iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000138785.14	ENST00000394735.5	ENSP00000378221.1
ENSG00000138785.14	ENST00000510876.1	ENSP00000422856.1
ENSG00000138785.14	ENST00000618810.4	ENSP00000481164.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.10e-08	35.9	162	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 4    ClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek..wiCpkCrs 53
           C vC++ +  +  +lveC++C++ +H +C+k++v ++  n+ +  w+C +C++
   Q: 162  CVVCRQMMVASGnQLVECQECHNLYHRDCHKPQVTDKEANDPRlvWYCARCTR 214
           ********98866********************999999987799******86 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.

Protein Sequence
(Fasta)

MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPS QKDVEPPKIS 60
STKNISIKQE PKISSSLPSG NNNGKVLTTE KVKKEAEKRP ADKMKSDITE GVDIPKKPRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCCTAATT CCCGAGCCGG GGCGAGTCGC CCTCGGGGGG CCGCGGATGG GGTCCCAGAC 60
TCGCAAGGGC GCGCCCTCTC CGCCTCGGGC GGGCACTCGG AGCCGCTGGA CCGCTCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD

SMART

SM00249--PHD

Gene Ontology

GO:0032039--C:integrator complex
GO:0005654--C:nucleoplasm
GO:0008270--F:zinc ion binding
GO:0016180--P:snRNA processing
GO:0042795--P:snRNA transcription from RNA polymerase II promoter

KEGG

hsa:57117

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001485	Ailuropoda melanoleuca	93.35	5.00e-174	603.00
IUUC-Apl-003539	Anas platyrhynchos	78.59	4.00e-149	521.00
IUUC-Bta-013090	Bos taurus	91.80	6.00e-156	543.00
IUUC-Cja-019984	Callithrix jacchus	97.12	4.00e-174	604.00
IUUC-Cfa-020068	Canis familiaris	93.57	2.00e-178	619.00
IUUC-Cpo-021446	Cavia porcellus	87.80	2.00e-142	499.00
IUUC-Csa-023385	Chlorocebus sabaeus	98.89	3.00e-180	624.00
IUUC-Cho-025018	Choloepus hoffmanni	93.57	6.00e-164	570.00
IUUC-Dre-027546	Danio rerio	64.04	4.00e-95	342.00
IUUC-Dno-029989	Dasypus novemcinctus	93.35	1.00e-161	563.00
IUUC-Eca-033999	Equus caballus	90.24	8.00e-161	560.00
IUUC-Fca-035522	Felis catus	94.90	4.00e-169	587.00
IUUC-Gga-041056	Gallus gallus	75.55	4.00e-147	514.00
IUUC-Gac-042508	Gasterosteus aculeatus	59.05	1.00e-87	317.00
IUUC-Ggo-044647	Gorilla gorilla	99.75	2.00e-140	492.00
IUUC-Loc-052933	Lepisosteus oculatus	70.87	7.00e-98	350.00
IUUC-Laf-054471	Loxodonta africana	92.90	3.00e-173	601.00
IUUC-Mcc-055568	Macaca mulatta	98.89	3.00e-180	624.00
IUUC-Meu-056037	Macropus eugenii	89.24	1.00e-152	532.00
IUUC-Mga-059569	Meleagris gallopavo	74.67	8.00e-145	506.00
IUUC-Mmr-061180	Microcebus murinus	95.12	3.00e-166	577.00
IUUC-Mdo-062528	Monodelphis domestica	86.88	1.00e-156	546.00
IUUC-Mmu-064122	Mus musculus	91.13	5.00e-153	534.00
IUUC-Mpu-066477	Mustela putorius furo	94.24	8.00e-166	576.00
IUUC-Mlu-067391	Myotis lucifugus	94.01	4.00e-163	567.00
IUUC-Nle-069599	Nomascus leucogenys	99.56	4.00e-165	574.00
IUUC-Opr-070713	Ochotona princeps	90.91	2.00e-142	498.00
IUUC-Ont-072565	Oreochromis niloticus	63.17	2.00e-82	299.00
IUUC-Oan-073115	Ornithorhynchus anatinus	84.39	1.00e-110	392.00
IUUC-Ocu-074717	Oryctolagus cuniculus	94.24	3.00e-162	564.00
IUUC-Ola-087458	Oryzias latipes	68.20	3.00e-86	312.00
IUUC-Oga-088704	Otolemur garnettii	95.34	3.00e-164	571.00
IUUC-Oar-089184	Ovis aries	92.90	7.00e-158	550.00
IUUC-Ptr-091021	Pan troglodytes	99.56	3.00e-177	614.00
IUUC-Pan-091963	Papio anubis	98.89	3.00e-180	624.00
IUUC-Psi-093012	Pelodiscus sinensis	79.25	2.00e-142	499.00
IUUC-Pab-097870	Pongo abelii	99.56	1.00e-172	599.00
IUUC-Pca-100164	Procavia capensis	92.24	4.00e-169	587.00
IUUC-Pva-102873	Pteropus vampyrus	94.46	3.00e-163	568.00
IUUC-Rno-104840	Rattus norvegicus	90.47	1.00e-147	516.00
IUUC-Sha-106551	Sarcophilus harrisii	85.56	5.00e-154	537.00
IUUC-Tsy-119236	Tarsius syrichta	88.47	2.00e-168	585.00
IUUC-Tni-120510	Tetraodon nigroviridis	64.38	2.00e-95	343.00
IUUC-Tbe-127947	Tupaia belangeri	85.37	4.00e-143	501.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence