iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118182

UUCD1 version

UUC-TaR-00134

Ensembl Protein ID

ENSTRUP00000006898.1

UniProt Accession

H2S3C6; H2S3C6_TAKRU

Protein Name

E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168

Gene Name

rnf168; RNF168

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000002958.1	ENSTRUT00000006943.1	ENSTRUP00000006898.1
ENSTRUG00000002958.1	ENSTRUT00000006944.1	ENSTRUP00000006899.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/MIU	49.59	5.00e-32	136.00	IUUC-Hsa-046424
UBD/Alpha-Helix/UMI	49.59	5.00e-32	136.00	IUUC-Hsa-046424
E3 activity/RING/RING	49.59	5.00e-32	136.00	IUUC-Hsa-046424

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Takifugu rubripes

Functional Description
(View)

E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Protein Sequence
(Fasta)

ISNVKMSGRG GRRESTLTLQ DCRCPVCLEI LCEPVTLPCT HTFCKGCFLE SVDKATLCCP 60
LCRKRVSTWA RQNSRNNTLV NQQLWNQIQD QFPLHCQRRL SGQDGNVCVV AVCVPRVSEP 120

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Nucleotide Sequence
(Fasta)

CTGGATTCCG CGGGTAGTTG ATGCTAACAA AGCAATATGT CAGACTGACT AGTTTATTCA 60
CTTGGTGAAT TATGTAAGTT ATTACATCTC TGGTGAGGAT GTCTTGCATG AATTACACGG 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034725--RNF168
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000755	Aegilops tauschii	40.79	1.00e-10	60.80
IUUC-Aml-001573	Ailuropoda melanoleuca	51.72	3.00e-34	140.00
IUUC-Apl-003963	Anas platyrhynchos	52.42	9.00e-38	151.00
IUUC-Aca-004420	Anolis carolinensis	57.89	2.00e-38	153.00
IUUC-Ame-011521	Astyanax mexicanus	41.52	2.00e-59	223.00
IUUC-Bgr-011969	Blumeria graminis	37.70	7.00e-07	48.50
IUUC-Bta-013002	Bos taurus	52.85	8.00e-36	144.00
IUUC-Cja-019945	Callithrix jacchus	50.00	7.00e-33	135.00
IUUC-Cfa-020533	Canis familiaris	48.33	4.00e-32	132.00
IUUC-Cpo-021643	Cavia porcellus	48.39	3.00e-35	142.00
IUUC-Csa-023638	Chlorocebus sabaeus	43.44	6.00e-34	139.00
IUUC-Cho-024319	Choloepus hoffmanni	52.17	5.00e-33	135.00
IUUC-Cin-025679	Ciona intestinalis	33.79	2.00e-25	109.00
IUUC-Csv-026052	Ciona savignyi	34.24	5.00e-25	107.00
IUUC-Dre-028519	Danio rerio	44.13	2.00e-64	239.00
IUUC-Dno-029294	Dasypus novemcinctus	50.83	4.00e-34	139.00
IUUC-Ete-032714	Echinops telfairi	48.70	1.00e-29	124.00
IUUC-Eca-033343	Equus caballus	42.42	4.00e-36	145.00
IUUC-Fca-036251	Felis catus	50.00	7.00e-34	138.00
IUUC-Fal-037048	Ficedula albicollis	44.93	4.00e-39	156.00
IUUC-Gmo-039400	Gadus morhua	64.84	9.00e-44	168.00
IUUC-Gga-040444	Gallus gallus	52.38	6.00e-39	155.00
IUUC-Gac-041735	Gasterosteus aculeatus	59.00	5.00e-60	223.00
IUUC-Gma-044332	Glycine max	44.74	2.00e-12	66.60
IUUC-Hsa-046424	Homo sapiens	49.59	4.00e-34	139.00
IUUC-Itr-048965	Ictidomys tridecemlineatus	51.65	4.00e-29	122.00
IUUC-Lch-050649	Latimeria chalumnae	55.28	2.00e-40	160.00
IUUC-Loc-051847	Lepisosteus oculatus	47.58	1.00e-43	170.00
IUUC-Laf-054076	Loxodonta africana	50.42	3.00e-32	131.00
IUUC-Mcc-055360	Macaca mulatta	51.33	3.00e-32	133.00
IUUC-Meu-056684	Macropus eugenii	50.41	4.00e-33	135.00
IUUC-Mtr-058007	Medicago truncatula	39.78	3.00e-12	65.90
IUUC-Mga-059699	Meleagris gallopavo	53.74	2.00e-39	156.00
IUUC-Mmr-060779	Microcebus murinus	50.00	2.00e-33	137.00
IUUC-Mdo-062225	Monodelphis domestica	49.59	2.00e-35	143.00
IUUC-Mmu-064239	Mus musculus	50.00	7.00e-28	118.00
IUUC-Mpu-066141	Mustela putorius furo	42.13	9.00e-35	141.00
IUUC-Mlu-067945	Myotis lucifugus	42.60	1.00e-34	141.00
IUUC-Nle-069769	Nomascus leucogenys	47.50	3.00e-31	130.00
IUUC-Opr-070905	Ochotona princeps	57.61	2.00e-30	127.00
IUUC-Ont-071477	Oreochromis niloticus	46.92	6.00e-57	214.00
IUUC-Oan-073587	Ornithorhynchus anatinus	53.66	4.00e-35	139.00
IUUC-Ocu-073832	Oryctolagus cuniculus	38.68	4.00e-34	139.00
IUUC-Obr-076219	Oryza brachyantha	45.71	1.00e-10	60.80
IUUC-Ogl-077658	Oryza glaberrima	47.14	4.00e-11	62.40
IUUC-Ogu-078203	Oryza glumaepatula	45.71	1.00e-10	60.50
IUUC-Oin-079383	Oryza indica	44.74	4.00e-11	62.40
IUUC-Ome-081482	Oryza meridionalis	44.74	4.00e-11	62.40
IUUC-Oni-083025	Oryza nivara	44.74	4.00e-11	62.40
IUUC-Opu-083547	Oryza punctata	47.14	5.00e-11	62.00
IUUC-Oru-084946	Oryza rufipogon	38.10	5.00e-07	48.90
IUUC-Osa-085978	Oryza sativa	44.74	4.00e-11	62.40
IUUC-Ola-086478	Oryzias latipes	70.99	7.00e-51	192.00
IUUC-Oga-088318	Otolemur garnettii	51.38	1.00e-29	124.00
IUUC-Oar-089647	Ovis aries	51.61	9.00e-36	144.00
IUUC-Ptr-090516	Pan troglodytes	49.59	3.00e-34	139.00
IUUC-Pan-092302	Papio anubis	51.33	1.00e-33	137.00
IUUC-Psi-093604	Pelodiscus sinensis	51.20	6.00e-37	149.00
IUUC-Pfo-096441	Poecilia formosa	53.96	4.00e-54	205.00
IUUC-Pab-097729	Pongo abelii	48.33	1.00e-32	134.00
IUUC-Pca-100552	Procavia capensis	51.09	3.00e-28	119.00
IUUC-Ppe-102024	Prunus persica	46.05	5.00e-11	63.50
IUUC-Pva-102780	Pteropus vampyrus	47.15	2.00e-32	134.00
IUUC-Rno-105461	Rattus norvegicus	48.78	4.00e-33	135.00
IUUC-Sha-106809	Sarcophilus harrisii	45.50	6.00e-37	148.00
IUUC-Spo-108067	Schizosaccharomyces pombe	27.27	1.00e-06	47.80
IUUC-Sly-110934	Solanum lycopersicum	42.05	2.00e-13	69.70
IUUC-Stu-112446	Solanum tuberosum	44.44	3.00e-13	69.70
IUUC-Sar-113579	Sorex araneus	49.15	1.00e-33	137.00
IUUC-Sbi-113834	Sorghum bicolor	41.46	1.00e-11	64.30
IUUC-Tgu-117187	Taeniopygia guttata	53.28	3.00e-38	151.00
IUUC-Tni-120205	Tetraodon nigroviridis	66.67	3.00e-83	301.00
IUUC-Tca-121416	Theobroma cacao	46.05	2.00e-12	67.00
IUUC-Tvi-122557	Trichoderma virens	43.75	7.00e-06	45.40
IUUC-Tae-123092	Triticum aestivum	40.79	1.00e-10	60.80
IUUC-Tur-126688	Triticum urartu	39.47	2.00e-10	59.70
IUUC-Tbe-127622	Tupaia belangeri	50.00	2.00e-35	144.00
IUUC-Ttr-128988	Tursiops truncatus	48.78	7.00e-33	135.00
IUUC-Vpa-130302	Vicugna pacos	49.18	2.00e-33	137.00
IUUC-Vvi-131424	Vitis vinifera	44.74	5.00e-11	61.60
IUUC-Xtr-132196	Xenopus tropicalis	45.09	3.00e-40	159.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence