iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000144681.10	ENST00000273183.7	ENSP00000273183.3
ENSG00000144681.10	ENST00000457375.6	ENSP00000393713.2
ENSG00000144681.10	ENST00000427486.5	ENSP00000397521.1
ENSG00000144681.10	ENST00000434649.1	ENSP00000398403.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-15	58.3	286	343

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++  +ly + +q++++L+++ Gd+++++  e+ +e+W+kg  + + + G+fP+nFv++l+
   Q: 286  QMNTYVALYKFVPQENEDLEMRPGDIITLL--EDSNEDWWKG--KIQDRIGFFPANFVQRLQ 343
           678999************************..999*******..8***************97 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF 60
FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGCCCGC TCGCCCGCTG CCGAGTGGCA GTCACGACTG TGAGGTCGCC GGCGAGGTGG 60
CCGCGGGCGC GGCGGGGCGG GGCAGGGCGC ACTCTCCTCC ACGCCCGCGG AAGTGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002219--PE/DAG-bd
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3

PROSITE

PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA

SMART

SM00109--C1
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0030315--C:T-tubule
GO:0046872--F:metal ion binding
GO:0034605--P:cellular response to heat
GO:0035556--P:intracellular signal transduction
GO:0006936--P:muscle contraction
GO:1901385--P:regulation of voltage-gated calcium channel activity
GO:0007165--P:signal transduction

KEGG

hsa:6769

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002138	Ailuropoda melanoleuca	87.47	0.00e+00	653.00
IUUC-Apl-003909	Anas platyrhynchos	74.19	2.00e-160	558.00
IUUC-Aca-005108	Anolis carolinensis	76.04	3.00e-85	307.00
IUUC-Ame-011702	Astyanax mexicanus	60.10	1.00e-129	456.00
IUUC-Bta-013252	Bos taurus	92.08	0.00e+00	710.00
IUUC-Cja-018981	Callithrix jacchus	96.02	0.00e+00	723.00
IUUC-Cfa-020616	Canis familiaris	89.36	0.00e+00	643.00
IUUC-Cpo-021624	Cavia porcellus	89.10	0.00e+00	628.00
IUUC-Csa-023048	Chlorocebus sabaeus	98.63	0.00e+00	697.00
IUUC-Cho-024761	Choloepus hoffmanni	80.74	0.00e+00	639.00
IUUC-Dno-028867	Dasypus novemcinctus	86.91	0.00e+00	650.00
IUUC-Ete-033109	Echinops telfairi	87.10	2.00e-175	608.00
IUUC-Eca-033427	Equus caballus	92.57	0.00e+00	673.00
IUUC-Fca-036129	Felis catus	90.68	0.00e+00	639.00
IUUC-Fal-037364	Ficedula albicollis	78.22	5.00e-155	540.00
IUUC-Gga-040761	Gallus gallus	77.09	1.00e-174	605.00
IUUC-Gac-042076	Gasterosteus aculeatus	60.59	6.00e-132	463.00
IUUC-Ggo-044836	Gorilla gorilla	100.00	4.00e-159	553.00
IUUC-Itr-048358	Ictidomys tridecemlineatus	92.11	0.00e+00	678.00
IUUC-Lch-049737	Latimeria chalumnae	75.27	1.00e-113	402.00
IUUC-Loc-051865	Lepisosteus oculatus	70.13	1.00e-151	529.00
IUUC-Laf-053927	Loxodonta africana	90.57	0.00e+00	692.00
IUUC-Mcc-054821	Macaca mulatta	97.76	0.00e+00	756.00
IUUC-Mga-059635	Meleagris gallopavo	78.34	5.00e-146	510.00
IUUC-Mmr-061072	Microcebus murinus	95.02	0.00e+00	703.00
IUUC-Mmu-063555	Mus musculus	82.92	0.00e+00	640.00
IUUC-Mpu-066475	Mustela putorius furo	91.21	1.00e-156	545.00
IUUC-Mlu-068166	Myotis lucifugus	86.34	0.00e+00	628.00
IUUC-Nle-069985	Nomascus leucogenys	98.76	0.00e+00	768.00
IUUC-Opr-070930	Ochotona princeps	71.04	1.00e-135	476.00
IUUC-Ont-072501	Oreochromis niloticus	56.85	5.00e-132	464.00
IUUC-Oan-072818	Ornithorhynchus anatinus	82.12	6.00e-133	466.00
IUUC-Ocu-074488	Oryctolagus cuniculus	91.04	6.00e-166	576.00
IUUC-Ola-087078	Oryzias latipes	56.97	1.00e-126	446.00
IUUC-Oga-088176	Otolemur garnettii	93.07	0.00e+00	668.00
IUUC-Oar-090183	Ovis aries	87.19	0.00e+00	666.00
IUUC-Ptr-091139	Pan troglodytes	99.75	0.00e+00	776.00
IUUC-Pan-092571	Papio anubis	98.01	0.00e+00	757.00
IUUC-Psi-093399	Pelodiscus sinensis	78.08	4.00e-178	617.00
IUUC-Pma-094266	Petromyzon marinus	52.25	2.00e-105	375.00
IUUC-Pfo-096207	Poecilia formosa	60.74	7.00e-111	393.00
IUUC-Pab-097825	Pongo abelii	99.00	0.00e+00	769.00
IUUC-Pva-102481	Pteropus vampyrus	88.68	8.00e-157	546.00
IUUC-Rno-105553	Rattus norvegicus	83.97	1.00e-169	588.00
IUUC-Sha-106561	Sarcophilus harrisii	70.49	1.00e-139	489.00
IUUC-Sar-113303	Sorex araneus	89.49	7.00e-163	566.00
IUUC-Ssc-116135	Sus scrofa	91.03	0.00e+00	640.00
IUUC-Tgu-116598	Taeniopygia guttata	77.83	2.00e-177	615.00
IUUC-Tsy-118889	Tarsius syrichta	95.77	0.00e+00	710.00
IUUC-Tni-120208	Tetraodon nigroviridis	58.17	8.00e-129	453.00
IUUC-Ttr-128655	Tursiops truncatus	81.89	1.00e-175	609.00
IUUC-Vpa-130814	Vicugna pacos	93.84	7.00e-81	294.00
IUUC-Xtr-132129	Xenopus tropicalis	62.12	4.00e-122	431.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence