iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000048234.13	ENSMUST00000062525.10	ENSMUSP00000050388.5
ENSMUSG00000048234.13	ENSMUST00000195136.1	ENSMUSP00000141667.1
ENSMUSG00000048234.13	ENSMUST00000195705.1	ENSMUSP00000141233.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.90e-06	29.4	265	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e f  kd  ++lpC+H+fh+ C+  w         + +CP C+
   Q: 265  CAVCIENFkvKDVIRILPCKHIFHRICIDPW------LLDHRTCPMCK 306
           ********9988899****************......9999******6 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.

Protein Sequence
(Fasta)

MAARRRPAAG VGARDALAVL ALALCTPGVG GGALEWYSAM VSIEYVDPQS NLTVWSVSES 60
GRFGESSLRE ERQGLVGVPR APAPAEGCAP DTRFVAPGAL GNAPWVALVA RGGCTFKDKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTCCGCCC CCGCCGCGCT CGGCGGTCTC TCGCGAGCCG CCGCCGTCTC CTCAAAGCTG 60
TGGGCCAGCC TGGAGTGAGT CGCCTCGTTC TGACTCGCGC TCTTCTTCCT CAGTAGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035690--P:cellular response to drug
GO:0043409--P:negative regulation of MAPK cascade
GO:0031647--P:regulation of protein stability

KEGG

mmu:67702

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001968	Ailuropoda melanoleuca	77.99	1.00e-160	559.00
IUUC-Apl-004109	Anas platyrhynchos	70.61	7.00e-100	356.00
IUUC-Bta-012340	Bos taurus	75.00	6.00e-154	536.00
IUUC-Cja-019566	Callithrix jacchus	75.27	1.00e-159	555.00
IUUC-Cfa-020289	Canis familiaris	80.17	1.00e-107	382.00
IUUC-Cpo-021916	Cavia porcellus	66.03	9.00e-76	276.00
IUUC-Csa-024084	Chlorocebus sabaeus	76.92	6.00e-157	546.00
IUUC-Cho-024305	Choloepus hoffmanni	77.35	9.00e-124	436.00
IUUC-Cgl-026578	Colletotrichum gloeosporioides	48.08	3.00e-12	66.20
IUUC-Dno-030098	Dasypus novemcinctus	76.83	2.00e-165	575.00
IUUC-Dor-030620	Dipodomys ordii	74.54	1.00e-144	506.00
IUUC-Ete-032306	Echinops telfairi	78.06	3.00e-157	548.00
IUUC-Fca-035950	Felis catus	79.75	5.00e-111	393.00
IUUC-Fal-037429	Ficedula albicollis	65.94	7.00e-131	460.00
IUUC-Fox-038011	Fusarium oxysporum	41.10	2.00e-13	70.50
IUUC-Fso-038141	Fusarium solani	43.53	4.00e-16	79.30
IUUC-Gga-041201	Gallus gallus	63.85	5.00e-129	454.00
IUUC-Ggo-045429	Gorilla gorilla	77.44	1.00e-154	539.00
IUUC-Hsa-046191	Homo sapiens	75.75	8.00e-161	559.00
IUUC-Itr-048018	Ictidomys tridecemlineatus	78.59	1.00e-146	512.00
IUUC-Lch-049498	Latimeria chalumnae	60.16	5.00e-128	451.00
IUUC-Laf-054239	Loxodonta africana	69.63	5.00e-124	437.00
IUUC-Meu-056382	Macropus eugenii	70.95	1.00e-142	499.00
IUUC-Mor-056917	Magnaporthe oryzae	39.08	5.00e-13	69.30
IUUC-Mla-058935	Melampsora laricipopulina	36.59	2.00e-08	54.70
IUUC-Mga-059435	Meleagris gallopavo	70.59	2.00e-68	251.00
IUUC-Mmr-061513	Microcebus murinus	77.13	3.00e-159	554.00
IUUC-Mdo-063028	Monodelphis domestica	70.03	3.00e-145	508.00
IUUC-Mpu-066370	Mustela putorius furo	78.09	1.00e-160	559.00
IUUC-Mlu-067271	Myotis lucifugus	71.47	7.00e-126	443.00
IUUC-Nle-069207	Nomascus leucogenys	77.27	3.00e-161	561.00
IUUC-Opr-070704	Ochotona princeps	72.54	5.00e-95	340.00
IUUC-Oan-072837	Ornithorhynchus anatinus	66.94	2.00e-134	471.00
IUUC-Ocu-074671	Oryctolagus cuniculus	78.45	1.00e-119	422.00
IUUC-Oga-089083	Otolemur garnettii	76.83	3.00e-164	571.00
IUUC-Oar-089254	Ovis aries	76.61	4.00e-106	377.00
IUUC-Ptr-090940	Pan troglodytes	77.45	1.00e-158	552.00
IUUC-Pan-092636	Papio anubis	76.37	3.00e-156	544.00
IUUC-Psi-093435	Pelodiscus sinensis	73.08	3.00e-92	331.00
IUUC-Pab-098525	Pongo abelii	77.84	1.00e-156	546.00
IUUC-Pva-102395	Pteropus vampyrus	74.69	1.00e-158	552.00
IUUC-Pgr-103263	Puccinia graminis	42.47	1.00e-10	62.40
IUUC-Rno-105789	Rattus norvegicus	95.28	0.00e+00	645.00
IUUC-Sha-107305	Sarcophilus harrisii	74.44	4.00e-95	340.00
IUUC-Ssc-115598	Sus scrofa	76.49	2.00e-153	535.00
IUUC-Tgu-116463	Taeniopygia guttata	65.35	1.00e-124	439.00
IUUC-Tsy-118915	Tarsius syrichta	77.55	3.00e-105	374.00
IUUC-Tme-126970	Tuber melanosporum	49.06	1.00e-12	68.20
IUUC-Tbe-127906	Tupaia belangeri	64.05	3.00e-79	287.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence