iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032376.12	ENSMUST00000127569.7	ENSMUSP00000122199.1
ENSMUSG00000032376.12	ENSMUST00000139547.7	ENSMUSP00000115620.1
ENSMUSG00000032376.12	ENSMUST00000098613.8	ENSMUSP00000096213.2
ENSMUSG00000032376.12	ENSMUST00000174387.1	ENSMUSP00000134472.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-99	333.1	159	510
UBD/ZnF/ZnF_UBP	8.70e-27	94.3	27	104

Active Site

Position(s)	Description	Evidence
168	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
471	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDSNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 247
           7******************************888888777775555555556688999******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************77444444444444444444.45688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+ L+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHLKRFHWTA--YLRN 422
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++v+fpl+ Ld++ ++ +pe++  +++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt+++ee+v +   ++aY+lf
   Q: 423  KVDTYVQFPLRgLDMKCYLLEPENSGPDSCLYDLAAVVVHHGsGVGSGHYTAYAVH-EGRWFHFNDSTVTVTDEETVGK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLlnhkrsekqekaqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP

Organism

Mus musculus

Functional Description
(View)

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity).

Protein Sequence
(Fasta)

MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQIPLLN HKRSEKQEKA QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGGGCCG CCGGAGAAGG CGGAAGCCTA CTGTCCCTGG GCGGCGGCAG AACCAGGAGT 60
CCGGATTTTC ACGTTCTCCG GAGCGGGGCG CCGGGAGACG GCGGATGGCA AAACCCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042393--F:histone binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:235441

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	96.35	0.00e+00	942.00
IUUC-Apl-003358	Anas platyrhynchos	94.29	0.00e+00	888.00
IUUC-Aca-004454	Anolis carolinensis	90.62	0.00e+00	815.00
IUUC-Ame-011544	Astyanax mexicanus	76.32	0.00e+00	735.00
IUUC-Bta-012738	Bos taurus	96.16	0.00e+00	922.00
IUUC-Cel-018186	Caenorhabditis elegans	36.49	3.00e-54	206.00
IUUC-Cja-018893	Callithrix jacchus	97.31	0.00e+00	945.00
IUUC-Cfa-020607	Canis familiaris	96.35	0.00e+00	925.00
IUUC-Cpo-021828	Cavia porcellus	95.38	0.00e+00	916.00
IUUC-Csa-023884	Chlorocebus sabaeus	97.41	0.00e+00	771.00
IUUC-Cho-024863	Choloepus hoffmanni	86.15	0.00e+00	799.00
IUUC-Dre-028452	Danio rerio	73.66	0.00e+00	746.00
IUUC-Dno-029531	Dasypus novemcinctus	95.71	0.00e+00	860.00
IUUC-Dor-030913	Dipodomys ordii	89.52	3.00e-177	614.00
IUUC-Ete-032611	Echinops telfairi	90.58	0.00e+00	872.00
IUUC-Eca-033622	Equus caballus	96.33	0.00e+00	861.00
IUUC-Eeu-035268	Erinaceus europaeus	91.41	0.00e+00	790.00
IUUC-Fca-035801	Felis catus	95.71	0.00e+00	892.00
IUUC-Fal-036749	Ficedula albicollis	94.50	0.00e+00	851.00
IUUC-Gmo-039598	Gadus morhua	76.71	0.00e+00	768.00
IUUC-Gga-040883	Gallus gallus	94.49	0.00e+00	854.00
IUUC-Gac-042235	Gasterosteus aculeatus	75.05	0.00e+00	734.00
IUUC-Ggo-044767	Gorilla gorilla	91.04	0.00e+00	830.00
IUUC-Hsa-046581	Homo sapiens	96.54	0.00e+00	962.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	96.92	0.00e+00	930.00
IUUC-Lch-049732	Latimeria chalumnae	89.42	0.00e+00	902.00
IUUC-Loc-052371	Lepisosteus oculatus	88.27	0.00e+00	894.00
IUUC-Laf-054565	Loxodonta africana	96.15	0.00e+00	925.00
IUUC-Mcc-055522	Macaca mulatta	96.92	0.00e+00	967.00
IUUC-Meu-056754	Macropus eugenii	86.03	3.00e-176	611.00
IUUC-Mga-060095	Meleagris gallopavo	94.36	0.00e+00	636.00
IUUC-Mmr-060839	Microcebus murinus	96.73	0.00e+00	927.00
IUUC-Mdo-062339	Monodelphis domestica	96.55	0.00e+00	751.00
IUUC-Mpu-066647	Mustela putorius furo	96.55	0.00e+00	749.00
IUUC-Mlu-067921	Myotis lucifugus	94.90	0.00e+00	875.00
IUUC-Nle-069752	Nomascus leucogenys	97.31	0.00e+00	969.00
IUUC-Opr-070636	Ochotona princeps	82.12	0.00e+00	728.00
IUUC-Ont-071638	Oreochromis niloticus	75.58	0.00e+00	692.00
IUUC-Oan-073417	Ornithorhynchus anatinus	89.04	0.00e+00	879.00
IUUC-Ocu-074620	Oryctolagus cuniculus	96.15	0.00e+00	925.00
IUUC-Ola-087281	Oryzias latipes	77.65	3.00e-179	620.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.67	1.00e-47	183.00
IUUC-Oga-088448	Otolemur garnettii	95.77	0.00e+00	953.00
IUUC-Oar-090132	Ovis aries	96.15	0.00e+00	926.00
IUUC-Ptr-090696	Pan troglodytes	96.54	0.00e+00	902.00
IUUC-Pan-092124	Papio anubis	96.54	0.00e+00	962.00
IUUC-Psi-093801	Pelodiscus sinensis	94.71	0.00e+00	739.00
IUUC-Pma-094472	Petromyzon marinus	72.37	2.00e-94	338.00
IUUC-Pfo-096330	Poecilia formosa	78.40	0.00e+00	776.00
IUUC-Pab-098191	Pongo abelii	97.12	0.00e+00	968.00
IUUC-Pca-100341	Procavia capensis	95.85	0.00e+00	722.00
IUUC-Pva-103177	Pteropus vampyrus	95.96	0.00e+00	912.00
IUUC-Rno-105048	Rattus norvegicus	98.28	0.00e+00	913.00
IUUC-Sha-107429	Sarcophilus harrisii	95.17	0.00e+00	862.00
IUUC-Sar-113024	Sorex araneus	94.46	0.00e+00	805.00
IUUC-Ssc-115749	Sus scrofa	96.44	2.00e-151	527.00
IUUC-Tgu-117277	Taeniopygia guttata	94.29	0.00e+00	885.00
IUUC-Tru-117844	Takifugu rubripes	77.74	0.00e+00	771.00
IUUC-Tsy-119456	Tarsius syrichta	94.48	0.00e+00	860.00
IUUC-Tni-120251	Tetraodon nigroviridis	74.14	0.00e+00	788.00
IUUC-Tbe-127423	Tupaia belangeri	91.35	0.00e+00	849.00
IUUC-Ttr-128401	Tursiops truncatus	89.37	0.00e+00	779.00
IUUC-Vpa-130549	Vicugna pacos	88.32	2.00e-164	571.00
IUUC-Xtr-131892	Xenopus tropicalis	82.80	0.00e+00	795.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence