iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165501.16	ENST00000298288.10	ENSP00000298288.6
ENSG00000165501.16	ENST00000318317.8	ENSP00000315628.4
ENSG00000165501.16	ENST00000554869.5	ENSP00000452355.1
ENSG00000165501.16	ENST00000540712.1	ENSP00000439452.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	21074711; 23555289

Organism

Homo sapiens

Functional Description
(View)

May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MKLHCEVEVI SRHLPALGLR NRGKGVRAVL SLCQQTSRSQ PPVRAFLLIS TLKDKRGTRY 60
ELRENIEQFF TKFVDEGKAT VRLKEPPVDI CLSKAISSSL KGFLSAMRLA HRGCNVDTPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACCACCGCT GCCAGCTGCG CGCTCGGGGG AAAAGACGTT GCGCCCCCGC CGACTGCCGG 60
TTTCCCGGGC GCGAGCCCGG ATCCAGGTGG TCAGTCCCGG TACGCAACCA CGGCGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR025875--Leu-rich_rpt_4
IPR003591--Leu-rich_rpt_typical-subtyp

PROSITE

PS51450--LRR

Pfam

PF12799--LRR_4
PF13516--LRR_6

SMART

SM00369--LRR_TYP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0016567--P:protein ubiquitination
GO:0007165--P:signal transduction

KEGG

hsa:122769

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001780	Ailuropoda melanoleuca	85.61	0.00e+00	744.00
IUUC-Atr-002772	Amborella trichopoda	38.05	6.00e-10	58.20
IUUC-Apl-003947	Anas platyrhynchos	72.54	3.00e-97	347.00
IUUC-Aca-004845	Anolis carolinensis	66.83	3.00e-142	498.00
IUUC-Ame-011571	Astyanax mexicanus	63.73	7.00e-138	483.00
IUUC-Bta-013510	Bos taurus	87.74	0.00e+00	742.00
IUUC-Cel-018313	Caenorhabditis elegans	26.90	1.00e-13	71.20
IUUC-Cja-019616	Callithrix jacchus	92.75	0.00e+00	785.00
IUUC-Cfa-020085	Canis familiaris	85.07	0.00e+00	732.00
IUUC-Cpo-022006	Cavia porcellus	82.06	0.00e+00	651.00
IUUC-Csa-023376	Chlorocebus sabaeus	95.89	0.00e+00	816.00
IUUC-Cho-024851	Choloepus hoffmanni	87.92	0.00e+00	696.00
IUUC-Csv-025951	Ciona savignyi	39.57	2.00e-78	286.00
IUUC-Dre-028231	Danio rerio	52.42	4.00e-48	184.00
IUUC-Dno-029840	Dasypus novemcinctus	86.35	0.00e+00	733.00
IUUC-Dor-030722	Dipodomys ordii	84.54	0.00e+00	721.00
IUUC-Dme-031624	Drosophila melanogaster	29.92	3.00e-30	126.00
IUUC-Ete-032265	Echinops telfairi	85.27	0.00e+00	731.00
IUUC-Eca-034050	Equus caballus	90.40	0.00e+00	657.00
IUUC-Eeu-034807	Erinaceus europaeus	75.84	3.00e-173	601.00
IUUC-Fca-035883	Felis catus	86.35	0.00e+00	736.00
IUUC-Fal-037470	Ficedula albicollis	66.57	4.00e-122	431.00
IUUC-Gmo-039145	Gadus morhua	58.82	1.00e-138	486.00
IUUC-Gga-040580	Gallus gallus	68.87	7.00e-150	523.00
IUUC-Gac-041408	Gasterosteus aculeatus	59.07	2.00e-137	482.00
IUUC-Ggo-044999	Gorilla gorilla	99.52	0.00e+00	838.00
IUUC-Itr-048389	Ictidomys tridecemlineatus	85.18	0.00e+00	733.00
IUUC-Lch-049921	Latimeria chalumnae	69.61	1.00e-156	546.00
IUUC-Loc-052946	Lepisosteus oculatus	62.75	3.00e-135	474.00
IUUC-Laf-053665	Loxodonta africana	88.44	0.00e+00	747.00
IUUC-Mcc-055451	Macaca mulatta	96.14	0.00e+00	817.00
IUUC-Meu-056760	Macropus eugenii	74.26	5.00e-94	337.00
IUUC-Mga-059693	Meleagris gallopavo	71.11	6.00e-117	413.00
IUUC-Mmr-061640	Microcebus murinus	87.44	0.00e+00	729.00
IUUC-Mdo-062013	Monodelphis domestica	74.94	9.00e-161	559.00
IUUC-Mmu-064208	Mus musculus	77.43	3.00e-175	607.00
IUUC-Mpu-066695	Mustela putorius furo	83.77	2.00e-169	588.00
IUUC-Mlu-067598	Myotis lucifugus	84.47	0.00e+00	715.00
IUUC-Nle-069282	Nomascus leucogenys	98.07	0.00e+00	804.00
IUUC-Opr-070622	Ochotona princeps	82.21	0.00e+00	656.00
IUUC-Ont-072349	Oreochromis niloticus	59.31	3.00e-136	478.00
IUUC-Oan-073270	Ornithorhynchus anatinus	77.59	1.00e-136	479.00
IUUC-Ocu-074328	Oryctolagus cuniculus	89.02	0.00e+00	745.00
IUUC-Ome-081910	Oryza meridionalis	32.03	1.00e-10	61.60
IUUC-Ola-087391	Oryzias latipes	58.80	6.00e-141	493.00
IUUC-Oga-088088	Otolemur garnettii	85.40	0.00e+00	714.00
IUUC-Oar-089741	Ovis aries	86.32	0.00e+00	687.00
IUUC-Ptr-091019	Pan troglodytes	99.52	0.00e+00	839.00
IUUC-Pan-092495	Papio anubis	96.38	0.00e+00	818.00
IUUC-Psi-092946	Pelodiscus sinensis	77.41	1.00e-104	372.00
IUUC-Pma-094443	Petromyzon marinus	44.98	9.00e-81	294.00
IUUC-Pfo-096494	Poecilia formosa	58.09	3.00e-135	475.00
IUUC-Pab-097847	Pongo abelii	97.34	0.00e+00	823.00
IUUC-Pva-103223	Pteropus vampyrus	90.10	0.00e+00	736.00
IUUC-Rno-105407	Rattus norvegicus	77.73	3.00e-172	597.00
IUUC-Sha-106939	Sarcophilus harrisii	77.01	1.00e-145	509.00
IUUC-Sly-111052	Solanum lycopersicum	31.65	1.00e-16	80.50
IUUC-Sar-113321	Sorex araneus	78.50	2.00e-179	622.00
IUUC-Ssc-116378	Sus scrofa	90.97	1.00e-138	485.00
IUUC-Tgu-117441	Taeniopygia guttata	66.77	6.00e-112	397.00
IUUC-Tru-118303	Takifugu rubripes	59.56	1.00e-130	459.00
IUUC-Tsy-119397	Tarsius syrichta	87.00	6.00e-112	397.00
IUUC-Tni-120292	Tetraodon nigroviridis	58.35	1.00e-136	479.00
IUUC-Tbe-128087	Tupaia belangeri	86.53	7.00e-166	576.00
IUUC-Ttr-128489	Tursiops truncatus	87.65	0.00e+00	737.00
IUUC-Vpa-130640	Vicugna pacos	77.54	0.00e+00	630.00
IUUC-Xtr-132352	Xenopus tropicalis	63.48	1.00e-142	499.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence