iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064096

UUCD1 version

UUC-MuM-00020

Ensembl Protein ID

ENSMUSP00000070728.5

UniProt Accession

Q3ULA2; Q3U0Q4; Q571K6; Q9QUI5; Q9R1G7; Q9Z159; FBW1A_MOUSE

Genbank Protein ID

AAD08701.1; AAD41025.1; AAD04181.1; AAD17755.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; AAL40929.1; BAE26547.1; BAE33798.1; BAD90368.1; EDL41951.1; AAH03989.1

Protein Name

F-box/WD repeat-containing protein 1A; Beta-TrCP protein E3RS-IkappaB; Beta-transducin repeat-containing protein; E3RSIkappaB; F-box and WD repeats protein beta-TrCP; HOS; Ubiquitin ligase FWD1; pIkappaB-E3 receptor subunit

Genbank Nucleotide ID

AF099932; AF110396; AF112979; AF081887; AF391190; AF391178; AF391179; AF391180; AF391181; AF391182; AF391183; AF391184; AF391185; AF391186; AF391187; AF391188; AF391189; AK145624; AK156660; AK220183; CH466534; BC003989

Gene Name

Btrc; Fbw1; Fbxw1; Fwd1; Kiaa4123

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000025217.14	ENSMUST00000065601.11	ENSMUSP00000070728.5
ENSMUSG00000025217.14	ENSMUST00000111936.2	ENSMUSP00000107567.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	16611981; 15767683
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	16611981; 15767683; 17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00065	20.9	191	228
E3 adaptor/Cullin RING/DCX/DWD	3.90e-58	191.9	504	537
UBD/Beta-Prp	3.00e-68	231.3	418	582

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 109  eilveilklldkeellraarvcrrwqelasqkalwktv 146
           +i  +il++ld+++l++a++vc++w++++s+  lwk++
   Q: 191  HIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 228
           7899**************************9****987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgv 34
           gH++ v+c++f d +++vsG++Dg+ikvWDl    
   Q: 504  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLMAAL 537
           8**********.44****************97665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 418  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 501
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+
   Q: 502  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLmaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDF 582
           **************9..*************************877889****98.************..99**************7 PP

Organism

Mus musculus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Protein Sequence
(Fasta)

MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC 60
NNGEPPRKII PEKNSLRQTY NSCARLCINQ ETVCLTSTAM KTENCVAKAK LANGTSSMIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGGGGGA AGGAAGAGGA GGCGGGATCC GGACGCTGCG TTGGCTGCGG CCTGGCACGA 60
AAGGGGCGGC CCCGGCGGAG AGCAGACCCA GTAGTCCGGG CGATTATGGA CCCGGCAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0008013--F:beta-catenin binding
GO:0045309--F:protein phosphorylated amino acid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0071407--P:cellular response to organic cyclic compound
GO:0007623--P:circadian rhythm
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030163--P:protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0042752--P:regulation of circadian rhythm
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:12234

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	98.68	0.00e+00	1249.00
IUUC-Apl-003437	Anas platyrhynchos	97.80	0.00e+00	1015.00
IUUC-Aca-004410	Anolis carolinensis	91.72	0.00e+00	1195.00
IUUC-Acl-008355	Aspergillus clavatus	29.76	2.00e-50	194.00
IUUC-Afl-008580	Aspergillus flavus	27.92	4.00e-44	172.00
IUUC-Afu-008790	Aspergillus fumigatus	29.79	2.00e-38	154.00
IUUC-Ani-009324	Aspergillus nidulans	29.40	2.00e-48	187.00
IUUC-Aor-009916	Aspergillus oryzae	28.88	3.00e-47	183.00
IUUC-Ate-010492	Aspergillus terreus	29.53	1.00e-49	191.00
IUUC-Bgr-012194	Blumeria graminis	32.52	4.00e-54	206.00
IUUC-Bta-013453	Bos taurus	92.73	0.00e+00	1155.00
IUUC-Bci-013685	Botrytis cinerea	31.51	8.00e-55	208.00
IUUC-Cja-019121	Callithrix jacchus	94.05	0.00e+00	1176.00
IUUC-Cfa-020553	Canis familiaris	98.84	0.00e+00	1250.00
IUUC-Cpo-022126	Cavia porcellus	96.13	0.00e+00	1158.00
IUUC-Csa-023688	Chlorocebus sabaeus	98.68	0.00e+00	1249.00
IUUC-Cin-025188	Ciona intestinalis	80.71	0.00e+00	828.00
IUUC-Csv-026020	Ciona savignyi	76.34	0.00e+00	788.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.26	2.00e-60	227.00
IUUC-Dno-029484	Dasypus novemcinctus	92.73	0.00e+00	1157.00
IUUC-Dor-031010	Dipodomys ordii	92.52	0.00e+00	1097.00
IUUC-Dse-031287	Dothistroma septosporum	28.91	3.00e-52	200.00
IUUC-Dme-031885	Drosophila melanogaster	77.98	0.00e+00	817.00
IUUC-Ete-032978	Echinops telfairi	85.74	0.00e+00	1045.00
IUUC-Eca-033374	Equus caballus	97.81	0.00e+00	1213.00
IUUC-Eeu-034760	Erinaceus europaeus	77.52	0.00e+00	937.00
IUUC-Fca-035427	Felis catus	94.55	0.00e+00	1182.00
IUUC-Fal-037530	Ficedula albicollis	97.79	0.00e+00	1202.00
IUUC-Fox-037978	Fusarium oxysporum	33.77	7.00e-63	235.00
IUUC-Fso-038077	Fusarium solani	32.97	1.00e-57	218.00
IUUC-Ggr-039974	Gaeumannomyces graminis	32.30	3.00e-56	213.00
IUUC-Gga-041087	Gallus gallus	94.27	0.00e+00	1222.00
IUUC-Ggo-045369	Gorilla gorilla	98.19	0.00e+00	1139.00
IUUC-Hsa-045962	Homo sapiens	98.68	0.00e+00	1249.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	98.90	0.00e+00	934.00
IUUC-Lch-050285	Latimeria chalumnae	88.98	0.00e+00	933.00
IUUC-Loc-052686	Lepisosteus oculatus	91.57	0.00e+00	1159.00
IUUC-Lma-053289	Leptosphaeria maculans	38.08	2.00e-47	184.00
IUUC-Laf-054022	Loxodonta africana	97.81	0.00e+00	1214.00
IUUC-Mcc-055782	Macaca mulatta	98.64	0.00e+00	1211.00
IUUC-Meu-056078	Macropus eugenii	83.84	0.00e+00	891.00
IUUC-Mor-057283	Magnaporthe oryzae	33.26	9.00e-59	221.00
IUUC-Mpo-057540	Magnaporthe poae	32.52	1.00e-56	215.00
IUUC-Mla-058989	Melampsora laricipopulina	40.57	9.00e-61	226.00
IUUC-Mga-059388	Meleagris gallopavo	96.50	0.00e+00	1209.00
IUUC-Mmr-060969	Microcebus murinus	98.84	0.00e+00	1250.00
IUUC-Mdo-063041	Monodelphis domestica	98.18	0.00e+00	1212.00
IUUC-Mpu-066875	Mustela putorius furo	98.73	0.00e+00	1140.00
IUUC-Mlu-067621	Myotis lucifugus	98.21	0.00e+00	1028.00
IUUC-Nfi-068263	Neosartorya fischeri	29.50	9.00e-50	191.00
IUUC-Ncr-068639	Neurospora crassa	34.54	1.00e-44	175.00
IUUC-Nle-069548	Nomascus leucogenys	98.51	0.00e+00	1248.00
IUUC-Opr-071194	Ochotona princeps	93.22	0.00e+00	1162.00
IUUC-Oan-072867	Ornithorhynchus anatinus	94.38	0.00e+00	1218.00
IUUC-Ocu-074246	Oryctolagus cuniculus	98.84	0.00e+00	1250.00
IUUC-Oga-088244	Otolemur garnettii	98.80	0.00e+00	1029.00
IUUC-Oar-089199	Ovis aries	98.23	0.00e+00	1039.00
IUUC-Ptr-090475	Pan troglodytes	78.88	0.00e+00	930.00
IUUC-Pan-092826	Papio anubis	98.68	0.00e+00	1249.00
IUUC-Psi-093485	Pelodiscus sinensis	94.61	0.00e+00	1169.00
IUUC-Pma-094315	Petromyzon marinus	79.71	0.00e+00	885.00
IUUC-Pab-097680	Pongo abelii	98.18	0.00e+00	1243.00
IUUC-Pca-100843	Procavia capensis	91.90	0.00e+00	1127.00
IUUC-Pva-102793	Pteropus vampyrus	88.76	0.00e+00	1088.00
IUUC-Pgr-103331	Puccinia graminis	37.69	2.00e-52	199.00
IUUC-Ptt-103853	Puccinia triticina	32.30	4.00e-61	228.00
IUUC-Pte-104392	Pyrenophora teres	37.01	5.00e-47	182.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	37.37	3.00e-47	184.00
IUUC-Rno-105304	Rattus norvegicus	99.49	0.00e+00	1221.00
IUUC-Sha-107454	Sarcophilus harrisii	93.69	0.00e+00	1195.00
IUUC-Sar-113471	Sorex araneus	77.85	0.00e+00	921.00
IUUC-Sre-114916	Sporisorium reilianum	34.08	9.00e-46	179.00
IUUC-Ssc-115490	Sus scrofa	99.01	0.00e+00	1046.00
IUUC-Tgu-117445	Taeniopygia guttata	97.69	0.00e+00	1234.00
IUUC-Tsy-118983	Tarsius syrichta	94.40	0.00e+00	1157.00
IUUC-Tre-122207	Trichoderma reesei	33.63	1.00e-55	211.00
IUUC-Tvi-122344	Trichoderma virens	33.63	1.00e-55	211.00
IUUC-Tme-127141	Tuber melanosporum	34.48	2.00e-64	240.00
IUUC-Tbe-128146	Tupaia belangeri	89.09	0.00e+00	1064.00
IUUC-Ttr-128946	Tursiops truncatus	98.68	0.00e+00	1249.00
IUUC-Uma-129491	Ustilago maydis	33.42	6.00e-47	182.00
IUUC-Vda-129941	Verticillium dahliae	32.59	2.00e-57	217.00
IUUC-Vpa-130709	Vicugna pacos	96.86	0.00e+00	1217.00
IUUC-Xtr-132861	Xenopus tropicalis	92.04	0.00e+00	1161.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence