iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000053483.13	ENSMUST00000065941.11	ENSMUSP00000064002.5
ENSMUSG00000053483.13	ENSMUST00000149187.7	ENSMUSP00000120161.1
ENSMUSG00000053483.13	ENSMUST00000111306.9	ENSMUSP00000106938.3
ENSMUSG00000053483.13	ENSMUST00000174720.1	ENSMUSP00000133362.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Post-translational Modifications (PTMs)
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-87	294.0	212	560

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNt...CYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeef 84
           +Gl+NlgNt   C++N+vLQcLs++++lr+++l+  ++++++     ++ +el++++++++ +lw  ++ +av+p+++ ++++k+ ++f
   Q: 212  VGLRNLGNTlpqCFLNAVLQCLSSTRPLRDFCLRrDFRQEVPG---GGRAQELTEAFADVIGALWhPDSCEAVNPTRFRAVFQKYVPSF 297
           6*******9999**********************667777776...5789***************888899****************** PP
   S: 85   sgyeqqDaqEflaflldqleeelkk...................eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqi 154
           sgy+qqDaqEfl+ l+++l+ e+++                   +     +ee e ++ ++ +  +++  ++++s i+dlF gqlks +
   Q: 298  SGYSQQDAQEFLKLLMERLHLEINRrgrrappilasgpvpsppcRGGGALHEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCL 386
           ***********************999988999988888888777444444444444445566779************************ PP
   S: 155  kclecdnvssreepfldlslpvpgkeet.kkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
           kc++c+ +s+++e f+dlslp+p+k     k sl+dc++ ftkeeele+en+  c++c++k++++kkl+++++P++L+lhL+Rf  s +
   Q: 387  KCQACGYRSTTFEVFCDLSLPIPKKGFAgGKVSLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF--STS 473
           ***********************887541456****************************************************..666 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgsta 330
           ++s +k +  v+fpl+ L+l  f +++      +  Y+L+a ++HsGs++ GHY+a+++  + +W  ++Ds+V++v+e++v +   s++
   Q: 474  RGSIKKSSVGVDFPLQrLSLGDFASDKAG----SPVYQLYALCNHSGSVHYGHYTALCRC-QTGWHVYNDSRVSPVSENQVAS---SEG 554
           79999**********99*******99543....78*************************.777*******************...*** PP
   S: 331  YvlfYk 336
           YvlfY+
   Q: 555  YVLFYQ 560
           *****8 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MPQASEHRLG RTREPPVNVQ PRVGAKIPFP PRARSKERRN PVPGPNSMLR PLPPRPGPPD 60
ERLKKLELGR GRTSGSRPRG PLRADHGVPL PGSPPPAVAL PLPSRTNLAR SKSVSSGDLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTCCGAGT GTGGGCGCGC AGGCGCCTAA GAGACTGTGA AGCCGGTGGC CGGTGGCCGG 60
GCGGCACCAA CAAAGATGGC GGCGGCCCTT GCGGCGGGAG CAAGCTGGGC AACAGCTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001858	Ailuropoda melanoleuca	95.43	0.00e+00	966.00
IUUC-Aca-004612	Anolis carolinensis	58.67	6.00e-172	597.00
IUUC-Ame-011548	Astyanax mexicanus	51.68	2.00e-101	362.00
IUUC-Bta-012626	Bos taurus	95.08	0.00e+00	939.00
IUUC-Cja-018853	Callithrix jacchus	95.78	0.00e+00	991.00
IUUC-Cfa-021167	Canis familiaris	95.96	0.00e+00	956.00
IUUC-Cpo-021305	Cavia porcellus	95.44	0.00e+00	945.00
IUUC-Csa-023454	Chlorocebus sabaeus	95.96	0.00e+00	989.00
IUUC-Cho-024836	Choloepus hoffmanni	95.34	4.00e-106	378.00
IUUC-Dre-028454	Danio rerio	53.07	8.00e-106	377.00
IUUC-Dno-029955	Dasypus novemcinctus	89.69	4.00e-174	604.00
IUUC-Dor-031053	Dipodomys ordii	95.08	0.00e+00	1004.00
IUUC-Ete-032416	Echinops telfairi	93.66	2.00e-140	492.00
IUUC-Eca-033817	Equus caballus	94.38	0.00e+00	969.00
IUUC-Fca-036400	Felis catus	93.70	0.00e+00	946.00
IUUC-Gmo-038926	Gadus morhua	53.63	2.00e-102	365.00
IUUC-Gac-041331	Gasterosteus aculeatus	52.46	2.00e-105	375.00
IUUC-Ggo-045174	Gorilla gorilla	95.96	0.00e+00	989.00
IUUC-Hsa-046443	Homo sapiens	95.78	0.00e+00	982.00
IUUC-Itr-048329	Ictidomys tridecemlineatus	96.13	0.00e+00	989.00
IUUC-Lch-050539	Latimeria chalumnae	61.76	9.00e-106	377.00
IUUC-Loc-051808	Lepisosteus oculatus	54.92	3.00e-113	401.00
IUUC-Laf-053730	Loxodonta africana	93.18	0.00e+00	975.00
IUUC-Mcc-055541	Macaca mulatta	95.96	0.00e+00	989.00
IUUC-Meu-056279	Macropus eugenii	89.12	0.00e+00	924.00
IUUC-Mmr-060913	Microcebus murinus	95.78	0.00e+00	937.00
IUUC-Mdo-061807	Monodelphis domestica	89.65	0.00e+00	877.00
IUUC-Mpu-066329	Mustela putorius furo	95.96	0.00e+00	954.00
IUUC-Mlu-067359	Myotis lucifugus	92.80	0.00e+00	853.00
IUUC-Nle-068975	Nomascus leucogenys	93.67	0.00e+00	961.00
IUUC-Opr-071096	Ochotona princeps	93.85	0.00e+00	929.00
IUUC-Ocu-074228	Oryctolagus cuniculus	96.49	0.00e+00	966.00
IUUC-Ola-086684	Oryzias latipes	49.86	8.00e-100	357.00
IUUC-Oga-088007	Otolemur garnettii	77.89	0.00e+00	756.00
IUUC-Oar-090226	Ovis aries	94.62	0.00e+00	728.00
IUUC-Ptr-091522	Pan troglodytes	95.96	0.00e+00	989.00
IUUC-Pan-091954	Papio anubis	95.61	0.00e+00	982.00
IUUC-Psi-093216	Pelodiscus sinensis	60.13	0.00e+00	665.00
IUUC-Pfo-096257	Poecilia formosa	49.58	2.00e-100	358.00
IUUC-Pab-098691	Pongo abelii	95.78	0.00e+00	988.00
IUUC-Pca-101133	Procavia capensis	87.35	0.00e+00	909.00
IUUC-Pva-102681	Pteropus vampyrus	92.27	0.00e+00	900.00
IUUC-Rno-105132	Rattus norvegicus	97.72	0.00e+00	976.00
IUUC-Sha-107145	Sarcophilus harrisii	89.46	0.00e+00	843.00
IUUC-Ssc-115586	Sus scrofa	95.96	0.00e+00	940.00
IUUC-Tgu-117491	Taeniopygia guttata	80.66	3.00e-113	400.00
IUUC-Tni-120746	Tetraodon nigroviridis	51.32	3.00e-93	335.00
IUUC-Tbe-127465	Tupaia belangeri	98.14	3.00e-125	442.00
IUUC-Ttr-128274	Tursiops truncatus	92.97	0.00e+00	909.00
IUUC-Xtr-131989	Xenopus tropicalis	49.15	1.00e-126	446.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence