iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000007890.6	ENSRNOT00000010933.6	ENSRNOP00000010935.4
ENSRNOG00000007890.6	ENSRNOT00000084640.1	ENSRNOP00000069155.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-88	298.2	81	783

Active Site

Position(s)	Description	Evidence
90	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
593	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkg..........ellkslqklfeel.......w..... 61
           +Gl+NlgNtCY+NS+LQ+L+++p ++  +++      +kke+l++++ +++kg          el++slq+l+ ++       +     
   Q: 81   VGLNNLGNTCYLNSILQVLYFCPGFKAGVKHlfniisRKKEALKDDSIQKDKGsckedplasyELICSLQSLIISVeqlqasfLlnpek 169
           6******************************999*999999999998888888999999999999999999999995555555144555 PP
   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..................... 129
           ++++ a++pr+ll++l++++++++gy q+DaqE+l+++l +++e+++  k++++++++e ++ + +++                     
   Q: 170  YTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEIKNLTEFSS-KVEEKslqkeetggisstetdstrnl 257
           88888*****************************************5533333333322221.11111345568899999999999*** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 258  ddlkeqlpkgnwkrksdgesgnmkkkvklsresqpleenqrqtrskrkatgdtleaspkiipkcvsenesakpsqkkskvkinwlkpat 346
           ***************************************************************************************** PP
   S: 130  ...................................................................aeekkkkknk.....slisdlF 146
                                                                               ++            +l+++lF
   Q: 347  kqpsilskfcslgkittnqrskgqpkvnegdleedlekdgrdntvngsgpaspgssvtpvdsseaksINKG-----AeqigfELVEKLF 430
           ***********************************************************988544333333.....246666******* PP
   S: 147  qgqlksqikclecdnvssreepfldlslpvpgkeetkke..............slqdcLesftkeeelegenkyycekckkkqeaekkl 221
           qgql  +++clec++ ++r+e+f+d+s+pv+++e +k e              +l++++++f++ e++ ge+ky+ce+c++++eae++l
   Q: 431  QGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEesseispepktemkTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSL 519
           **********************************99998************************************************** PP
   S: 222  klkklPevLilhLkRf.....sfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn... 301
            ++k+Pev+++hLk+f     +f+++++  +kin+ + +pl+L+l+++ t+p+     +++Y L+avv+HsG ++ssGHY+a vk    
   Q: 520  LFDKMPEVITIHLKCFaasglEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPT-----NDSYGLFAVVMHSGiTISSGHYTASVKVtdl 603
           ***************************************************99.....678**************************** PP
   S: 302  ......................................................................................... 301
                                                                                                    
   Q: 604  nsleldkgnfvvdqmceigkpeplneeeargtaenyddevsirvggnaqpskvlnkknvegigllggqkskadyelcskasnpekvvgt 692
           ***************************************************************************************** PP
   S: 302  .................................................ekgkWllfdDskVtevkeeevleetg......staYvlfY 335
                                                             +gkWllfdDs+V++++e+++l++ +      st+Y+lfY
   Q: 693  pftdsrnsetndtngtqesdrskessdqtginvsglenkisyvvqslkeYEGKWLLFDDSEVKVTEEKDFLNSLSpstsptSTPYLLFY 781
           *************9999999999999999999999988888888877766999*******************888************** PP
   S: 336  kr 337
           k+
   Q: 782  KK 783
           97 PP

Organism

Rattus norvegicus

Functional Description
(View)

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.

Protein Sequence
(Fasta)

MPGVIPSESN GLSRGSPSKK NRLSLKFFQK KETKRALDFT DSQEDEEKAS EYRGSEIDQV 60
VPAAQSSPVS CEKRENLLPF VGLNNLGNTC YLNSILQVLY FCPGFKAGVK HLFNIISRKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCACTTTC CGTGGACGCC ACCTCCAGCC GCGACGCTGG CGCGGGCGGG GGTTCACTCG 60
CGGGGGTCCT GAGACTGAGG AAAACGCGCC AAGTTCCCCT CGGCAGCTGA GCGGGGACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0068--Autocatalytic cleavage
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR033815--USP1
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006281--P:DNA repair
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0016579--P:protein deubiquitination
GO:0006282--P:regulation of DNA repair
GO:0009411--P:response to UV
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:313387

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001939	Ailuropoda melanoleuca	88.17	0.00e+00	1329.00
IUUC-Apl-004204	Anas platyrhynchos	72.60	0.00e+00	935.00
IUUC-Aca-004637	Anolis carolinensis	65.74	0.00e+00	919.00
IUUC-Ame-011718	Astyanax mexicanus	48.74	2.00e-169	589.00
IUUC-Bta-012552	Bos taurus	86.11	0.00e+00	1316.00
IUUC-Cja-019588	Callithrix jacchus	88.03	0.00e+00	1360.00
IUUC-Cfa-020211	Canis familiaris	89.17	0.00e+00	1353.00
IUUC-Cpo-021551	Cavia porcellus	80.48	0.00e+00	1221.00
IUUC-Csa-024186	Chlorocebus sabaeus	88.66	0.00e+00	1375.00
IUUC-Cho-024739	Choloepus hoffmanni	75.86	0.00e+00	675.00
IUUC-Dre-028184	Danio rerio	48.90	3.00e-171	595.00
IUUC-Dno-029669	Dasypus novemcinctus	84.50	0.00e+00	1304.00
IUUC-Dor-030168	Dipodomys ordii	82.21	0.00e+00	1196.00
IUUC-Dme-031732	Drosophila melanogaster	28.77	4.00e-18	87.00
IUUC-Ete-032825	Echinops telfairi	81.42	0.00e+00	882.00
IUUC-Eca-033595	Equus caballus	86.26	0.00e+00	1234.00
IUUC-Eeu-034877	Erinaceus europaeus	74.09	6.00e-146	511.00
IUUC-Fca-035381	Felis catus	86.88	0.00e+00	935.00
IUUC-Fal-037592	Ficedula albicollis	69.47	0.00e+00	974.00
IUUC-Gmo-039680	Gadus morhua	44.74	4.00e-150	525.00
IUUC-Gga-041196	Gallus gallus	72.56	0.00e+00	1066.00
IUUC-Gac-042292	Gasterosteus aculeatus	50.08	6.00e-142	498.00
IUUC-Ggo-044671	Gorilla gorilla	88.66	0.00e+00	1370.00
IUUC-Hsa-047020	Homo sapiens	88.66	0.00e+00	1371.00
IUUC-Itr-048800	Ictidomys tridecemlineatus	80.41	0.00e+00	1190.00
IUUC-Lch-050543	Latimeria chalumnae	56.90	0.00e+00	692.00
IUUC-Loc-052338	Lepisosteus oculatus	52.89	0.00e+00	698.00
IUUC-Laf-053707	Loxodonta africana	85.55	0.00e+00	1317.00
IUUC-Mcc-055885	Macaca mulatta	88.66	0.00e+00	1379.00
IUUC-Meu-056573	Macropus eugenii	68.35	0.00e+00	970.00
IUUC-Mga-059346	Meleagris gallopavo	72.33	0.00e+00	1011.00
IUUC-Mmr-061612	Microcebus murinus	87.77	0.00e+00	1306.00
IUUC-Mdo-062887	Monodelphis domestica	73.20	0.00e+00	1053.00
IUUC-Mmu-064044	Mus musculus	93.76	0.00e+00	1460.00
IUUC-Mpu-066847	Mustela putorius furo	88.41	0.00e+00	1338.00
IUUC-Mlu-067684	Myotis lucifugus	86.26	0.00e+00	1333.00
IUUC-Nle-070057	Nomascus leucogenys	88.54	0.00e+00	1371.00
IUUC-Opr-070463	Ochotona princeps	79.82	0.00e+00	1186.00
IUUC-Ont-071975	Oreochromis niloticus	51.02	1.00e-141	497.00
IUUC-Oan-073062	Ornithorhynchus anatinus	86.73	3.00e-47	180.00
IUUC-Ocu-074840	Oryctolagus cuniculus	87.77	0.00e+00	1334.00
IUUC-Ola-087088	Oryzias latipes	46.82	4.00e-172	598.00
IUUC-Oga-088472	Otolemur garnettii	87.52	0.00e+00	1332.00
IUUC-Oar-089498	Ovis aries	86.11	0.00e+00	1315.00
IUUC-Ptr-091395	Pan troglodytes	88.54	0.00e+00	1368.00
IUUC-Pan-092462	Papio anubis	88.79	0.00e+00	1379.00
IUUC-Psi-093583	Pelodiscus sinensis	71.28	0.00e+00	886.00
IUUC-Pma-094644	Petromyzon marinus	36.36	3.00e-28	118.00
IUUC-Pfo-096314	Poecilia formosa	46.75	6.00e-167	581.00
IUUC-Pab-098568	Pongo abelii	88.79	0.00e+00	1377.00
IUUC-Pca-100948	Procavia capensis	77.10	0.00e+00	1165.00
IUUC-Pva-102853	Pteropus vampyrus	86.86	0.00e+00	1325.00
IUUC-Sha-107495	Sarcophilus harrisii	72.60	0.00e+00	909.00
IUUC-Sar-113545	Sorex araneus	72.70	0.00e+00	1028.00
IUUC-Ssc-115962	Sus scrofa	86.82	0.00e+00	1333.00
IUUC-Tgu-116731	Taeniopygia guttata	70.42	0.00e+00	991.00
IUUC-Tru-117893	Takifugu rubripes	46.54	7.00e-158	551.00
IUUC-Tsy-119644	Tarsius syrichta	78.93	0.00e+00	1161.00
IUUC-Tni-119819	Tetraodon nigroviridis	45.33	4.00e-169	588.00
IUUC-Tbe-127272	Tupaia belangeri	82.17	0.00e+00	1156.00
IUUC-Ttr-128404	Tursiops truncatus	87.76	0.00e+00	1343.00
IUUC-Vpa-130205	Vicugna pacos	86.13	0.00e+00	1318.00
IUUC-Xtr-132613	Xenopus tropicalis	55.11	0.00e+00	736.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence