763.00
IUUC-Lma-053021	Leptosphaeria maculans	32.53	7.00e-57	215.00
IUUC-Laf-053432	Loxodonta africana	82.46	0.00e+00	997.00
IUUC-Mcc-055823	Macaca mulatta	88.75	0.00e+00	1848.00
IUUC-Meu-056099	Macropus eugenii	96.65	4.00e-164	572.00
IUUC-Mla-059089	Melampsora laricipopulina	39.88	2.00e-71	264.00
IUUC-Mga-059739	Meleagris gallopavo	81.74	0.00e+00	892.00
IUUC-Mvi-060559	Microbotryum violaceum	40.11	5.00e-79	289.00
IUUC-Mmr-061158	Microcebus murinus	87.65	0.00e+00	1777.00
IUUC-Mdo-061801	Monodelphis domestica	85.77	0.00e+00	952.00
IUUC-Mmu-063665	Mus musculus	83.23	0.00e+00	1674.00
IUUC-Mpu-066738	Mustela putorius furo	89.72	0.00e+00	1814.00
IUUC-Mlu-067307	Myotis lucifugus	86.26	0.00e+00	1770.00
IUUC-Nfi-068410	Neosartorya fischeri	31.67	1.00e-52	201.00
IUUC-Nle-069314	Nomascus leucogenys	89.20	0.00e+00	1845.00
IUUC-Opr-070378	Ochotona princeps	79.73	0.00e+00	1203.00
IUUC-Ont-071545	Oreochromis niloticus	73.90	0.00e+00	765.00
IUUC-Oan-073537	Ornithorhynchus anatinus	74.58	0.00e+00	1483.00
IUUC-Ocu-074193	Oryctolagus cuniculus	89.64	0.00e+00	1827.00
IUUC-Ola-086622	Oryzias latipes	74.70	0.00e+00	738.00
IUUC-Oga-088271	Otolemur garnettii	87.17	0.00e+00	1776.00
IUUC-Oar-090431	Ovis aries	92.86	0.00e+00	1870.00
IUUC-Ptr-091339	Pan troglodytes	89.11	0.00e+00	1897.00
IUUC-Pan-091783	Papio anubis	82.17	0.00e+00	926.00
IUUC-Psi-093187	Pelodiscus sinensis	65.70	7.00e-160	557.00
IUUC-Pma-094626	Petromyzon marinus	58.23	1.00e-144	505.00
IUUC-Pno-094986	Phaeosphaeria nodorum	30.21	5.00e-40	159.00
IUUC-Pfo-096463	Poecilia formosa	75.71	0.00e+00	760.00
IUUC-Pab-097645	Pongo abelii	89.02	0.00e+00	1847.00
IUUC-Pva-103222	Pteropus vampyrus	84.86	0.00e+00	894.00
IUUC-Pgr-103408	Puccinia graminis	35.39	2.00e-56	214.00
IUUC-Ptt-103699	Puccinia triticina	45.45	8.00e-68	252.00
IUUC-Pte-104348	Pyrenophora teres	28.53	8.00e-42	165.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	29.97	1.00e-52	201.00
IUUC-Rno-105510	Rattus norvegicus	82.77	0.00e+00	1695.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.54	1.00e-52	201.00
IUUC-Sha-106879	Sarcophilus harrisii	84.68	0.00e+00	937.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.00	7.00e-50	191.00
IUUC-Sar-113019	Sorex araneus	81.09	0.00e+00	1710.00
IUUC-Sre-115031	Sporisorium reilianum	37.05	1.00e-69	258.00
IUUC-Tgu-117062	Taeniopygia guttata	78.41	0.00e+00	872.00
IUUC-Tru-117908	Takifugu rubripes	58.99	0.00e+00	1169.00
IUUC-Tsy-118867	Tarsius syrichta	82.91	0.00e+00	1016.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.35	0.00e+00	728.00
IUUC-Tme-127144	Tuber melanosporum	40.00	2.00e-79	290.00
IUUC-Tbe-127877	Tupaia belangeri	97.39	2.00e-84	307.00
IUUC-Ttr-128580	Tursiops truncatus	92.01	0.00e+00	1168.00
IUUC-Uma-129340	Ustilago maydis	36.27	8.00e-72	265.00
IUUC-Vpa-130541	Vicugna pacos	89.71	0.00e+00	1841.00
IUUC-Xtr-132161	Xenopus tropicalis	57.29	0.00e+00	1198.00
IUUC-Xma-134271	Xiphophorus maculatus	73.13	0.00e+00	758.00
IUUC-Yli-134561	Yarrowia lipolytica	35.92	3.00e-60	227.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence