iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071477

Ensembl Protein ID

ENSONIP00000021737.1

UniProt Accession

I3KKU2; I3KKU2_ORENI

Genbank Protein ID

ENSONIP00000021737

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Genbank Nucleotide ID

AERX01047748

Gene Name

rnf168; LOC100691685; RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000017234.1	ENSONIT00000021756.1	ENSONIP00000021737.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-06	29.2	28	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle f++ p++lpC H+f++ C+ + +       + +  CP Cr
   Q: 28   CPVCLEIFME-PVTLPCTHTFCKVCFlESV------DKATLCCPMCR 67
           **********.9*************97777......9*********8 PP

Organism

Oreochromis niloticus

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

MSPVSEVESS DVGGRGQETT LSKEDCLCPV CLEIFMEPVT LPCTHTFCKV CFLESVDKAT 60
LCCPMCRKRV STWARLHSRN NTLVNETLWR RVQTCFPRQC EHRLSGQGEV EDPHSALVCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTCCGG TGTCAGAGGT TGAGAGCTCG GACGTAGGGG GGCGGGGCCA GGAGACTACG 60
CTGTCCAAAG AAGACTGTCT GTGTCCCGTC TGCCTCGAGA TCTTCATGGA GCCCGTCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	37.04	2.00e-11	63.50
IUUC-Aml-001573	Ailuropoda melanoleuca	44.93	8.00e-33	135.00
IUUC-Apl-003963	Anas platyrhynchos	39.47	6.00e-41	162.00
IUUC-Aca-004420	Anolis carolinensis	57.55	1.00e-36	148.00
IUUC-Ath-007019	Arabidopsis thaliana	40.54	3.00e-10	60.80
IUUC-Ame-011521	Astyanax mexicanus	42.01	3.00e-60	226.00
IUUC-Bta-013002	Bos taurus	52.54	4.00e-34	139.00
IUUC-Cja-019945	Callithrix jacchus	44.93	3.00e-33	136.00
IUUC-Cfa-020533	Canis familiaris	44.20	2.00e-32	134.00
IUUC-Cpo-021643	Cavia porcellus	51.72	2.00e-33	137.00
IUUC-Csa-023638	Chlorocebus sabaeus	45.09	2.00e-38	154.00
IUUC-Cho-024319	Choloepus hoffmanni	51.67	8.00e-33	135.00
IUUC-Cin-025679	Ciona intestinalis	36.93	2.00e-26	113.00
IUUC-Csv-026052	Ciona savignyi	31.28	2.00e-25	109.00
IUUC-Cme-027197	Cyanidioschyzon merolae	48.89	4.00e-08	53.90
IUUC-Dre-028519	Danio rerio	45.43	5.00e-68	251.00
IUUC-Dno-029294	Dasypus novemcinctus	50.85	2.00e-33	137.00
IUUC-Ete-032714	Echinops telfairi	50.91	1.00e-29	124.00
IUUC-Eca-033343	Equus caballus	45.13	6.00e-37	148.00
IUUC-Fca-036251	Felis catus	43.59	7.00e-36	145.00
IUUC-Fal-037048	Ficedula albicollis	46.98	2.00e-44	173.00
IUUC-Gmo-039400	Gadus morhua	60.71	2.00e-42	164.00
IUUC-Gga-040444	Gallus gallus	43.10	2.00e-45	177.00
IUUC-Gac-041735	Gasterosteus aculeatus	61.75	4.00e-69	254.00
IUUC-Gma-044332	Glycine max	36.27	4.00e-13	69.30
IUUC-Hsa-046424	Homo sapiens	46.90	5.00e-36	145.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	54.02	2.00e-29	124.00
IUUC-Lch-050649	Latimeria chalumnae	53.29	1.00e-38	154.00
IUUC-Loc-051847	Lepisosteus oculatus	39.91	2.00e-54	207.00
IUUC-Laf-054076	Loxodonta africana	51.25	3.00e-34	137.00
IUUC-Mcc-055360	Macaca mulatta	51.72	1.00e-33	138.00
IUUC-Meu-056684	Macropus eugenii	50.29	4.00e-36	146.00
IUUC-Mtr-058007	Medicago truncatula	40.74	6.00e-13	68.60
IUUC-Mga-059699	Meleagris gallopavo	44.98	5.00e-45	175.00
IUUC-Mmr-060779	Microcebus murinus	38.57	3.00e-35	143.00
IUUC-Mdo-062225	Monodelphis domestica	50.00	2.00e-34	140.00
IUUC-Mmu-064239	Mus musculus	54.22	8.00e-28	118.00
IUUC-Mpu-066141	Mustela putorius furo	42.92	1.00e-37	151.00
IUUC-Mlu-067945	Myotis lucifugus	45.85	1.00e-39	157.00
IUUC-Nle-069769	Nomascus leucogenys	45.74	6.00e-33	135.00
IUUC-Opr-070905	Ochotona princeps	38.56	2.00e-30	127.00
IUUC-Oan-073587	Ornithorhynchus anatinus	54.47	1.00e-34	138.00
IUUC-Ocu-073832	Oryctolagus cuniculus	39.83	6.00e-36	145.00
IUUC-Obr-076219	Oryza brachyantha	38.27	9.00e-11	61.20
IUUC-Ogl-077658	Oryza glaberrima	37.63	3.00e-11	63.20
IUUC-Oin-079383	Oryza indica	37.63	2.00e-11	63.50
IUUC-Ome-081482	Oryza meridionalis	40.74	2.00e-11	63.50
IUUC-Oni-083025	Oryza nivara	37.63	2.00e-11	63.50
IUUC-Opu-083547	Oryza punctata	41.33	7.00e-11	61.60
IUUC-Oru-084946	Oryza rufipogon	31.78	2.00e-07	50.10
IUUC-Osa-085978	Oryza sativa	37.63	2.00e-11	63.50
IUUC-Ola-086478	Oryzias latipes	70.80	5.00e-55	206.00
IUUC-Oga-088318	Otolemur garnettii	49.54	1.00e-28	121.00
IUUC-Oar-089647	Ovis aries	51.69	6.00e-34	139.00
IUUC-Ptr-090516	Pan troglodytes	47.09	2.00e-36	147.00
IUUC-Pan-092302	Papio anubis	45.98	1.00e-35	144.00
IUUC-Psi-093604	Pelodiscus sinensis	49.32	5.00e-39	155.00
IUUC-Pfo-096441	Poecilia formosa	52.12	3.00e-68	252.00
IUUC-Pab-097729	Pongo abelii	46.02	3.00e-34	140.00
IUUC-Pop-099737	Populus trichocarpa	39.51	5.00e-11	63.50
IUUC-Pca-100552	Procavia capensis	54.22	7.00e-28	119.00
IUUC-Ppe-102024	Prunus persica	43.21	7.00e-13	70.10
IUUC-Pva-102780	Pteropus vampyrus	49.15	9.00e-33	135.00
IUUC-Rno-105461	Rattus norvegicus	42.79	1.00e-33	138.00
IUUC-Sha-106809	Sarcophilus harrisii	46.22	3.00e-37	149.00
IUUC-Sly-111317	Solanum lycopersicum	41.18	3.00e-14	73.20
IUUC-Stu-112446	Solanum tuberosum	41.98	1.00e-13	70.90
IUUC-Sar-113579	Sorex araneus	42.57	1.00e-34	140.00
IUUC-Sbi-113834	Sorghum bicolor	39.76	6.00e-12	65.10
IUUC-Tgu-117187	Taeniopygia guttata	49.75	1.00e-39	156.00
IUUC-Tru-118182	Takifugu rubripes	48.98	6.00e-61	228.00
IUUC-Tni-120205	Tetraodon nigroviridis	50.66	4.00e-61	228.00
IUUC-Tca-121416	Theobroma cacao	43.42	5.00e-13	68.60
IUUC-Tvi-122557	Trichoderma virens	45.65	5.00e-06	45.80
IUUC-Tae-123092	Triticum aestivum	37.04	2.00e-11	63.50
IUUC-Tur-126688	Triticum urartu	35.80	4.00e-11	62.00
IUUC-Tbe-127622	Tupaia belangeri	46.15	3.00e-38	153.00
IUUC-Ttr-128988	Tursiops truncatus	44.10	8.00e-33	135.00
IUUC-Vpa-130302	Vicugna pacos	51.28	5.00e-33	135.00
IUUC-Vvi-131424	Vitis vinifera	40.74	2.00e-11	63.50
IUUC-Xtr-132196	Xenopus tropicalis	42.86	4.00e-38	152.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence