iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000151692.14	ENST00000320892.10	ENSP00000321330.6
ENSG00000151692.14	ENST00000416587.5	ENSP00000414420.1
ENSG00000151692.14	ENST00000433456.1	ENSP00000402645.1
ENSG00000151692.14	ENST00000432850.1	ENSP00000411616.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
CPLM	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	24979766; 26216882

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	1.20e-54	185.8	20	214

Active Site

Position(s)	Description	Evidence
198	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl e++ve++t++++C+++fC+ Clkqy+el ikeg +t+iscp+a+cp++  l+e+ei++ +v +e+++ry+kl++e++v  d+++
   Q: 20   CKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQghLQENEIEC-MVAAEIMQRYKKLQFEREVLFDPCR 108
           ****************************************************98889*******.89*********************** PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcpa++C++v++l++ +  + + v+c++c++efC++Ck++wH+g+ C e++  +     e+++a ++e  +a +k+CpkCkvyie++eg
   Q: 109  TWCPASTCQAVCQLQDVGlqTPQPVQCKACRMEFCSTCKASWHPGQGCPETMPITFLPG-ETSAAFKMEEDDAPIKRCPKCKVYIERDEG 197
           ****************8777889999*******************************99.5599999*********************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 198  CAQMMCKNCKHAFCWYC 214
           ***************** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

Protein Sequence
(Fasta)

MTTTRYRPTW DLALDPLVSC KLCLGEYPVE QMTTIAQCQC IFCTLCLKQY VELLIKEGLE 60
TAISCPDAAC PKQGHLQENE IECMVAAEIM QRYKKLQFER EVLFDPCRTW CPASTCQAVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCTCCCG CGTGCCCGGC CTCTGTGCGC GCTCGCGCCC CGCCCGCGCA GCCGCTTCTC 60
CCCGCGCGGG CTCTCGGCAG GCGGGAGGCG GCAGGGCTGG CATTGCAGTG CGGGCCGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:9781

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence