iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-51	174.6	317	1037

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 3    lkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp........................................................ 42
           l N+gN+CY+NSv+ +L + p + ++l++   ++ln  ++                                                        
   Q: 317  LCNIGNSCYLNSVVYTLRFAPHFLHNLHH-LIQDLNVVQQtivrqqtarsaslgknvsaaqleharswsskdlatstdqysgqnggvnsgnggsgs 411
           66***************************.4444444444455566678888999999***********************************999 PP
   S: 43   .kepkgellkslqklfeelw....kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk........................ 109
            k+++++++++l++l ++l      ++++ +   +ll+a+++++  f+g++qqDa+Efl+++l+ ++e+ ++                        
   Q: 412  sKSTHQSVTEKLHELYNNLHgnemADSTEPYHADTLLHAIQDVNATFEGNQQQDAHEFLMCVLNCIRETNQSlikaigecpeviangyianpdevd 507
           999999*************887779999999999**********************************9977888888888887777654433322 PP
   S: 110  .....eknkpkeeeeeedkselsde....................................................................... 129
                                                                                                           
   Q: 508  tgegqD------------------Rtdstasqnlnagngslatsqttttktsffsrkskrkdevkpskstrvqsplkensptaggitgagtahata 585
           222220..................133344466778888888888888888888888888889********************************* PP
   S: 130  .............................................................aeekkkkknkslisdlFqgqlksqikclecdnvss 164
                                                                         ee+  + n ++ s  F+g +  ++kcl+c++++ 
   Q: 586  nslfylntvdlsgasstsgsastsasgvvstsaalptppqatkyssddemnsatvlkdkmrLEERIRELNLNFFSSDFEGIVVLTTKCLSCETITR 681
           *****************************************************999998887788888888************************* PP
   S: 165  reepfldlslpvp....gkeetkkeslqd....cL.esftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekink 251
           +++ +ld+s+pvp    +     + +lqd     + +s  ++e ++genky+c++c++++ea ++++ + lP+ L+++L+Rf      +  ek+++
   Q: 682  QKQGMLDISVPVPisgyD-----NADLQDkpstYIqNSCITKEYFRGENKYSCNQCTGYTEAIRSISYEVLPRLLVIQLNRF-----SGGMEKVST 767
           *************55432.....3344431111444888999****************************************.....345679999 PP
   S: 252  kvefpleLdlspfcts..peekqkekkkYeLiavvvHsG.slssGHYvayvkn........................................... 301
           +v +   ++l  fc++  +  + ++ + Y+L++v+ H G +l  GHY+ay                                              
   Q: 768  YVPTT--FTLPCFCATccELGEGNKLHVYKLYSVITHVGaTLTVGHYIAYTCFldlasdyvncpkdrrntmtnsqtmasqavpsnenaapnngsss 861
           98665..6666555553322334459************************99889***************************************** PP
   S: 302  ................................................................................................ 301
                                                                                                           
   Q: 862  vastpviaaasalassgnilmkkmkfgrskasssgdmsknvkqvngiisknitngigklsisttcqgvnccamrlcctqqtsssnstscsdfsees 957
           ************************************************************************************************ PP
   S: 302  ..................................ekgk....WllfdDskVtevkeeevleetg......staYvlfYkr 337
                                              +g+    W+ +dD+k++++++ e++e  +       t+Y+lfY r
   Q: 958  lqngsnsnlsfggsgstyptgygstgrggvranyAHGGpdpiWYMCDDDKIKAMTQREFEELLSptrkitITPYLLFYAR 1037
           *******99999999999999999988888877633336788**************99999777999**99*******86 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MHEYDVNERK EEPASLPPTQ NETTEINSQL RQDQQNQEQE NPLRQQDNSH PPQENPINQQ 60
EKDTLQVSVL YPLVVCAQLA DSQLVLTADT PKLSPVKKRQ RRVYVADTLR CYSLRSRQEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCGATTAT TTCTCTTGCA TCCCTAGTCG TCCGCTCCAA TATAATAATT TCACTAGGCA 60
ACCTTAATGT AATAAGCGAC GTAAAACCGG GACTAAATAG CTCCAGAGCG AATGCTTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG15817

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	28.77	3.00e-18	86.30
IUUC-Apl-004204	Anas platyrhynchos	29.38	8.00e-19	88.20
IUUC-Aca-004637	Anolis carolinensis	31.11	2.00e-19	90.10
IUUC-Ame-011718	Astyanax mexicanus	30.48	9.00e-20	91.70
IUUC-Bta-012552	Bos taurus	29.19	8.00e-19	88.20
IUUC-Cja-019588	Callithrix jacchus	28.77	2.00e-18	87.40
IUUC-Cfa-020211	Canis familiaris	28.77	2.00e-18	87.00
IUUC-Cpo-021551	Cavia porcellus	28.30	2.00e-18	87.40
IUUC-Csa-024186	Chlorocebus sabaeus	28.77	2.00e-18	87.00
IUUC-Dre-028184	Danio rerio	29.11	4.00e-17	82.40
IUUC-Dno-029669	Dasypus novemcinctus	27.23	1.00e-18	88.20
IUUC-Dor-030168	Dipodomys ordii	28.49	3.00e-14	73.20
IUUC-Ete-032825	Echinops telfairi	28.12	6.00e-20	92.00
IUUC-Eca-033595	Equus caballus	29.25	3.00e-19	89.40
IUUC-Fal-037592	Ficedula albicollis	28.91	1.00e-16	81.30
IUUC-Gmo-039680	Gadus morhua	32.80	3.00e-22	99.40
IUUC-Gga-041196	Gallus gallus	29.38	1.00e-18	87.40
IUUC-Gac-042292	Gasterosteus aculeatus	32.78	3.00e-22	99.40
IUUC-Ggo-044671	Gorilla gorilla	28.77	1.00e-18	87.40
IUUC-Hsa-047020	Homo sapiens	28.77	1.00e-18	87.40
IUUC-Itr-048800	Ictidomys tridecemlineatus	29.25	9.00e-19	88.20
IUUC-Lch-050543	Latimeria chalumnae	31.79	4.00e-20	92.40
IUUC-Loc-052338	Lepisosteus oculatus	30.00	9.00e-18	84.70
IUUC-Laf-053707	Loxodonta africana	27.88	6.00e-19	89.00
IUUC-Mcc-055885	Macaca mulatta	28.77	2.00e-18	87.40
IUUC-Mga-059346	Meleagris gallopavo	29.38	2.00e-18	87.00
IUUC-Mmr-061612	Microcebus murinus	29.25	8.00e-19	88.20
IUUC-Mdo-062887	Monodelphis domestica	30.39	2.00e-17	84.00
IUUC-Mmu-064044	Mus musculus	30.39	3.00e-18	86.30
IUUC-Mpu-066847	Mustela putorius furo	28.77	3.00e-18	86.30
IUUC-Mlu-067684	Myotis lucifugus	29.25	1.00e-18	87.80
IUUC-Nle-070057	Nomascus leucogenys	28.77	1.00e-18	87.40
IUUC-Opr-070463	Ochotona princeps	28.77	7.00e-18	85.10
IUUC-Ont-071975	Oreochromis niloticus	33.16	1.00e-22	101.00
IUUC-Ocu-074840	Oryctolagus cuniculus	28.30	5.00e-18	85.50
IUUC-Ola-087088	Oryzias latipes	30.20	2.00e-21	97.10
IUUC-Oga-088472	Otolemur garnettii	28.77	1.00e-18	87.80
IUUC-Oar-089498	Ovis aries	29.19	5.00e-19	89.00
IUUC-Ptr-091395	Pan troglodytes	28.77	1.00e-18	87.40
IUUC-Pan-092462	Papio anubis	28.77	2.00e-18	87.40
IUUC-Pfo-096314	Poecilia formosa	29.52	6.00e-22	98.60
IUUC-Pab-098568	Pongo abelii	28.77	1.00e-18	87.40
IUUC-Pva-102853	Pteropus vampyrus	28.77	9.00e-19	88.20
IUUC-Rno-105573	Rattus norvegicus	28.77	1.00e-18	87.40
IUUC-Sha-107495	Sarcophilus harrisii	29.25	6.00e-20	91.70
IUUC-Sar-113545	Sorex araneus	28.77	4.00e-18	86.30
IUUC-Ssc-115962	Sus scrofa	28.77	8.00e-19	88.20
IUUC-Tgu-116731	Taeniopygia guttata	28.91	9.00e-17	81.30
IUUC-Tru-117893	Takifugu rubripes	30.77	6.00e-17	82.00
IUUC-Tni-119819	Tetraodon nigroviridis	32.84	3.00e-23	103.00
IUUC-Ttr-128404	Tursiops truncatus	28.77	1.00e-18	87.40
IUUC-Vpa-130205	Vicugna pacos	28.77	5.00e-19	89.00
IUUC-Xtr-132613	Xenopus tropicalis	31.78	6.00e-22	98.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence