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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046495
UUCD1 version UUC-HoS-00190
Ensembl Protein ID ENSP00000298097.7
UniProt Accession Q7Z6M2; Q6PIR2; Q86TR2; Q86YE0; FBX33_HUMAN
Genbank Protein ID AAH42535.1; AAH53537.1; AAH68566.1; CAD66579.1
Protein Name F-box only protein 33
Genbank Nucleotide ID BC030611; BC053537; BC068566; BX248772
Gene Name FBXO33; FBX33
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000165355.7 ENST00000298097.7 ENSP00000298097.7
ENSG00000165355.7 ENST00000554190.1 ENSP00000451277.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 16797541
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00057 21.6 68 111
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 103  ldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
             +lp e++v+i+++l++++ lra+  c +w+e+   +alw ++
   Q: 68   AASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQL 111
           5789****************************999999999765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
Protein Sequence
(Fasta)
MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG AGSRRRGRMA 60
LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE CLFYPALWPQ LRICLRVSPA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046495|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTTCCGGAA GTCGCGCCGG TGCGCGCCGG ACTCCTCCCA CCAGCGGCGA CGTCAAACTC 60
AGCTCCTACC ACTTCTCTGT CTCTGCCGAC CGGCGCAGGG AGGGCTGCCT TTTCCTTACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046495|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
Gene Ontology

GO:0016567--P:protein ubiquitination
KEGG hsa:254170
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000943 Aegilops tauschii 50.00 3.00e-04 40.00
IUUC-Aml-001877 Ailuropoda melanoleuca 96.20 0.00e+00 967.00
IUUC-Apl-003462 Anas platyrhynchos 89.92 0.00e+00 639.00
IUUC-Aca-004463 Anolis carolinensis 82.25 0.00e+00 816.00
IUUC-Ang-009718 Aspergillus niger 33.90 5.00e-03 35.00
IUUC-Ame-011827 Astyanax mexicanus 51.21 5.00e-110 390.00
IUUC-Bgr-012240 Blumeria graminis 33.87 2.50e-02 32.30
IUUC-Bta-013535 Bos taurus 94.42 0.00e+00 917.00
IUUC-Bdi-014513 Brachypodium distachyon 39.62 2.00e-03 37.00
IUUC-Cja-019596 Callithrix jacchus 95.34 0.00e+00 987.00
IUUC-Cfa-021277 Canis familiaris 95.98 0.00e+00 962.00
IUUC-Cpo-022210 Cavia porcellus 94.94 0.00e+00 678.00
IUUC-Csa-023690 Chlorocebus sabaeus 99.01 0.00e+00 991.00
IUUC-Cho-024460 Choloepus hoffmanni 87.62 0.00e+00 854.00
IUUC-Dre-028632 Danio rerio 57.26 3.00e-153 535.00
IUUC-Dno-029088 Dasypus novemcinctus 61.08 2.00e-163 569.00
IUUC-Dor-031137 Dipodomys ordii 87.90 5.00e-134 471.00
IUUC-Dme-031612 Drosophila melanogaster 23.01 1.00e-15 78.20
IUUC-Ete-033103 Echinops telfairi 85.29 0.00e+00 829.00
IUUC-Eca-033741 Equus caballus 97.30 8.00e-172 595.00
IUUC-Eeu-034753 Erinaceus europaeus 92.96 0.00e+00 669.00
IUUC-Fca-036491 Felis catus 96.36 0.00e+00 904.00
IUUC-Fal-036634 Ficedula albicollis 76.75 0.00e+00 743.00
IUUC-Gmo-039489 Gadus morhua 52.87 5.00e-135 474.00
IUUC-Gga-040605 Gallus gallus 85.51 0.00e+00 803.00
IUUC-Gac-041591 Gasterosteus aculeatus 53.59 2.00e-142 498.00
IUUC-Ggo-045512 Gorilla gorilla 99.60 0.00e+00 978.00
IUUC-Hvu-047454 Hordeum vulgare 50.00 5.00e-05 39.30
IUUC-Itr-048674 Ictidomys tridecemlineatus 95.09 0.00e+00 795.00
IUUC-Lch-049834 Latimeria chalumnae 67.31 0.00e+00 667.00
IUUC-Loc-052593 Lepisosteus oculatus 60.56 9.00e-160 556.00
IUUC-Laf-053475 Loxodonta africana 95.37 0.00e+00 949.00
IUUC-Mcc-055139 Macaca mulatta 98.79 0.00e+00 969.00
IUUC-Meu-056055 Macropus eugenii 91.75 0.00e+00 905.00
IUUC-Mga-059806 Meleagris gallopavo 90.54 5.00e-151 526.00
IUUC-Mmr-061794 Microcebus murinus 91.13 0.00e+00 871.00
IUUC-Mdo-062916 Monodelphis domestica 82.53 0.00e+00 921.00
IUUC-Mmu-063461 Mus musculus 91.85 0.00e+00 931.00
IUUC-Mpu-066517 Mustela putorius furo 95.84 0.00e+00 877.00
IUUC-Mlu-067120 Myotis lucifugus 88.20 0.00e+00 886.00
IUUC-Nle-069732 Nomascus leucogenys 99.60 0.00e+00 978.00
IUUC-Opr-070666 Ochotona princeps 93.40 7.00e-157 546.00
IUUC-Ont-072460 Oreochromis niloticus 54.98 1.00e-148 519.00
IUUC-Oan-073282 Ornithorhynchus anatinus 81.62 0.00e+00 769.00
IUUC-Ocu-074658 Oryctolagus cuniculus 90.11 0.00e+00 889.00
IUUC-Oba-075550 Oryza barthii 51.72 1.20e-02 35.80
IUUC-Obr-076082 Oryza brachyantha 50.00 4.00e-04 39.30
IUUC-Ogu-078346 Oryza glumaepatula 51.72 1.20e-02 35.80
IUUC-Olo-080845 Oryza longistaminata 48.48 9.00e-03 36.60
IUUC-Osa-086103 Oryza sativa 37.84 5.00e-04 36.60
IUUC-Ola-086741 Oryzias latipes 53.80 2.00e-145 509.00
IUUC-Olu-087736 Ostreococcus lucimarinus 37.50 3.30e-02 33.50
IUUC-Oga-088461 Otolemur garnettii 96.98 0.00e+00 957.00
IUUC-Oar-089213 Ovis aries 90.36 0.00e+00 885.00
IUUC-Ptr-091577 Pan troglodytes 99.60 0.00e+00 978.00
IUUC-Pan-092148 Papio anubis 98.81 0.00e+00 989.00
IUUC-Psi-093066 Pelodiscus sinensis 89.54 0.00e+00 700.00
IUUC-Pma-094652 Petromyzon marinus 42.65 8.00e-54 204.00
IUUC-Pno-095074 Phaeosphaeria nodorum 25.51 6.00e-02 32.30
IUUC-Pfo-097380 Poecilia formosa 51.49 3.00e-133 468.00
IUUC-Pab-098714 Pongo abelii 99.20 0.00e+00 972.00
IUUC-Pop-099249 Populus trichocarpa 59.38 5.00e-04 38.90
IUUC-Pca-100421 Procavia capensis 94.65 0.00e+00 676.00
IUUC-Pva-102197 Pteropus vampyrus 89.88 2.00e-161 561.00
IUUC-Rno-105524 Rattus norvegicus 89.34 0.00e+00 894.00
IUUC-Sha-106909 Sarcophilus harrisii 91.55 2.00e-162 564.00
IUUC-Sit-110207 Setaria italica 42.86 3.00e-04 40.00
IUUC-Sar-113735 Sorex araneus 97.75 0.00e+00 707.00
IUUC-Ssc-116029 Sus scrofa 95.78 0.00e+00 924.00
IUUC-Tgu-117400 Taeniopygia guttata 84.10 0.00e+00 826.00
IUUC-Tru-118167 Takifugu rubripes 52.99 2.00e-140 492.00
IUUC-Tsy-119021 Tarsius syrichta 98.31 0.00e+00 718.00
IUUC-Tni-119925 Tetraodon nigroviridis 52.39 2.00e-142 499.00
IUUC-Tvi-122433 Trichoderma virens 36.96 1.00e-03 37.70
IUUC-Tae-124888 Triticum aestivum 50.00 4.00e-04 39.70
IUUC-Tur-126603 Triticum urartu 37.84 2.00e-03 37.40
IUUC-Tbe-127569 Tupaia belangeri 97.37 0.00e+00 759.00
IUUC-Ttr-128479 Tursiops truncatus 97.75 0.00e+00 716.00
IUUC-Vpa-130116 Vicugna pacos 98.03 0.00e+00 713.00
IUUC-Vvi-131186 Vitis vinifera 48.72 2.00e-04 40.00
IUUC-Xtr-132849 Xenopus tropicalis 77.03 0.00e+00 803.00
Created Date 25-Jun-2017

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