iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000063663.11	ENSMUST00000150434.7	ENSMUSP00000123588.1
ENSMUSG00000063663.11	ENSMUST00000041866.11	ENSMUSP00000134621.1
ENSMUSG00000063663.11	ENSMUST00000101283.3	ENSMUSP00000098841.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-31	108.0	178	215
UBD/Beta-Prp	4.50e-52	178.2	280	539

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+af  s++++ +GsdD+ +k+W +++g+ll
   Q: 178  GHLSSVYCVAFdrSGRRIFTGSDDCLVKIWATDDGRLL 215
           8**********96669******************9987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl........lrslsgheae..vtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvl 98
           +++l+++++dgti  w+++ +++        + + s    +  +++ +fs+ g ++ tgs+D++i+++    + ++ +  l+ h+d+v+
   Q: 280  TRYLTSTGADGTICFWQWHVKTMkfrdrpvkFTERSRP--GvqISCSSFSSGGMFITTGSTDHVIRIYylGSEIPEKIAELESHTDKVV 366
           589*************9998777667776433333333..35599***********************7777899************** PP
   S: 99   slsfspsg..dklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktg 169
           +++f+ +g   ++vsGs+d t+r+w+ +++++ +                  +++++  v++v+++  +  ++++ ++  +++W++ tg
   Q: 367  AVQFCNNGdsLRFVSGSRDGTARIWQYQQQEWKSIvldmatkmsgnnltsaEDKVTKLKVTMVAWDRYDTTVITAVNNFLLKVWNSVTG 455
           ******8832468*******************999************999989999999****************************** PP
   S: 170  kllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiri 248
           +ll+tl+g h+d v  l+   fd+  + ++s+++dg + +wdl +g+ +r + +         v + +fsp++++++++ s+g + +
   Q: 456  QLLHTLSG-HDDEVFVLEahpFDQ--RIILSAGHDGNIFIWDLDRGTKIRNYFNMIegqghGAVFDCKFSPDGNHFACTDSHGHLLL 539
           *******9.*********555555..99********************98887755455567788899999***9999999988766 PP

Organism

Mus musculus

Functional Description
(View)

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).

Protein Sequence
(Fasta)

MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG KEHRRSFEDL 60
VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV GRQSLLRDAK DCKSTLWNGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGCTCCTC CCTCTCCTTC TCTCTTGCTC TCCTTCCTCC TCCGCCTCCT CAGCTCTTGG 60
GCTAGAATAT CTATGGGTCG AAACGTGATG CGATGAATCC GAGAGAGACC GAAACTGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

mmu:382236

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001881	Ailuropoda melanoleuca	94.78	0.00e+00	3079.00
IUUC-Apl-004016	Anas platyrhynchos	79.74	0.00e+00	2251.00
IUUC-Aca-004722	Anolis carolinensis	78.48	0.00e+00	2197.00
IUUC-Ame-010602	Astyanax mexicanus	76.92	0.00e+00	1147.00
IUUC-Bta-013198	Bos taurus	93.43	0.00e+00	2804.00
IUUC-Cfa-020963	Canis familiaris	94.56	0.00e+00	3067.00
IUUC-Cpo-022448	Cavia porcellus	87.85	0.00e+00	2774.00
IUUC-Csa-023166	Chlorocebus sabaeus	94.52	0.00e+00	2919.00
IUUC-Cin-025553	Ciona intestinalis	39.34	6.00e-112	398.00
IUUC-Csv-025813	Ciona savignyi	43.69	0.00e+00	649.00
IUUC-Dre-028508	Danio rerio	66.20	0.00e+00	1887.00
IUUC-Dno-030070	Dasypus novemcinctus	91.51	0.00e+00	2952.00
IUUC-Dor-031052	Dipodomys ordii	88.90	0.00e+00	1169.00
IUUC-Ete-032650	Echinops telfairi	84.81	0.00e+00	1808.00
IUUC-Eca-033953	Equus caballus	94.54	0.00e+00	2743.00
IUUC-Eeu-034871	Erinaceus europaeus	82.23	0.00e+00	1340.00
IUUC-Fca-036099	Felis catus	94.45	0.00e+00	3066.00
IUUC-Fal-037246	Ficedula albicollis	81.96	0.00e+00	2414.00
IUUC-Gga-041097	Gallus gallus	82.84	0.00e+00	2518.00
IUUC-Gac-042435	Gasterosteus aculeatus	65.29	0.00e+00	1845.00
IUUC-Hsa-045666	Homo sapiens	94.46	0.00e+00	2921.00
IUUC-Loc-051802	Lepisosteus oculatus	69.90	0.00e+00	2081.00
IUUC-Laf-053942	Loxodonta africana	94.39	0.00e+00	2958.00
IUUC-Mcc-054645	Macaca mulatta	94.64	0.00e+00	2924.00
IUUC-Meu-056321	Macropus eugenii	76.10	0.00e+00	1110.00
IUUC-Mga-060063	Meleagris gallopavo	82.76	0.00e+00	2472.00
IUUC-Mmr-061262	Microcebus murinus	94.39	0.00e+00	2924.00
IUUC-Mdo-062320	Monodelphis domestica	74.41	0.00e+00	2264.00
IUUC-Mpu-066628	Mustela putorius furo	94.33	0.00e+00	3091.00
IUUC-Mlu-068082	Myotis lucifugus	94.40	0.00e+00	2880.00
IUUC-Nle-069609	Nomascus leucogenys	94.52	0.00e+00	2928.00
IUUC-Ont-071589	Oreochromis niloticus	66.44	0.00e+00	1819.00
IUUC-Ocu-074122	Oryctolagus cuniculus	92.53	0.00e+00	2069.00
IUUC-Oni-082991	Oryza nivara	28.17	3.00e-43	171.00
IUUC-Ola-086580	Oryzias latipes	66.16	0.00e+00	1883.00
IUUC-Oga-089053	Otolemur garnettii	93.89	0.00e+00	3053.00
IUUC-Oar-090042	Ovis aries	94.17	0.00e+00	3082.00
IUUC-Ptr-091268	Pan troglodytes	93.55	0.00e+00	2870.00
IUUC-Pan-092376	Papio anubis	94.58	0.00e+00	2922.00
IUUC-Psi-093408	Pelodiscus sinensis	81.37	0.00e+00	2509.00
IUUC-Pfo-096515	Poecilia formosa	66.25	0.00e+00	1778.00
IUUC-Pab-097672	Pongo abelii	92.47	0.00e+00	2904.00
IUUC-Pva-102512	Pteropus vampyrus	96.50	0.00e+00	2323.00
IUUC-Rno-105797	Rattus norvegicus	97.71	0.00e+00	3001.00
IUUC-Sha-107061	Sarcophilus harrisii	76.04	0.00e+00	2263.00
IUUC-Sit-110017	Setaria italica	28.85	1.00e-56	215.00
IUUC-Sar-113004	Sorex araneus	82.43	0.00e+00	1592.00
IUUC-Tgu-117254	Taeniopygia guttata	82.25	0.00e+00	2420.00
IUUC-Tru-118186	Takifugu rubripes	66.05	0.00e+00	1835.00
IUUC-Tsy-119003	Tarsius syrichta	88.17	0.00e+00	2689.00
IUUC-Tni-120110	Tetraodon nigroviridis	65.84	0.00e+00	1807.00
IUUC-Tbe-127813	Tupaia belangeri	74.86	0.00e+00	879.00
IUUC-Ttr-129265	Tursiops truncatus	90.84	0.00e+00	2787.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence