iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164292.12	ENST00000506959.5	ENSP00000423688.1
ENSG00000164292.12	ENST00000506817.1	ENSP00000426479.1
ENSG00000164292.12	ENST00000379982.7	ENSP00000369318.3
ENSG00000164292.12	ENST00000510623.1	ENSP00000423652.1
ENSG00000164292.12	ENST00000502541.1	ENSP00000421875.1
ENSG00000164292.12	ENST00000504179.5	ENSP00000422360.1
ENSG00000164292.12	ENST00000510313.1	ENSP00000424844.1
ENSG00000164292.12	ENST00000503737.1	ENSP00000426390.1
ENSG00000164292.12	ENST00000513091.1	ENSP00000425342.1
ENSG00000164292.12	ENST00000514198.1	ENSP00000424700.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	18835386

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.50e-28	99.9	420	482

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgk 64
           aDv+++++g+ ++ah+++L a+++v+ a+f+++  e k +  + + +v+ e f  +l++lYt++
   Q: 420  ADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAK-SVLIPVYGVSKETFLSFLEYLYTDS 482
           7***********************************99.55566667***************86 PP

Organism

Homo sapiens

Functional Description
(View)

Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9.

Protein Sequence
(Fasta)

MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV ARPVFTEYQA 60
SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY NVNDKFSFHE VKDNYIPVIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTTCTGCC ATGATTGGAA ATTTCCTGAG GCCTCCCCAG AAGCAGAATC CTGTACAGCC 60
TGCAGAATTG TGAGCCATTA AATCTCTTTT CTTTATAAAT TACCTAGTCG CAGGTATGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport

Interpro

IPR000210--BTB/POZ_dom
IPR027417--P-loop_NTPase
IPR031260--RhoBTB3
IPR011333--SKP1/BTB/POZ
IPR001806--Small_GTPase

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF00071--Ras

SMART

SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0032588--C:trans-Golgi network membrane
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0017137--F:Rab GTPase binding
GO:0008584--P:male gonad development
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0007264--P:small GTPase mediated signal transduction

KEGG

hsa:22836

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001703	Ailuropoda melanoleuca	98.03	0.00e+00	1252.00
IUUC-Apl-003597	Anas platyrhynchos	72.25	0.00e+00	766.00
IUUC-Aca-005165	Anolis carolinensis	75.04	0.00e+00	907.00
IUUC-Ame-011844	Astyanax mexicanus	44.64	2.00e-133	469.00
IUUC-Bta-013209	Bos taurus	95.59	0.00e+00	1207.00
IUUC-Cja-019287	Callithrix jacchus	98.69	0.00e+00	1263.00
IUUC-Cfa-021000	Canis familiaris	97.12	0.00e+00	848.00
IUUC-Cpo-022105	Cavia porcellus	92.65	0.00e+00	1159.00
IUUC-Csa-023505	Chlorocebus sabaeus	99.18	0.00e+00	1268.00
IUUC-Cho-024673	Choloepus hoffmanni	89.36	0.00e+00	1101.00
IUUC-Dre-028304	Danio rerio	45.61	5.00e-152	531.00
IUUC-Dno-029451	Dasypus novemcinctus	93.64	0.00e+00	1194.00
IUUC-Dor-030155	Dipodomys ordii	87.07	0.00e+00	1090.00
IUUC-Ete-033024	Echinops telfairi	85.27	0.00e+00	1078.00
IUUC-Eca-034120	Equus caballus	97.38	0.00e+00	1214.00
IUUC-Eeu-034621	Erinaceus europaeus	87.40	0.00e+00	1094.00
IUUC-Fca-035426	Felis catus	97.87	0.00e+00	1222.00
IUUC-Fal-037409	Ficedula albicollis	70.85	0.00e+00	884.00
IUUC-Gmo-038756	Gadus morhua	46.33	3.00e-142	498.00
IUUC-Gga-040759	Gallus gallus	71.29	0.00e+00	897.00
IUUC-Gac-041780	Gasterosteus aculeatus	47.90	4.00e-147	514.00
IUUC-Ggo-044917	Gorilla gorilla	99.51	0.00e+00	1268.00
IUUC-Itr-048426	Ictidomys tridecemlineatus	96.06	2.00e-162	564.00
IUUC-Lch-049928	Latimeria chalumnae	54.59	0.00e+00	637.00
IUUC-Loc-052892	Lepisosteus oculatus	53.28	2.00e-139	489.00
IUUC-Laf-053969	Loxodonta africana	93.33	0.00e+00	1153.00
IUUC-Mcc-055592	Macaca mulatta	99.18	0.00e+00	1268.00
IUUC-Meu-056177	Macropus eugenii	65.83	3.00e-128	452.00
IUUC-Mga-059268	Meleagris gallopavo	52.92	3.00e-153	535.00
IUUC-Mmr-060912	Microcebus murinus	98.36	0.00e+00	1231.00
IUUC-Mdo-062861	Monodelphis domestica	78.89	0.00e+00	930.00
IUUC-Mmu-063969	Mus musculus	95.74	0.00e+00	1229.00
IUUC-Mpu-065970	Mustela putorius furo	97.71	0.00e+00	1250.00
IUUC-Mlu-067698	Myotis lucifugus	96.57	0.00e+00	1223.00
IUUC-Nle-069460	Nomascus leucogenys	99.35	0.00e+00	1272.00
IUUC-Opr-070677	Ochotona princeps	94.93	0.00e+00	1194.00
IUUC-Ont-072661	Oreochromis niloticus	46.20	2.00e-155	542.00
IUUC-Oan-073683	Ornithorhynchus anatinus	81.77	0.00e+00	871.00
IUUC-Ocu-074387	Oryctolagus cuniculus	93.95	0.00e+00	1175.00
IUUC-Ola-087205	Oryzias latipes	46.70	3.00e-151	528.00
IUUC-Oga-088541	Otolemur garnettii	95.25	0.00e+00	1190.00
IUUC-Oar-089303	Ovis aries	95.10	0.00e+00	1202.00
IUUC-Ptr-091617	Pan troglodytes	99.67	0.00e+00	1270.00
IUUC-Pan-092131	Papio anubis	99.35	0.00e+00	1268.00
IUUC-Psi-092934	Pelodiscus sinensis	76.31	0.00e+00	903.00
IUUC-Pfo-097444	Poecilia formosa	45.91	1.00e-146	513.00
IUUC-Pab-098318	Pongo abelii	99.36	0.00e+00	981.00
IUUC-Pca-100096	Procavia capensis	90.09	0.00e+00	996.00
IUUC-Pva-102344	Pteropus vampyrus	88.05	0.00e+00	1099.00
IUUC-Rno-105393	Rattus norvegicus	96.07	0.00e+00	1233.00
IUUC-Sha-106830	Sarcophilus harrisii	82.54	0.00e+00	1017.00
IUUC-Sar-113635	Sorex araneus	82.43	0.00e+00	869.00
IUUC-Ssc-115928	Sus scrofa	96.74	0.00e+00	1234.00
IUUC-Tgu-116531	Taeniopygia guttata	71.13	0.00e+00	872.00
IUUC-Tru-117997	Takifugu rubripes	46.17	2.00e-148	519.00
IUUC-Tsy-119040	Tarsius syrichta	88.22	0.00e+00	1084.00
IUUC-Tni-119855	Tetraodon nigroviridis	46.09	4.00e-148	518.00
IUUC-Tbe-127588	Tupaia belangeri	81.24	0.00e+00	674.00
IUUC-Ttr-128334	Tursiops truncatus	89.27	0.00e+00	962.00
IUUC-Uma-129614	Ustilago maydis	25.51	1.50e-02	33.90
IUUC-Vpa-130561	Vicugna pacos	92.96	0.00e+00	1149.00
IUUC-Xtr-132632	Xenopus tropicalis	57.99	3.00e-176	611.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence