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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018340
Ensembl Protein ID F09E5.1
UniProt Accession Q19266; A7VJC8; KPC3_CAEEL
Genbank Protein ID BAF80143.1; AAB88885.1; CCD68754.1
Protein Name Protein kinase C-like 3; Atypical protein kinase C-3
Genbank Nucleotide ID AB007320; AF025666; FO081044
Gene Name pkc-3; aPKC; F09E5.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004034 F09E5.1 F09E5.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UFD/PB1 58.43 0.00e+00 705.00 IUUC-Hsa-046991
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Required for the normal progression of embryogenesis and viability of the organism (PubMed:9422779). Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3 (PubMed:9716526, PubMed:9834192). Required for epithelial cell polarity in the distal spermatheca (PubMed:15151982). Phosphorylates serine residues of num-1 (PubMed:11134025). Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury (PubMed:19380113).
 Required for the normal progression of embryogenesis and viability of the organism (PubMed:9422779). Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3 (PubMed:9716526, PubMed:9834192). Required for epithelial cell polarity in the distal spermatheca (PubMed:15151982). Phosphorylates serine residues of num-1 (PubMed:11134025). Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury (PubMed:19380113).
Protein Sequence
(Fasta)
MSSPTSLEED GDIKLKTRFQ GQVVVLYARP PLILDDFFAL LKDACKQHKK QDITVKWIDE 60
DGDPISIDSQ MELDEAVRCL NSSQEAELNI HVFVGKPELP GLPCQGEDKT VYRRGARRWK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018340|ULD,PB1|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATGTCGTCT CCGACATCAT TAGAGGAGGA CGGAGATATT AAGCTAAAAA CGAGGTTTCA 60
AGGACAGGTG AGATATGAAA AGTGGCTTTT GAAATGCTCA AAAATCGAGA AATACCCTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018340|ULD,PB1|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0278--Fertilization
KW-0306--Gastrulation
KW-0334--Gonadal differentiation
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000961--AGC-kinase_C
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C
PRINTS

PR00008--DAGPEDOMAIN
SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005938--C:cell cortex
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0004672--F:protein kinase activity
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0008105--P:asymmetric protein localization
GO:0030154--P:cell differentiation
GO:0050832--P:defense response to fungus
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0007163--P:establishment or maintenance of cell polarity
GO:0007369--P:gastrulation
GO:0008406--P:gonad development
GO:0007506--P:gonadal mesoderm development
GO:0035556--P:intracellular signal transduction
GO:0018105--P:peptidyl-serine phosphorylation
GO:0009611--P:response to wounding
GO:0007338--P:single fertilization
KEGG cel:CELE_F09E5.1
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001764 Ailuropoda melanoleuca 61.41 0.00e+00 640.00
IUUC-Apl-003711 Anas platyrhynchos 59.97 0.00e+00 679.00
IUUC-Aca-005142 Anolis carolinensis 57.53 0.00e+00 672.00
IUUC-Ame-010977 Astyanax mexicanus 57.70 0.00e+00 663.00
IUUC-Bta-013414 Bos taurus 57.81 0.00e+00 678.00
IUUC-Cja-019802 Callithrix jacchus 59.10 0.00e+00 665.00
IUUC-Cfa-021236 Canis familiaris 56.72 0.00e+00 667.00
IUUC-Cpo-022127 Cavia porcellus 58.00 0.00e+00 650.00
IUUC-Csa-023332 Chlorocebus sabaeus 62.45 4.00e-176 609.00
IUUC-Cho-025054 Choloepus hoffmanni 66.42 2.00e-43 168.00
IUUC-Cin-025740 Ciona intestinalis 66.13 7.00e-147 512.00
IUUC-Csv-026145 Ciona savignyi 66.13 1.00e-147 514.00
IUUC-Dre-028444 Danio rerio 58.10 0.00e+00 658.00
IUUC-Dno-029228 Dasypus novemcinctus 72.84 1.00e-136 478.00
IUUC-Dme-031630 Drosophila melanogaster 70.57 2.00e-147 514.00
IUUC-Ete-032633 Echinops telfairi 52.75 2.00e-100 358.00
IUUC-Eca-033572 Equus caballus 59.20 0.00e+00 672.00
IUUC-Eeu-035110 Erinaceus europaeus 58.36 0.00e+00 672.00
IUUC-Fca-035559 Felis catus 57.64 0.00e+00 680.00
IUUC-Fal-036953 Ficedula albicollis 60.14 0.00e+00 683.00
IUUC-Gmo-039334 Gadus morhua 57.83 0.00e+00 682.00
IUUC-Gga-040223 Gallus gallus 59.45 0.00e+00 689.00
IUUC-Gac-042113 Gasterosteus aculeatus 57.38 0.00e+00 685.00
IUUC-Ggo-044520 Gorilla gorilla 56.71 0.00e+00 634.00
IUUC-Hsa-046991 Homo sapiens 58.43 0.00e+00 678.00
IUUC-Lch-050263 Latimeria chalumnae 56.59 0.00e+00 654.00
IUUC-Loc-052221 Lepisosteus oculatus 58.57 0.00e+00 667.00
IUUC-Laf-053591 Loxodonta africana 58.53 0.00e+00 680.00
IUUC-Mcc-055118 Macaca mulatta 58.33 0.00e+00 675.00
IUUC-Mga-059886 Meleagris gallopavo 59.97 0.00e+00 679.00
IUUC-Mmr-060926 Microcebus murinus 58.60 0.00e+00 678.00
IUUC-Mdo-062698 Monodelphis domestica 55.69 0.00e+00 654.00
IUUC-Mmu-063689 Mus musculus 58.53 0.00e+00 679.00
IUUC-Mpu-066630 Mustela putorius furo 58.53 0.00e+00 678.00
IUUC-Mlu-067416 Myotis lucifugus 54.35 0.00e+00 639.00
IUUC-Nle-069811 Nomascus leucogenys 58.43 0.00e+00 677.00
IUUC-Opr-070466 Ochotona princeps 56.83 3.00e-138 484.00
IUUC-Ont-072278 Oreochromis niloticus 58.67 0.00e+00 660.00
IUUC-Oan-073651 Ornithorhynchus anatinus 69.83 1.00e-150 524.00
IUUC-Ocu-074383 Oryctolagus cuniculus 58.53 0.00e+00 678.00
IUUC-Ola-087283 Oryzias latipes 57.04 1.00e-158 551.00
IUUC-Oga-088337 Otolemur garnettii 52.36 2.00e-167 580.00
IUUC-Oar-089954 Ovis aries 58.12 0.00e+00 674.00
IUUC-Ptr-091673 Pan troglodytes 58.43 0.00e+00 678.00
IUUC-Pan-092494 Papio anubis 58.43 0.00e+00 676.00
IUUC-Psi-094044 Pelodiscus sinensis 58.77 0.00e+00 676.00
IUUC-Pfo-096661 Poecilia formosa 57.66 0.00e+00 665.00
IUUC-Pab-097659 Pongo abelii 58.19 0.00e+00 672.00
IUUC-Pca-101107 Procavia capensis 69.97 1.00e-149 521.00
IUUC-Rno-105790 Rattus norvegicus 58.53 0.00e+00 678.00
IUUC-Sha-106895 Sarcophilus harrisii 57.43 0.00e+00 660.00
IUUC-Sar-113513 Sorex araneus 52.11 6.00e-89 320.00
IUUC-Ssc-115835 Sus scrofa 61.27 0.00e+00 643.00
IUUC-Tgu-116874 Taeniopygia guttata 59.63 0.00e+00 692.00
IUUC-Tru-117823 Takifugu rubripes 57.40 0.00e+00 665.00
IUUC-Tsy-119154 Tarsius syrichta 59.20 0.00e+00 672.00
IUUC-Tni-119968 Tetraodon nigroviridis 56.84 0.00e+00 649.00
IUUC-Tbe-127238 Tupaia belangeri 46.82 4.00e-120 423.00
IUUC-Ttr-129208 Tursiops truncatus 58.53 0.00e+00 677.00
IUUC-Vpa-130363 Vicugna pacos 72.13 2.00e-128 451.00
IUUC-Xtr-132652 Xenopus tropicalis 55.41 0.00e+00 640.00
Created Date 25-Jun-2017

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