iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWAS Central	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-30	104.3	178	215
UBD/Beta-Prp	6.00e-52	178.3	280	539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+af  s++++ +GsdD+ +k+W +++g+ll
   Q: 178  GHLSSVYCVAFdrSGRRIFTGSDDCLVKIWATDDGRLL 215
           8**********96669******************9987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl........lrslsgheae..vtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsls 101
           +++l+++++dgti  w+++ +++        + + s    +  +++ +fs+ g ++ tgs+D++i+++    + ++ +  l+ h+d+v++++
   Q: 280  NRYLTSTGADGTICFWQWHVKTMkfrdrpvkFTERSRP--GvqISCSSFSSGGMFITTGSTDHVIRIYylGSEVPEKIAELESHTDKVVAVQ 369
           689*************9998777667776433333333..35599***********************877789****************** PP
   S: 102  fspsg..dklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl 175
           f+ +g   ++vsGs+d t+r+w+ +++++ +                  +++++  v++v+++  +  ++++ ++  +++W++ tg+ll+tl
   Q: 370  FCNNGdsLRFVSGSRDGTARIWQYQQQEWKSIvldmatkmtgnnlpsgEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTL 461
           ***8832468*******************999************998888888889************************************ PP
   S: 176  tgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiri 248
           +g h+d v  l+   fd+  + ++s+++dg + +wdl +g+ +r + +         v + +fsp++++++++ s+g + +
   Q: 462  SG-HDDEVFVLEahpFDQ--RIILSAGHDGNIFIWDLDRGTKIRNYFNMIegqghGAVFDCKFSPDGNHFACTDSHGHLLL 539
           *9.*********555555..99********************98887755455567788899999***9999999988766 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Protein Sequence
(Fasta)

MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG KEHRRSFEDL 60
VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV GRQSLLRDAK DCKSTLWNGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCCTTCC TCCTCCGCCT CCTCAGCTCT TGGGCTAGAA TATCTATGGG TCGAAACGTG 60
ATGCGATGAA TTCGAGAGAG AGCGAAACTA GGACGAGGAG TGCGGCGGAA GCGGCGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

hsa:254065

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001881	Ailuropoda melanoleuca	97.06	0.00e+00	3148.00
IUUC-Apl-004016	Anas platyrhynchos	80.04	0.00e+00	2264.00
IUUC-Aca-004722	Anolis carolinensis	78.31	0.00e+00	2211.00
IUUC-Ame-010602	Astyanax mexicanus	76.39	0.00e+00	1137.00
IUUC-Bta-013198	Bos taurus	95.78	0.00e+00	2868.00
IUUC-Cfa-020963	Canis familiaris	96.73	0.00e+00	3115.00
IUUC-Cpo-022448	Cavia porcellus	89.12	0.00e+00	2843.00
IUUC-Csa-023166	Chlorocebus sabaeus	99.40	0.00e+00	3063.00
IUUC-Cin-025553	Ciona intestinalis	38.35	1.00e-111	397.00
IUUC-Csv-025813	Ciona savignyi	43.49	0.00e+00	638.00
IUUC-Dre-028508	Danio rerio	65.83	0.00e+00	1886.00
IUUC-Dno-030070	Dasypus novemcinctus	93.51	0.00e+00	3013.00
IUUC-Dor-031052	Dipodomys ordii	79.71	0.00e+00	1434.00
IUUC-Ete-032650	Echinops telfairi	86.29	0.00e+00	1838.00
IUUC-Eca-033953	Equus caballus	97.12	0.00e+00	2809.00
IUUC-Eeu-034871	Erinaceus europaeus	82.86	0.00e+00	1345.00
IUUC-Fca-036099	Felis catus	96.56	0.00e+00	3150.00
IUUC-Fal-037246	Ficedula albicollis	81.01	0.00e+00	2438.00
IUUC-Gga-041097	Gallus gallus	82.46	0.00e+00	2528.00
IUUC-Gac-042435	Gasterosteus aculeatus	65.25	0.00e+00	1848.00
IUUC-Loc-051802	Lepisosteus oculatus	69.54	0.00e+00	2063.00
IUUC-Laf-053942	Loxodonta africana	96.08	0.00e+00	3014.00
IUUC-Mcc-054645	Macaca mulatta	99.52	0.00e+00	3069.00
IUUC-Meu-056321	Macropus eugenii	76.27	0.00e+00	1113.00
IUUC-Mga-060063	Meleagris gallopavo	83.11	0.00e+00	2477.00
IUUC-Mmr-061262	Microcebus murinus	96.33	0.00e+00	2997.00
IUUC-Mdo-062320	Monodelphis domestica	75.78	0.00e+00	2305.00
IUUC-Mmu-063163	Mus musculus	94.62	0.00e+00	3036.00
IUUC-Mpu-066628	Mustela putorius furo	96.61	0.00e+00	3155.00
IUUC-Mlu-068082	Myotis lucifugus	96.63	0.00e+00	2964.00
IUUC-Nle-069609	Nomascus leucogenys	99.40	0.00e+00	3079.00
IUUC-Ont-071589	Oreochromis niloticus	66.21	0.00e+00	1816.00
IUUC-Ocu-074122	Oryctolagus cuniculus	94.83	0.00e+00	2132.00
IUUC-Ola-086580	Oryzias latipes	66.20	0.00e+00	1883.00
IUUC-Oga-089053	Otolemur garnettii	95.45	0.00e+00	3092.00
IUUC-Oar-090042	Ovis aries	96.45	0.00e+00	3150.00
IUUC-Ptr-091268	Pan troglodytes	98.61	0.00e+00	3016.00
IUUC-Pan-092376	Papio anubis	99.46	0.00e+00	3068.00
IUUC-Psi-093408	Pelodiscus sinensis	81.32	0.00e+00	2531.00
IUUC-Pfo-096515	Poecilia formosa	66.33	0.00e+00	1787.00
IUUC-Pab-097672	Pongo abelii	97.41	0.00e+00	3019.00
IUUC-Pva-102512	Pteropus vampyrus	97.75	0.00e+00	2357.00
IUUC-Rno-105797	Rattus norvegicus	94.21	0.00e+00	2922.00
IUUC-Sha-107061	Sarcophilus harrisii	76.72	0.00e+00	2311.00
IUUC-Sit-110017	Setaria italica	29.00	2.00e-56	215.00
IUUC-Sar-113004	Sorex araneus	84.22	0.00e+00	1662.00
IUUC-Tgu-117254	Taeniopygia guttata	81.94	0.00e+00	2434.00
IUUC-Tru-118186	Takifugu rubripes	65.47	0.00e+00	1837.00
IUUC-Tsy-119003	Tarsius syrichta	90.34	0.00e+00	2723.00
IUUC-Tni-120110	Tetraodon nigroviridis	65.24	0.00e+00	1805.00
IUUC-Tbe-127813	Tupaia belangeri	78.35	0.00e+00	932.00
IUUC-Ttr-129265	Tursiops truncatus	93.01	0.00e+00	2849.00
IUUC-Vpa-130736	Vicugna pacos	90.29	0.00e+00	1498.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence