iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000154914.16	ENST00000570475.5	ENSP00000458963.1
ENSG00000154914.16	ENST00000285199.11	ENSP00000285199.6
ENSG00000154914.16	ENST00000574408.5	ENSP00000459328.3
ENSG00000154914.16	ENST00000573955.1	ENSP00000477318.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	11788588; 21298066

Classification

Family	E-value	Score	Start	End
DUB/USP	1.50e-91	308.7	101	710

Active Site

Position(s)	Description	Evidence
110	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
668	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +GlkN+gNtC+mN+v+QcLsn+  l+e+l     ++ +        +e++++l+ l+++lw+++ +     e+++a++k+ ++f+g++q+Da
   Q: 101  QGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPG------RAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDA 186
           6****************************9955555555......479******************************************** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsde..aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet 182
            Efl +lld+++e+l+ +++ p++e+   + +++s++  +++ +   ++s+++  Fq q++s+++c++c ++s++++pfl +slp+p ++++
   Q: 187  LEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENclSPSAQLPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPIPLRQTR 278
           ***************999999999998888888888777889999999******************************************98 PP
   S: 183  kke......................................................................................... 185
            ++                                                                                         
   Q: 279  FLSvtlvfpsksqrflrvglavpilstvaalrkmvaeeggvpadevilvelypsgfqrsffdeedlntiaegdnvyafqvppspsqgtlsah 370
           888***************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 371  plglsasprlaaregqrfslslhseskvlilfcnlvgsgqqasrfgppfliredravswaqlqqsilskvrhlmkseapvqnlgslfsirvv 462
           ******************************************************************************************** PP
   S: 186  ..............................................................................slqdcLesftkeee 199
                                                                                         +l++c++ +tkee+
   Q: 463  glsvacsylspkdsrplchwavdrvlhlrrpggpphvklavewdssvkerlfgslqeeraqdadsvwqqqqahqqhscTLDECFQFYTKEEQ 554
           ******************************************************************************************** PP
   S: 200  legenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekqke................ 274
           l ++++++c++c+ +q+   kl+l++lP++Li+hLkRf   + +++r+k+++ v+fpl+ L+++p++++++++ +                 
   Q: 555  LAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRF--CQVGERRNKLSTLVKFPLSgLNMAPHVAQRSTSPEAglgpwpswkqpdclpt 644
           **************************************..88899************************7777766999999999999999* PP
   S: 275  ....kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
               +  Y+L+av++H+G+l++GHY+ay++n  +g+W+ +dDs+V++++e+ev++   + aY+lfY++r
   Q: 645  syplDFLYDLYAVCNHHGNLQGGHYTAYCRNsLDGQWYSYDDSTVEPLREDEVNT---RGAYILFYQKR 710
           *999***************************55788*******************...********985 PP

Organism

Homo sapiens

Functional Description
(View)

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MDLGPGDAAG GGPLAPRPRR RRSLRRLFSR FLLALGSRSR PGDSPPRPQP GHCDGDGEGG 60
FACAPGPVPA APGSPGEERP PGPQPQLQLP AGDGARPPGA QGLKNHGNTC FMNAVVQCLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACCGCGTA GGGGGCGCGC CTGAGAGCCT GAAAACTTCC TGGTTAGCAA ATACTGAGGC 60
TGGAAAGGGC CTGAACTTGG CAGTCCATAG ATCCAGGTCG AGTTCCGGTT TCCCTGCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:124739

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001922	Ailuropoda melanoleuca	78.15	0.00e+00	1451.00
IUUC-Aca-004436	Anolis carolinensis	53.87	0.00e+00	803.00
IUUC-Ame-011153	Astyanax mexicanus	50.63	0.00e+00	885.00
IUUC-Bta-013560	Bos taurus	80.14	0.00e+00	1583.00
IUUC-Cja-018737	Callithrix jacchus	92.98	0.00e+00	1877.00
IUUC-Cfa-020347	Canis familiaris	77.29	0.00e+00	1470.00
IUUC-Csa-023656	Chlorocebus sabaeus	98.45	0.00e+00	1961.00
IUUC-Cho-024864	Choloepus hoffmanni	72.16	0.00e+00	916.00
IUUC-Dre-028066	Danio rerio	50.09	0.00e+00	911.00
IUUC-Dno-028855	Dasypus novemcinctus	72.92	0.00e+00	1364.00
IUUC-Dor-030475	Dipodomys ordii	88.30	0.00e+00	722.00
IUUC-Dme-032088	Drosophila melanogaster	36.54	2.00e-110	394.00
IUUC-Eca-034147	Equus caballus	85.61	0.00e+00	1476.00
IUUC-Eeu-034703	Erinaceus europaeus	62.15	0.00e+00	753.00
IUUC-Fca-036550	Felis catus	74.70	0.00e+00	1257.00
IUUC-Gac-042087	Gasterosteus aculeatus	51.74	0.00e+00	897.00
IUUC-Ggo-045171	Gorilla gorilla	99.81	0.00e+00	1982.00
IUUC-Itr-048673	Ictidomys tridecemlineatus	75.14	0.00e+00	682.00
IUUC-Loc-052852	Lepisosteus oculatus	62.81	0.00e+00	928.00
IUUC-Laf-054033	Loxodonta africana	78.66	0.00e+00	1552.00
IUUC-Mcc-055431	Macaca mulatta	97.76	0.00e+00	1963.00
IUUC-Mmr-061035	Microcebus murinus	87.09	0.00e+00	1684.00
IUUC-Mdo-062172	Monodelphis domestica	66.71	0.00e+00	970.00
IUUC-Mmu-063966	Mus musculus	80.42	0.00e+00	1574.00
IUUC-Mpu-066307	Mustela putorius furo	78.75	0.00e+00	1424.00
IUUC-Nle-070172	Nomascus leucogenys	98.60	0.00e+00	1972.00
IUUC-Opr-070499	Ochotona princeps	74.61	0.00e+00	1402.00
IUUC-Ont-071920	Oreochromis niloticus	52.56	0.00e+00	946.00
IUUC-Ocu-074014	Oryctolagus cuniculus	83.82	0.00e+00	1217.00
IUUC-Ola-086360	Oryzias latipes	52.76	0.00e+00	944.00
IUUC-Oga-088202	Otolemur garnettii	84.10	0.00e+00	1696.00
IUUC-Oar-089819	Ovis aries	77.99	0.00e+00	1486.00
IUUC-Ptr-091076	Pan troglodytes	99.63	0.00e+00	1987.00
IUUC-Pan-092248	Papio anubis	98.06	0.00e+00	1946.00
IUUC-Pfo-096534	Poecilia formosa	60.15	0.00e+00	820.00
IUUC-Pab-098453	Pongo abelii	96.93	0.00e+00	1909.00
IUUC-Pca-100290	Procavia capensis	63.53	0.00e+00	728.00
IUUC-Pva-102317	Pteropus vampyrus	74.19	0.00e+00	1407.00
IUUC-Rno-104948	Rattus norvegicus	78.42	0.00e+00	1412.00
IUUC-Sha-106558	Sarcophilus harrisii	57.30	0.00e+00	1143.00
IUUC-Sar-113105	Sorex araneus	64.30	0.00e+00	1067.00
IUUC-Ssc-115312	Sus scrofa	80.37	0.00e+00	1565.00
IUUC-Tru-117995	Takifugu rubripes	62.95	0.00e+00	906.00
IUUC-Tsy-119325	Tarsius syrichta	77.98	0.00e+00	771.00
IUUC-Tni-120517	Tetraodon nigroviridis	57.85	0.00e+00	860.00
IUUC-Tbe-127439	Tupaia belangeri	71.90	6.00e-144	505.00
IUUC-Ttr-128829	Tursiops truncatus	73.06	0.00e+00	1396.00
IUUC-Vpa-130306	Vicugna pacos	81.86	0.00e+00	634.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence