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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046990
UUCD1 version UUC-HoS-00318
Ensembl Protein ID ENSP00000292431.3
UniProt Accession Q96RE7; NACC1_HUMAN
Genbank Protein ID AAK83885.1; AAH55396.1
Protein Name Nucleus accumbens-associated protein 1; BTB/POZ domain-containing protein 14B
Genbank Nucleotide ID AF395817; BC055396
Gene Name NACC1; BTBD14B; NAC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000160877.5 ENST00000292431.4 ENSP00000292431.3
ENSG00000160877.5 ENST00000585663.1 ENSP00000466017.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
miRecordsRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other BTB_Other 17699672
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.90e-17 64.0 30 93
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklden 68
           +Dv +vv+g  f+ah++vLaasSs+F++lf++    s+ +  ve+   vqp++f+++l+F+Ytg+l++n
   Q: 30   CDVSVVVKGHAFKAHRAVLAASSSYFRDLFNN----SR-SAVVELPAaVQPQSFQQILSFCYTGRLSMN 93
           8*****************************65....77.899****66******************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
 Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Protein Sequence
(Fasta)
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN 60
NSRSAVVELP AAVQPQSFQQ ILSFCYTGRL SMNVGDQFLL MYTAGFLQIQ EIMEKGTEFF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046990|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCAGGGGCA TAGAGAGGAG ACGGAGCCGG TTAGAAGGGG CGCGCTCGGA GCTCGGCTGG 60
CCTCGCCTGG AGGGCGGGGC CCGAGGGCGG TGCGCGGGCG GGGCCGGGGC CGCTCCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046990|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
Interpro

IPR018379--BEN_domain
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
PROSITE

PS51457--BEN
PS50097--BTB
Pfam

PF10523--BEN
PF00651--BTB
SMART

SM01025--BEN
SM00225--BTB
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:0051260--P:protein homooligomerization
GO:0006351--P:transcription, DNA-templated
KEGG hsa:112939
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001349 Ailuropoda melanoleuca 87.17 0.00e+00 881.00
IUUC-Aca-005131 Anolis carolinensis 80.37 0.00e+00 806.00
IUUC-Ame-011526 Astyanax mexicanus 68.68 0.00e+00 657.00
IUUC-Bta-012628 Bos taurus 89.10 0.00e+00 885.00
IUUC-Cja-018795 Callithrix jacchus 99.35 7.00e-90 324.00
IUUC-Cfa-021135 Canis familiaris 88.22 0.00e+00 886.00
IUUC-Cpo-022362 Cavia porcellus 82.35 0.00e+00 866.00
IUUC-Csa-023358 Chlorocebus sabaeus 99.24 0.00e+00 969.00
IUUC-Dre-028546 Danio rerio 67.74 0.00e+00 636.00
IUUC-Dno-029850 Dasypus novemcinctus 83.87 0.00e+00 828.00
IUUC-Dor-030712 Dipodomys ordii 90.27 0.00e+00 763.00
IUUC-Ete-032755 Echinops telfairi 81.01 1.00e-171 595.00
IUUC-Eca-034373 Equus caballus 91.92 0.00e+00 908.00
IUUC-Fca-035796 Felis catus 89.75 0.00e+00 892.00
IUUC-Gmo-038551 Gadus morhua 71.21 9.00e-92 330.00
IUUC-Ggo-045146 Gorilla gorilla 100.00 0.00e+00 976.00
IUUC-Hvu-047438 Hordeum vulgare 23.16 6.00e-05 42.70
IUUC-Itr-048458 Ictidomys tridecemlineatus 89.22 0.00e+00 924.00
IUUC-Lch-049952 Latimeria chalumnae 75.80 0.00e+00 785.00
IUUC-Laf-054517 Loxodonta africana 90.70 0.00e+00 924.00
IUUC-Mcc-055004 Macaca mulatta 91.48 0.00e+00 857.00
IUUC-Meu-056774 Macropus eugenii 87.10 0.00e+00 867.00
IUUC-Mmr-061098 Microcebus murinus 89.63 0.00e+00 930.00
IUUC-Mdo-062959 Monodelphis domestica 87.86 0.00e+00 880.00
IUUC-Mmu-064296 Mus musculus 86.42 0.00e+00 825.00
IUUC-Mpu-066424 Mustela putorius furo 95.52 2.00e-145 509.00
IUUC-Mlu-067831 Myotis lucifugus 88.14 0.00e+00 877.00
IUUC-Nle-069864 Nomascus leucogenys 95.26 0.00e+00 914.00
IUUC-Opr-070926 Ochotona princeps 83.86 5.00e-155 541.00
IUUC-Ont-071921 Oreochromis niloticus 72.87 2.00e-96 346.00
IUUC-Oan-073318 Ornithorhynchus anatinus 87.32 0.00e+00 631.00
IUUC-Ocu-074921 Oryctolagus cuniculus 62.26 1.00e-44 174.00
IUUC-Ola-086614 Oryzias latipes 70.61 7.00e-96 344.00
IUUC-Oga-088564 Otolemur garnettii 88.05 0.00e+00 845.00
IUUC-Oar-090443 Ovis aries 91.94 3.00e-142 498.00
IUUC-Ptr-090668 Pan troglodytes 100.00 0.00e+00 976.00
IUUC-Pan-092655 Papio anubis 99.43 0.00e+00 972.00
IUUC-Pfo-096632 Poecilia formosa 72.55 2.00e-96 347.00
IUUC-Pab-098490 Pongo abelii 100.00 0.00e+00 976.00
IUUC-Pca-100466 Procavia capensis 87.94 1.00e-133 469.00
IUUC-Pva-102597 Pteropus vampyrus 88.89 0.00e+00 899.00
IUUC-Rno-105179 Rattus norvegicus 86.23 0.00e+00 822.00
IUUC-Sha-107275 Sarcophilus harrisii 88.33 0.00e+00 816.00
IUUC-Sar-113571 Sorex araneus 83.51 7.00e-163 566.00
IUUC-Ssc-115494 Sus scrofa 88.39 0.00e+00 880.00
IUUC-Tru-118313 Takifugu rubripes 70.83 5.00e-97 348.00
IUUC-Tni-119786 Tetraodon nigroviridis 72.35 4.00e-99 355.00
IUUC-Ttr-128342 Tursiops truncatus 89.25 0.00e+00 917.00
IUUC-Vpa-130746 Vicugna pacos 77.93 4.00e-89 322.00
IUUC-Xtr-132831 Xenopus tropicalis 69.07 0.00e+00 630.00
Created Date 25-Jun-2017

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