iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21389083

Classification

Family	E-value	Score	Start	End
DUB/USP	3.50e-87	294.4	81	784

Active Site

Position(s)	Description	Evidence
90	Nucleophile	{ECO:0000269\|PubMed:15694335, ECO:0000269\|PubMed:16531995, ECO:0000269\|PubMed:26388029}
593	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w.....ksk 64
           +Gl+NlgNtCY+NS+LQ+L+++p +++ +++      +kke+l++e+++++kg          el++slq+l+ ++       +     +++
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHlfniisRKKEALKDEANQKDKGnckedslasyELICSLQSLIISVeqlqasfLlnpekYTD 172
           6************************************999999999999999999999*****99999999999995555555144555888 PP
   S: 65   kkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsde.......... 129
           + a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++                  e  +pkee+++ +++e++++          
   Q: 173  ELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLlkkeevknvaelptkveEIPHPKEEMNGINSIEMDSMrhsedfkekl 264
           88*****************************************556677888999999998888899999999999999998********** PP
   S: 130  ............................................................................................ 129
                                                                                                       
   Q: 265  pkgngkrksdtefgnmkkkvklskehqsleenqrqtrskrkatsdtlesppkiipkyisenesprpsqkksrvkinwlksatkqpsilskfc 356
           ******************************************************************************************** PP
   S: 130  ....................................................aeekkkkknk.....slisdlFqgqlksqikclecdnvss 164
                                                               +e k+ +k++     +l+++lFqgql  +++clec++ ++
   Q: 357  slgkittnqgvkgqskenecdpeedlgkcesdnttngcglespgntvtpvnvNEVKPINKGEeqigfELVEKLFQGQLVLRTRCLECESLTE 448
           **************************************************99555555555556666************************* PP
   S: 165  reepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRf..... 237
           r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c++++eae++l ++k+Pev+++hLk+f     
   Q: 449  RREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFaasgl 540
           ****************99998*********************************************************************** PP
   S: 238  sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn........................... 301
           +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a vk                            
   Q: 541  EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTASVKVtdlnsleldkgnfvvdqmceigkpepl 627
           ******************************99.....678**************************************************** PP
   S: 302  ............................................................................................ 301
                                                                                                       
   Q: 628  neeeargvvenyndeevsirvggntqpskvlnkknveaigllggqkskadyelynkasnpdkvastafaenrnsetsdttgthesdrnkess 719
           ********************************************************************************999999999999 PP
   S: 302  .......................ekgkWllfdDskVtevkeeevleetg......staYvlfYkr 337
                                   +gkWllfdDs+V++++e+++l++ +      st+Y+lfYk+
   Q: 720  dqtginisgfenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstsptSTPYLLFYKK 784
           999999999988888888877766999*******************888**************97 PP

Organism

Homo sapiens

Functional Description
(View)

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).

Protein Sequence
(Fasta)

MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQENEEKAS EYRASEIDQV 60
VPAAQSSPIN CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKSGVK HLFNIISRKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGGCGGG GCTTACCGCG AGGGCCTCGC TCCGGAAGCC GCACCCTCCG CGGCGTCCCA 60
CCGTCGAGGA TTAACAAAAC GCCAAACAAG ATTTTAACAG TCGGCAGCGA AAGCGCGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0036297--P:interstrand cross-link repair
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7398

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	94.40	0.00e+00	1432.00
IUUC-Apl-004204	Anas platyrhynchos	73.01	0.00e+00	939.00
IUUC-Aca-004637	Anolis carolinensis	66.46	0.00e+00	935.00
IUUC-Ame-011718	Astyanax mexicanus	48.08	5.00e-173	601.00
IUUC-Bta-012552	Bos taurus	91.85	0.00e+00	1403.00
IUUC-Cja-019588	Callithrix jacchus	96.94	0.00e+00	1514.00
IUUC-Cfa-020211	Canis familiaris	94.39	0.00e+00	1440.00
IUUC-Cpo-021551	Cavia porcellus	84.08	0.00e+00	1265.00
IUUC-Csa-024186	Chlorocebus sabaeus	97.45	0.00e+00	1527.00
IUUC-Cho-024739	Choloepus hoffmanni	82.97	0.00e+00	749.00
IUUC-Dre-028184	Danio rerio	49.27	2.00e-176	612.00
IUUC-Dno-029669	Dasypus novemcinctus	90.36	0.00e+00	1395.00
IUUC-Dor-030168	Dipodomys ordii	86.93	0.00e+00	1260.00
IUUC-Dme-031732	Drosophila melanogaster	28.77	5.00e-18	87.00
IUUC-Ete-032825	Echinops telfairi	86.46	0.00e+00	952.00
IUUC-Eca-033595	Equus caballus	93.68	0.00e+00	1352.00
IUUC-Eeu-034877	Erinaceus europaeus	79.94	1.00e-160	560.00
IUUC-Fca-035381	Felis catus	93.72	0.00e+00	1011.00
IUUC-Fal-037592	Ficedula albicollis	69.38	0.00e+00	965.00
IUUC-Gmo-039680	Gadus morhua	44.32	5.00e-152	531.00
IUUC-Gga-041196	Gallus gallus	72.12	0.00e+00	1058.00
IUUC-Gac-042292	Gasterosteus aculeatus	57.25	1.00e-82	301.00
IUUC-Ggo-044671	Gorilla gorilla	99.24	0.00e+00	1560.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	85.11	0.00e+00	1265.00
IUUC-Lch-050543	Latimeria chalumnae	57.22	0.00e+00	705.00
IUUC-Loc-052338	Lepisosteus oculatus	53.25	0.00e+00	704.00
IUUC-Laf-053707	Loxodonta africana	90.75	0.00e+00	1412.00
IUUC-Mcc-055885	Macaca mulatta	97.45	0.00e+00	1528.00
IUUC-Meu-056573	Macropus eugenii	67.34	0.00e+00	952.00
IUUC-Mga-059346	Meleagris gallopavo	72.73	0.00e+00	1006.00
IUUC-Mmr-061612	Microcebus murinus	93.50	0.00e+00	1404.00
IUUC-Mdo-062887	Monodelphis domestica	73.85	0.00e+00	1058.00
IUUC-Mmu-064044	Mus musculus	88.42	0.00e+00	1367.00
IUUC-Mpu-066847	Mustela putorius furo	94.78	0.00e+00	1444.00
IUUC-Mlu-067684	Myotis lucifugus	91.49	0.00e+00	1423.00
IUUC-Nle-070057	Nomascus leucogenys	98.34	0.00e+00	1548.00
IUUC-Opr-070463	Ochotona princeps	84.06	0.00e+00	1256.00
IUUC-Ont-071975	Oreochromis niloticus	51.50	5.00e-143	501.00
IUUC-Oan-073062	Ornithorhynchus anatinus	85.71	1.00e-46	178.00
IUUC-Ocu-074840	Oryctolagus cuniculus	93.12	0.00e+00	1432.00
IUUC-Ola-087088	Oryzias latipes	46.75	4.00e-173	601.00
IUUC-Oga-088472	Otolemur garnettii	92.99	0.00e+00	1428.00
IUUC-Oar-089498	Ovis aries	92.10	0.00e+00	1409.00
IUUC-Ptr-091395	Pan troglodytes	99.62	0.00e+00	1566.00
IUUC-Pan-092462	Papio anubis	97.58	0.00e+00	1528.00
IUUC-Psi-093583	Pelodiscus sinensis	71.94	0.00e+00	911.00
IUUC-Pma-094644	Petromyzon marinus	36.78	1.00e-28	119.00
IUUC-Pfo-096314	Poecilia formosa	46.69	5.00e-169	588.00
IUUC-Pab-098568	Pongo abelii	98.98	0.00e+00	1556.00
IUUC-Pca-100948	Procavia capensis	81.58	0.00e+00	1239.00
IUUC-Pva-102853	Pteropus vampyrus	93.37	0.00e+00	1436.00
IUUC-Rno-105573	Rattus norvegicus	88.66	0.00e+00	1353.00
IUUC-Sha-107495	Sarcophilus harrisii	72.47	0.00e+00	892.00
IUUC-Sar-113545	Sorex araneus	77.68	0.00e+00	1110.00
IUUC-Ssc-115962	Sus scrofa	93.79	0.00e+00	1456.00
IUUC-Tgu-116731	Taeniopygia guttata	69.69	0.00e+00	980.00
IUUC-Tru-117893	Takifugu rubripes	46.14	1.00e-158	553.00
IUUC-Tsy-119644	Tarsius syrichta	84.44	0.00e+00	1256.00
IUUC-Tni-119819	Tetraodon nigroviridis	45.21	1.00e-168	586.00
IUUC-Tbe-127272	Tupaia belangeri	88.48	0.00e+00	1256.00
IUUC-Ttr-128404	Tursiops truncatus	93.49	0.00e+00	1447.00
IUUC-Vpa-130205	Vicugna pacos	92.86	0.00e+00	1434.00
IUUC-Xtr-132613	Xenopus tropicalis	56.25	0.00e+00	747.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence