iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Post-translational Modifications (PTMs)
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	9.90e-06	27.2	11	74
E3 activity/RING/RING	8.60e-05	24.6	15	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltlrrli 65
           +e+ C I l+   dPv++++G+++ r ++  +l  ++ ++   cP +r+p  + d++ n+ l++l+
   Q: 11   KELTCVICLNYLVDPVTICCGHSFCRPCL--CLswEEAQSpaNCPACREPSPKMDFKTNILLKNLV 74
           6899************************9..553333333579********************997 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iCl+ + d p++  CgH f++ Cl   w     +++  ++CP Cr
   Q: 15   CVICLNYLVD-PVTICCGHSFCRPCLcLSW----EEAQSPANCPACR 56
           **********.999****************....8899999*****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP 60
KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGAGTAGC TTTGCAACTG GCTTTGGGGA CTTCCGAAAG CTACCAGCAC TGCACTGTGA 60
GACTCTCATC CCTGAGCTGA ATTCATCTGA TTCGACGGCA AGCTTTGGTG AGAACATAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding

KEGG

hsa:129868

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012834	Bos taurus	46.71	2.00e-110	392.00
IUUC-Cja-019010	Callithrix jacchus	73.75	0.00e+00	658.00
IUUC-Cfa-020435	Canis familiaris	49.78	2.00e-114	405.00
IUUC-Csa-024131	Chlorocebus sabaeus	87.39	0.00e+00	810.00
IUUC-Cho-024585	Choloepus hoffmanni	63.39	4.00e-168	584.00
IUUC-Dno-029845	Dasypus novemcinctus	62.72	2.00e-164	572.00
IUUC-Dor-030118	Dipodomys ordii	51.35	1.00e-119	422.00
IUUC-Eca-033627	Equus caballus	60.90	5.00e-155	540.00
IUUC-Fca-035378	Felis catus	52.13	3.00e-120	425.00
IUUC-Ggo-044625	Gorilla gorilla	97.97	1.00e-143	502.00
IUUC-Laf-053917	Loxodonta africana	63.70	1.00e-164	572.00
IUUC-Mcc-054788	Macaca mulatta	87.44	0.00e+00	807.00
IUUC-Mmr-061646	Microcebus murinus	59.29	2.00e-145	508.00
IUUC-Mmu-064071	Mus musculus	42.44	1.00e-92	333.00
IUUC-Mlu-067801	Myotis lucifugus	57.14	9.00e-141	493.00
IUUC-Nle-069150	Nomascus leucogenys	91.48	0.00e+00	827.00
IUUC-Opr-070996	Ochotona princeps	51.46	6.00e-124	437.00
IUUC-Ocu-074806	Oryctolagus cuniculus	59.96	1.00e-151	530.00
IUUC-Oga-088482	Otolemur garnettii	62.44	3.00e-164	571.00
IUUC-Oar-089186	Ovis aries	48.46	1.00e-109	390.00
IUUC-Ptr-090899	Pan troglodytes	97.76	0.00e+00	915.00
IUUC-Pan-092427	Papio anubis	88.12	7.00e-160	556.00
IUUC-Pab-098214	Pongo abelii	94.17	0.00e+00	882.00
IUUC-Pca-100275	Procavia capensis	58.65	2.00e-127	448.00
IUUC-Rno-105981	Rattus norvegicus	47.20	4.00e-108	385.00
IUUC-Smo-109430	Selaginella moellendorffii	43.55	1.00e-09	57.40
IUUC-Ssc-115481	Sus scrofa	51.66	3.00e-130	458.00
IUUC-Tsy-118839	Tarsius syrichta	75.56	0.00e+00	663.00
IUUC-Tbe-128068	Tupaia belangeri	54.01	1.00e-72	266.00
IUUC-Ttr-129012	Tursiops truncatus	42.81	2.00e-60	226.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence