iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.00e-06	28.1	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C++Cl+ +++ p++++CgH f++ C+  +   +   + +   CP Cr
   Q: 16   CPVCLDFLQE-PVSVDCGHSFCLRCISEFcEKSDGAQGGVYACPQCR 61
           ********99.***************9995444555666779****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

Protein Sequence
(Fasta)

MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC 60
RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGACGGT GCGGGCGGCC GGGAGCGCAG CCCTCCGGGA GGCGGGTCAT GGCCTGGGCG 60
CCGCCCGGGG AGCGGCTGCG CGAGGATGCG CGGTGCCCGG TGTGCCTGGA TTTCCTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

hsa:25893

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001785	Ailuropoda melanoleuca	73.96	0.00e+00	676.00
IUUC-Aca-004891	Anolis carolinensis	43.62	2.00e-97	349.00
IUUC-Bta-012726	Bos taurus	82.53	0.00e+00	724.00
IUUC-Cja-018951	Callithrix jacchus	86.33	0.00e+00	759.00
IUUC-Cfa-021114	Canis familiaris	81.31	0.00e+00	773.00
IUUC-Cpo-021630	Cavia porcellus	66.38	1.00e-163	569.00
IUUC-Cho-024849	Choloepus hoffmanni	79.73	2.00e-114	405.00
IUUC-Dno-029530	Dasypus novemcinctus	80.51	0.00e+00	711.00
IUUC-Eeu-035044	Erinaceus europaeus	80.93	2.00e-111	396.00
IUUC-Fca-035988	Felis catus	80.04	0.00e+00	756.00
IUUC-Laf-054172	Loxodonta africana	82.14	0.00e+00	773.00
IUUC-Mdo-062418	Monodelphis domestica	62.85	5.00e-174	603.00
IUUC-Mmu-063326	Mus musculus	79.58	0.00e+00	723.00
IUUC-Mpu-066338	Mustela putorius furo	78.56	0.00e+00	708.00
IUUC-Mlu-067864	Myotis lucifugus	70.40	3.00e-176	611.00
IUUC-Nle-069883	Nomascus leucogenys	94.86	0.00e+00	904.00
IUUC-Opr-070347	Ochotona princeps	67.03	5.00e-159	553.00
IUUC-Oan-073120	Ornithorhynchus anatinus	52.56	7.00e-117	414.00
IUUC-Ocu-074489	Oryctolagus cuniculus	73.27	2.00e-113	402.00
IUUC-Oga-087926	Otolemur garnettii	80.04	0.00e+00	766.00
IUUC-Oar-090340	Ovis aries	82.06	0.00e+00	739.00
IUUC-Ptr-091292	Pan troglodytes	96.91	0.00e+00	860.00
IUUC-Pan-092710	Papio anubis	94.44	0.00e+00	811.00
IUUC-Pab-098011	Pongo abelii	96.50	0.00e+00	862.00
IUUC-Pca-100277	Procavia capensis	80.59	2.00e-113	402.00
IUUC-Pva-103101	Pteropus vampyrus	82.47	0.00e+00	785.00
IUUC-Rno-105618	Rattus norvegicus	79.79	0.00e+00	728.00
IUUC-Sha-106630	Sarcophilus harrisii	60.13	3.00e-160	558.00
IUUC-Ssc-116382	Sus scrofa	81.46	0.00e+00	737.00
IUUC-Tsy-119220	Tarsius syrichta	74.28	4.00e-176	610.00
IUUC-Ttr-129036	Tursiops truncatus	81.44	0.00e+00	731.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence