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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064166
UUCD1 version UUC-MuM-01149
Ensembl Protein ID ENSMUSP00000075269.3
UniProt Accession Q69Z66; A2AJE3; B9EKJ6; Q3TPV7; Q8BRP5; Q8C4N1; MYSM1_MOUSE
Genbank Protein ID BAC31657.1; BAC38291.1; BAE37628.1; CAM14751.1; AAI50947.1; AAI51173.1; BAD32578.1
Protein Name Histone H2A deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1
Genbank Nucleotide ID AK043802; AK081684; AK164103; AL732611; BC150946; BC151172; AK173300
Gene Name Mysm1; Kiaa1915
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000062627.9 ENSMUST00000075872.3 ENSMUSP00000075269.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 79.14 0.00e+00 1241.00 IUUC-Hsa-046902
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
 Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
Protein Sequence
(Fasta)
MEAEEADVDV EGDVAAAAQP GNDESTASVF QDHYLDSTWR RENGCLPWTL DSTISDENRA 60
IIEKMLLEEE YYLSNKSLPG KFWVNQKEDN KKYTNSLQKS SKAMVDSPAK PASHSVKWTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064166|DUB,JAMM|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGATCTCGC GAGTACGCCT GCGTCAGGTG CAGTCATGGA GGCGGAGGAG GCGGATGTGG 60
ATGTGGAAGG AGATGTTGCG GCGGCTGCAC AGCCGGGGTG AGGCGCGGAG CGGGGTCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064166|DUB,JAMM|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR009057--Homeobox-like
IPR000555--JAMM/MPN+_dom
IPR017930--Myb_dom
IPR033497--MYSM1
IPR001005--SANT/Myb
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50934--SWIRM
Pfam

PF01398--JAB
PF00249--Myb_DNA-binding
PF04433--SWIRM
SMART

SM00232--JAB_MPN
SM00717--SANT
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0032403--F:protein complex binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0006338--P:chromatin remodeling
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0043473--P:pigmentation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030334--P:regulation of cell migration
GO:0051797--P:regulation of hair follicle development
GO:0006351--P:transcription, DNA-templated
KEGG mmu:320713
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001270 Ailuropoda melanoleuca 80.17 0.00e+00 1281.00
IUUC-Apl-003363 Anas platyrhynchos 70.09 0.00e+00 991.00
IUUC-Aca-005139 Anolis carolinensis 66.83 0.00e+00 1033.00
IUUC-Ame-011693 Astyanax mexicanus 54.01 0.00e+00 690.00
IUUC-Bta-013079 Bos taurus 78.94 0.00e+00 1220.00
IUUC-Cja-019242 Callithrix jacchus 78.07 0.00e+00 1212.00
IUUC-Cfa-020562 Canis familiaris 78.47 0.00e+00 1198.00
IUUC-Cpo-021656 Cavia porcellus 75.15 0.00e+00 1149.00
IUUC-Cre-022774 Chlamydomonas reinhardtii 30.22 1.00e-15 78.20
IUUC-Csa-023482 Chlorocebus sabaeus 78.65 0.00e+00 1220.00
IUUC-Cho-024724 Choloepus hoffmanni 74.23 5.00e-75 276.00
IUUC-Cme-027237 Cyanidioschyzon merolae 40.51 5.00e-30 125.00
IUUC-Dre-028234 Danio rerio 68.43 6.00e-172 597.00
IUUC-Dno-029985 Dasypus novemcinctus 73.95 0.00e+00 1045.00
IUUC-Dor-030957 Dipodomys ordii 71.77 0.00e+00 1041.00
IUUC-Ete-032831 Echinops telfairi 70.17 0.00e+00 1022.00
IUUC-Eca-033285 Equus caballus 77.70 0.00e+00 1211.00
IUUC-Eeu-035164 Erinaceus europaeus 65.25 0.00e+00 899.00
IUUC-Fca-036480 Felis catus 77.78 0.00e+00 1170.00
IUUC-Fal-037081 Ficedula albicollis 66.46 0.00e+00 947.00
IUUC-Gmo-039445 Gadus morhua 62.73 1.00e-161 563.00
IUUC-Gga-040639 Gallus gallus 69.82 0.00e+00 1027.00
IUUC-Gac-042370 Gasterosteus aculeatus 64.11 3.00e-153 535.00
IUUC-Ggo-044894 Gorilla gorilla 79.16 0.00e+00 1230.00
IUUC-Hsa-046902 Homo sapiens 79.04 0.00e+00 1228.00
IUUC-Itr-047908 Ictidomys tridecemlineatus 80.53 0.00e+00 1083.00
IUUC-Lch-049854 Latimeria chalumnae 57.60 0.00e+00 863.00
IUUC-Loc-052310 Lepisosteus oculatus 69.93 0.00e+00 634.00
IUUC-Laf-053369 Loxodonta africana 78.14 0.00e+00 1219.00
IUUC-Mcc-055385 Macaca mulatta 78.92 0.00e+00 1218.00
IUUC-Meu-056008 Macropus eugenii 60.17 0.00e+00 849.00
IUUC-Mga-059526 Meleagris gallopavo 65.65 0.00e+00 931.00
IUUC-Mmr-060949 Microcebus murinus 80.24 0.00e+00 1269.00
IUUC-Mdo-061821 Monodelphis domestica 71.58 0.00e+00 1112.00
IUUC-Mpu-065701 Mustela putorius furo 79.01 0.00e+00 1258.00
IUUC-Mlu-067089 Myotis lucifugus 78.76 0.00e+00 1248.00
IUUC-Nle-069917 Nomascus leucogenys 78.46 0.00e+00 1219.00
IUUC-Opr-070449 Ochotona princeps 70.07 0.00e+00 757.00
IUUC-Ont-071468 Oreochromis niloticus 65.64 1.00e-158 553.00
IUUC-Ocu-073867 Oryctolagus cuniculus 74.20 0.00e+00 679.00
IUUC-Ola-087430 Oryzias latipes 47.40 1.00e-171 597.00
IUUC-Olu-087581 Ostreococcus lucimarinus 35.83 1.00e-30 127.00
IUUC-Oga-088967 Otolemur garnettii 78.43 0.00e+00 1196.00
IUUC-Oar-089773 Ovis aries 78.70 0.00e+00 1215.00
IUUC-Ptr-091260 Pan troglodytes 79.04 0.00e+00 1229.00
IUUC-Pan-092564 Papio anubis 78.67 0.00e+00 1213.00
IUUC-Psi-094097 Pelodiscus sinensis 70.56 0.00e+00 944.00
IUUC-Pma-094538 Petromyzon marinus 66.33 1.00e-37 150.00
IUUC-Pfo-097392 Poecilia formosa 49.02 0.00e+00 696.00
IUUC-Pab-098496 Pongo abelii 78.22 0.00e+00 1212.00
IUUC-Pca-100438 Procavia capensis 61.42 1.00e-104 374.00
IUUC-Pva-103082 Pteropus vampyrus 78.97 0.00e+00 1240.00
IUUC-Rno-105976 Rattus norvegicus 89.79 0.00e+00 1394.00
IUUC-Sha-106498 Sarcophilus harrisii 67.08 0.00e+00 990.00
IUUC-Sar-113274 Sorex araneus 71.76 0.00e+00 1062.00
IUUC-Sre-115088 Sporisorium reilianum 34.09 1.00e-08 56.20
IUUC-Ssc-115653 Sus scrofa 77.60 0.00e+00 1218.00
IUUC-Tgu-117140 Taeniopygia guttata 66.46 0.00e+00 959.00
IUUC-Tru-117818 Takifugu rubripes 64.07 4.00e-151 528.00
IUUC-Tsy-118897 Tarsius syrichta 75.06 0.00e+00 1121.00
IUUC-Tni-119769 Tetraodon nigroviridis 50.51 0.00e+00 676.00
IUUC-Tbe-127944 Tupaia belangeri 88.24 0.00e+00 755.00
IUUC-Ttr-129252 Tursiops truncatus 89.88 0.00e+00 738.00
IUUC-Vpa-130289 Vicugna pacos 78.60 0.00e+00 1162.00
IUUC-Xtr-131964 Xenopus tropicalis 56.44 0.00e+00 822.00
Created Date 25-Jun-2017

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