iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118186

Ensembl Protein ID

ENSTRUP00000034294.1

UniProt Accession

H2UBH6; H2UBH6_TAKRU

Protein Name

Uncharacterized protein

Gene Name

brwd3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000013452.1	ENSTRUT00000034420.1	ENSTRUP00000034294.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.00e-28	97.9	364	397
UBD/Beta-Prp	3.10e-49	169.0	282	541

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sd.tllvsGsdDgtikvWDlr 31
           Htd+v  ++f   sd  ++vsGs+Dgt+++W++ 
   Q: 364  HTDKVVVVQFsnnSDsLRFVSGSRDGTVRIWRYQ 397
           ***********9877788*************975 PP

UBD/Beta-Prp

   S: 21   dksllatgsrdgtikvwdvttgkl......lrslsgheae..........vtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlk 91
            +++l ++++dg++  w++++ ++      +        +          v++ +fs+ g +++tgs+D++i+v+    +t+  v  + 
   Q: 282  TTRYLGSTGADGMVCFWKFHSVSMkfddqpV--------KfversrpgvqVSTSSFSSGGMFMATGSTDHMIRVYylGAETPMKVAEMD 362
           678999999**********996665555553........1444444456689999********************77788999999999 PP
   S: 92   ghedsvlslsfspsg..dklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrl 163
           +h+d+v+ ++fs ++   ++vsGs+d t+r+w  +++++                   +++++ vv++v+++  ++ ++++  +  +++
   Q: 363  AHTDKVVVVQFSNNSdsLRFVSGSRDGTVRIWRYQQQEWKGIsldmaaklpgntvanSDDKTKLVVTMVAWDRADSTVITAVSNYLLKV 451
           *************5523689************99999999889************99999999************************** PP
   S: 164  Wdlktgkllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDg 244
           W++ tg+ll+ l+g h+d v  ++   fds  + ++s+++dg + +wdl +g  +r + +         + + +fs ++++++++ s+g
   Q: 452  WRSTTGQLLHVLSG-HDDEVFVMEahpFDS--RIILSAGHDGNIYMWDLTKGAKIRNFFNMIegqghGAIFDCKFSADGQHFACTDSHG 537
           *************9.*********655555..9*******************9988876644334444555567777777777777777 PP
   S: 245  siri 248
            + i
   Q: 538  HLLI 541
           7766 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MEREQCSQIE AELYYLIARF LQSGPCKKAA QILIEELEEY ELVPERWTWD GQKYKRTFQD 60
WMIVNEHIPA DYLLRVCQRI GPLIEKEVPP SVPGVQTLLG LGKQSLLRTS KSCSHKVCSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAAGAG AACAGTGTTC ACAAATCGAG GCCGGTGAGT TACGAGCATG CATTTTTGTA 60
GAAATAACAT TGCAGAGTTA GCATAATGCT AAGTTAAAGA GCTAATCCTA GCTCGGGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001487--Bromodomain
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001881	Ailuropoda melanoleuca	65.98	0.00e+00	1901.00
IUUC-Apl-004016	Anas platyrhynchos	63.24	0.00e+00	1748.00
IUUC-Aca-004722	Anolis carolinensis	65.96	0.00e+00	1688.00
IUUC-Ame-010602	Astyanax mexicanus	70.80	0.00e+00	1960.00
IUUC-Bta-013198	Bos taurus	66.26	0.00e+00	1757.00
IUUC-Cfa-020963	Canis familiaris	66.11	0.00e+00	1900.00
IUUC-Cpo-022448	Cavia porcellus	62.23	0.00e+00	1789.00
IUUC-Csa-023166	Chlorocebus sabaeus	65.47	0.00e+00	1905.00
IUUC-Dre-028508	Danio rerio	69.49	0.00e+00	2001.00
IUUC-Dno-030070	Dasypus novemcinctus	64.06	0.00e+00	1818.00
IUUC-Ete-032650	Echinops telfairi	60.46	0.00e+00	1282.00
IUUC-Eca-033953	Equus caballus	67.01	0.00e+00	1721.00
IUUC-Eeu-034871	Erinaceus europaeus	59.90	0.00e+00	942.00
IUUC-Fca-036099	Felis catus	65.95	0.00e+00	1897.00
IUUC-Fal-037246	Ficedula albicollis	66.79	0.00e+00	1833.00
IUUC-Gmo-039116	Gadus morhua	84.50	3.00e-155	543.00
IUUC-Gga-041097	Gallus gallus	65.96	0.00e+00	1875.00
IUUC-Gac-042435	Gasterosteus aculeatus	78.63	0.00e+00	2351.00
IUUC-Hsa-045666	Homo sapiens	65.47	0.00e+00	1907.00
IUUC-Lch-050646	Latimeria chalumnae	57.17	0.00e+00	1651.00
IUUC-Loc-051802	Lepisosteus oculatus	70.65	0.00e+00	2054.00
IUUC-Laf-053942	Loxodonta africana	65.88	0.00e+00	1916.00
IUUC-Mcc-054645	Macaca mulatta	65.54	0.00e+00	1909.00
IUUC-Meu-056321	Macropus eugenii	58.38	0.00e+00	859.00
IUUC-Mga-060063	Meleagris gallopavo	66.67	0.00e+00	1857.00
IUUC-Mmr-061262	Microcebus murinus	65.72	0.00e+00	1917.00
IUUC-Mdo-062320	Monodelphis domestica	61.03	0.00e+00	1709.00
IUUC-Mmu-063163	Mus musculus	65.88	0.00e+00	1895.00
IUUC-Mpu-066628	Mustela putorius furo	65.91	0.00e+00	1892.00
IUUC-Mlu-068082	Myotis lucifugus	66.85	0.00e+00	1886.00
IUUC-Nle-069609	Nomascus leucogenys	65.40	0.00e+00	1907.00
IUUC-Ont-071589	Oreochromis niloticus	82.06	0.00e+00	2363.00
IUUC-Oan-072954	Ornithorhynchus anatinus	56.18	0.00e+00	1625.00
IUUC-Ogu-078641	Oryza glumaepatula	28.74	9.00e-38	153.00
IUUC-Oni-082991	Oryza nivara	28.74	6.00e-38	153.00
IUUC-Ola-086580	Oryzias latipes	76.06	0.00e+00	2348.00
IUUC-Oga-089053	Otolemur garnettii	65.84	0.00e+00	1901.00
IUUC-Oar-090042	Ovis aries	66.25	0.00e+00	1904.00
IUUC-Ptr-091268	Pan troglodytes	65.06	0.00e+00	1876.00
IUUC-Pan-092376	Papio anubis	65.54	0.00e+00	1909.00
IUUC-Psi-093408	Pelodiscus sinensis	66.52	0.00e+00	1863.00
IUUC-Pfo-096515	Poecilia formosa	75.06	0.00e+00	2279.00
IUUC-Pab-097672	Pongo abelii	64.16	0.00e+00	1873.00
IUUC-Pva-102512	Pteropus vampyrus	67.85	0.00e+00	1657.00
IUUC-Rno-105797	Rattus norvegicus	66.00	0.00e+00	1912.00
IUUC-Sha-107061	Sarcophilus harrisii	63.41	0.00e+00	1738.00
IUUC-Sar-113004	Sorex araneus	73.13	0.00e+00	842.00
IUUC-Tgu-117254	Taeniopygia guttata	66.64	0.00e+00	1835.00
IUUC-Tsy-119003	Tarsius syrichta	60.95	0.00e+00	1701.00
IUUC-Tni-120110	Tetraodon nigroviridis	86.88	0.00e+00	2709.00
IUUC-Ttr-129265	Tursiops truncatus	65.77	0.00e+00	1853.00
IUUC-Xtr-132717	Xenopus tropicalis	56.05	0.00e+00	1630.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence