• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP
  • Cancer Mutation
    • TCGA
    • ICGC
    • COSMIC
    • CGAP
    • IntOGen
  • SNP
    • dbSNP
  • mRNA Expression
    • GEO
    • ArrayExpress
    • TCGA
    • ICGC
    • COSMIC
    • THPA
    • HPM
  • DNA & RNA Element
    • UTRdb
    • AREsite
    • CircNet
    • miRTarBase
    • microRNA
    • TRANSFAC
    • miRecords
    • RepTar
    • miRcode
    • RAID2
  • PPI
    • IID
    • iRefIndex
    • PINA
    • HINT
    • Mentha
    • InWeb_IM
  • 3D Structure
    • PDB
    • MMDB
  • Disease
    • GWASdb
    • OMIM
  • Drug & target
    • TTD
    • GRAC
  • PTM
    • dbPAF
    • PhosphositePlus
    • dbPTM
    • HPRD
    • UniProt
  • DNA Methylation
    • TCGA
    • ICGC
    • COSMIC
  • Proteomics
    • THPA
    • HPM
    • GPMDB

Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046446
UUCD1 version UUC-HoS-01146
Ensembl Protein ID ENSP00000446057.2
UniProt Accession Q96LD8; Q96QA4; SENP8_HUMAN
Genbank Protein ID AAG21828.1; AAL06294.1; AAH31411.1
Protein Name Sentrin-specific protease 8; Deneddylase-1; NEDD8-specific protease 1; Protease, cysteine 2; Sentrin/SUMO-specific protease SENP8
Genbank Nucleotide ID AY008293; AF308450; BC031411
Gene Name SENP8; DEN1; NEDP1; PRSC2; FKSG8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000166192.14 ENST00000542035.2 ENSP00000446057.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRecordsRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 19784069
Classification
Family E-value Score Start End
DUB/ULP 7.60e-36 125.6 13 173
Active Site
Position(s) Description Evidence
163 Nucleophile N/A
Domain Profile

   DUB/ULP

   S: 3    vtnedlkcLeegeflnDviidfylkylvlekl..kkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpine.......aaH 85
    ++++d++ L+++++lnD+ii f ++y++++++ ++++v+ i++ +++f+k++++++ ++ ++++++dl +k+++f++in+ ++H
   Q: 13 LRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFhdCSDHVSFISPEVTQFIKCTSNPA--EIAMFLEPLDLPNKRVVFLAINDnsnqaagGTH 102
    7899****************************9999*******************99..9***************************988** PP
   S: 86 WslavvcfkkksilllDSlrgasksnvvkklreylev.evkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyves 163
    Wsl+v+ ++k+s++++DS+ + s+s +k+++e le +k++k +f +e k p Q+Ns+DCG+yv++++e+
   Q: 103 WSLLVYLQDKNSFFHYDSH-SRSNSVHAKQVAEKLEAfLGRKGDKLAFVEE-------KAPAQQNSYDCGMYVICNTEA 173
    *******************.56666666666666666555699*****994.......59****************997 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Protein Sequence
(Fasta)
MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ 60
FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046446|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTACTCCA ACAGCAGTCA AGAGAATGAA CAGGAGGGCA TGACAAGAGG CAGAAGACAG 60
AAGGCAAGAA GACCACTCAG CATTACAGAA GCCCAACAAA CAGATATTTT CAGTTAAAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046446|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0019784--F:NEDD8-specific protease activity
GO:0016929--F:SUMO-specific protease activity
GO:0016926--P:protein desumoylation
GO:0016579--P:protein deubiquitination

KEGG hsa:123228
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000648 Aegilops tauschii 36.89 5.00e-16 79.70
IUUC-Aml-001531 Ailuropoda melanoleuca 94.79 2.00e-119 421.00
IUUC-Atr-003013 Amborella trichopoda 33.33 5.00e-30 124.00
IUUC-Apl-004195 Anas platyrhynchos 76.42 6.00e-97 346.00
IUUC-Aca-004786 Anolis carolinensis 74.53 3.00e-87 314.00
IUUC-Aly-006071 Arabidopsis lyrata 32.40 3.00e-22 98.60
IUUC-Ath-006941 Arabidopsis thaliana 34.08 3.00e-24 105.00
IUUC-Acl-008184 Aspergillus clavatus 34.46 8.00e-15 73.90
IUUC-Afl-008691 Aspergillus flavus 35.29 3.00e-16 78.60
IUUC-Afu-008846 Aspergillus fumigatus 33.78 2.00e-14 72.80
IUUC-Ani-009338 Aspergillus nidulans 35.67 1.00e-15 76.60
IUUC-Ang-009621 Aspergillus niger 35.67 2.00e-17 82.80
IUUC-Aor-010058 Aspergillus oryzae 35.62 8.00e-15 74.30
IUUC-Ate-010257 Aspergillus terreus 37.27 2.00e-16 79.00
IUUC-Ame-011123 Astyanax mexicanus 63.68 7.00e-69 253.00
IUUC-Bgr-012027 Blumeria graminis 29.10 2.00e-14 73.20
IUUC-Bta-013318 Bos taurus 91.47 8.00e-109 385.00
IUUC-Bci-013780 Botrytis cinerea 38.18 3.00e-17 82.40
IUUC-Bdi-014628 Brachypodium distachyon 35.16 7.00e-18 84.00
IUUC-Bol-015265 Brassica oleracea 36.87 5.00e-29 120.00
IUUC-Bra-017473 Brassica rapa 35.75 2.00e-25 108.00
IUUC-Cel-018221 Caenorhabditis elegans 27.14 4.00e-19 87.80
IUUC-Cja-019384 Callithrix jacchus 95.75 1.00e-121 428.00
IUUC-Cfa-021012 Canis familiaris 95.73 1.00e-120 425.00
IUUC-Cpo-022076 Cavia porcellus 88.15 8.00e-113 399.00
IUUC-Cre-022914 Chlamydomonas reinhardtii 31.71 8.00e-20 90.90
IUUC-Csa-023063 Chlorocebus sabaeus 97.64 2.00e-123 434.00
IUUC-Cin-025409 Ciona intestinalis 45.20 7.00e-30 123.00
IUUC-Csv-025804 Ciona savignyi 42.86 5.00e-33 134.00
IUUC-Cgl-026720 Colletotrichum gloeosporioides 32.53 2.00e-13 69.70
IUUC-Dre-027976 Danio rerio 60.09 7.00e-70 256.00
IUUC-Dno-028918 Dasypus novemcinctus 91.94 2.00e-116 411.00
IUUC-Dor-030731 Dipodomys ordii 85.71 5.00e-106 376.00
IUUC-Dse-031309 Dothistroma septosporum 35.93 3.00e-17 82.40
IUUC-Dme-031655 Drosophila melanogaster 36.50 6.00e-34 137.00
IUUC-Eca-034335 Equus caballus 93.36 1.00e-118 418.00
IUUC-Fca-036443 Felis catus 94.79 1.00e-119 422.00
IUUC-Fal-037240 Ficedula albicollis 74.06 1.00e-93 335.00
IUUC-Fox-037732 Fusarium oxysporum 33.73 1.00e-14 73.90
IUUC-Fso-038212 Fusarium solani 33.73 1.00e-13 70.50
IUUC-Gmo-039320 Gadus morhua 61.06 1.00e-71 262.00
IUUC-Ggr-039866 Gaeumannomyces graminis 27.74 2.00e-08 52.80
IUUC-Gga-040846 Gallus gallus 76.42 1.00e-96 345.00
IUUC-Gac-041495 Gasterosteus aculeatus 60.85 3.00e-66 244.00
IUUC-Gma-043532 Glycine max 33.93 9.00e-30 123.00
IUUC-Ggo-045516 Gorilla gorilla 98.58 4.00e-125 439.00
IUUC-Hvu-047187 Hordeum vulgare 32.58 2.00e-20 92.80
IUUC-Itr-048831 Ictidomys tridecemlineatus 92.89 1.00e-116 411.00
IUUC-Kpa-049383 Komagataella pastoris 32.18 1.00e-15 77.40
IUUC-Lch-049930 Latimeria chalumnae 66.04 7.00e-84 303.00
IUUC-Lpe-051072 Leersia perrieri 35.75 2.00e-12 67.00
IUUC-Loc-052263 Lepisosteus oculatus 62.26 4.00e-75 273.00
IUUC-Lma-053175 Leptosphaeria maculans 35.83 1.00e-14 74.30
IUUC-Laf-053748 Loxodonta africana 93.40 2.00e-118 417.00
IUUC-Mcc-055121 Macaca mulatta 97.64 2.00e-123 434.00
IUUC-Mor-057015 Magnaporthe oryzae 30.12 4.00e-10 58.50
IUUC-Mpo-057551 Magnaporthe poae 29.75 1.00e-10 60.10
IUUC-Mtr-058308 Medicago truncatula 31.11 2.00e-27 115.00
IUUC-Mga-059787 Meleagris gallopavo 77.25 2.00e-90 324.00
IUUC-Mmr-061606 Microcebus murinus 92.42 4.00e-116 410.00
IUUC-Mdo-062222 Monodelphis domestica 83.96 3.00e-107 380.00
IUUC-Mmu-063494 Mus musculus 92.45 1.00e-117 415.00
IUUC-Mac-064771 Musa acuminata 34.71 2.00e-23 102.00
IUUC-Mpu-065843 Mustela putorius furo 94.79 4.00e-119 420.00
IUUC-Mlu-068110 Myotis lucifugus 94.79 8.00e-120 422.00
IUUC-Nfi-068584 Neosartorya fischeri 33.78 1.00e-14 72.80
IUUC-Ncr-068707 Neurospora crassa 32.53 3.00e-13 68.60
IUUC-Nle-069021 Nomascus leucogenys 98.11 2.00e-124 437.00
IUUC-Opr-070594 Ochotona princeps 83.89 6.00e-106 376.00
IUUC-Ont-072612 Oreochromis niloticus 64.15 4.00e-63 234.00
IUUC-Oan-073506 Ornithorhynchus anatinus 79.72 1.00e-94 338.00
IUUC-Ocu-074685 Oryctolagus cuniculus 89.10 3.00e-105 374.00
IUUC-Oba-075541 Oryza barthii 34.27 4.00e-13 69.30
IUUC-Obr-076358 Oryza brachyantha 29.41 3.00e-10 60.10
IUUC-Ogl-077166 Oryza glaberrima 32.98 2.00e-14 72.40
IUUC-Ogu-078617 Oryza glumaepatula 25.00 8.00e-06 45.80
IUUC-Oin-079763 Oryza indica 34.08 3.00e-14 72.00
IUUC-Olo-080606 Oryza longistaminata 34.64 5.00e-19 89.40
IUUC-Ome-081337 Oryza meridionalis 34.27 7.00e-13 68.90
IUUC-Oni-083102 Oryza nivara 34.27 7.00e-13 68.90
IUUC-Oru-084547 Oryza rufipogon 34.27 6.00e-14 72.40
IUUC-Osa-085591 Oryza sativa 34.08 3.00e-14 71.60
IUUC-Ola-087005 Oryzias latipes 62.26 2.00e-60 225.00
IUUC-Oga-088415 Otolemur garnettii 91.00 5.00e-116 409.00
IUUC-Oar-090151 Ovis aries 90.52 6.00e-114 402.00
IUUC-Ptr-091183 Pan troglodytes 99.06 1.00e-125 441.00
IUUC-Pan-092515 Papio anubis 97.63 6.00e-123 432.00
IUUC-Psi-093874 Pelodiscus sinensis 75.94 2.00e-97 348.00
IUUC-Pma-094504 Petromyzon marinus 46.58 6.00e-51 193.00
IUUC-Pno-094778 Phaeosphaeria nodorum 31.67 2.00e-12 65.90
IUUC-Ppa-095729 Physcomitrella patens 35.40 7.00e-30 124.00
IUUC-Pfo-097485 Poecilia formosa 65.09 2.00e-71 261.00
IUUC-Pab-098456 Pongo abelii 98.58 4.00e-125 439.00
IUUC-Pop-099754 Populus trichocarpa 33.19 9.00e-29 120.00
IUUC-Ppe-101897 Prunus persica 33.94 9.00e-31 126.00
IUUC-Pva-103087 Pteropus vampyrus 94.79 9.00e-119 419.00
IUUC-Pte-104338 Pyrenophora teres 32.94 3.00e-19 88.60
IUUC-Pyt-104743 Pyrenophora triticirepentis 30.38 2.00e-15 75.90
IUUC-Rno-105791 Rattus norvegicus 92.45 2.00e-117 414.00
IUUC-Sha-107481 Sarcophilus harrisii 83.49 6.00e-108 383.00
IUUC-Sja-107774 Schizosaccharomyces japonicus 29.95 1.00e-16 80.50
IUUC-Spo-108158 Schizosaccharomyces pombe 29.28 4.00e-13 69.30
IUUC-Sit-110301 Setaria italica 30.94 2.00e-18 85.90
IUUC-Sly-110870 Solanum lycopersicum 36.30 4.00e-18 84.00
IUUC-Stu-112872 Solanum tuberosum 34.86 3.00e-27 115.00
IUUC-Sar-113306 Sorex araneus 90.52 9.00e-115 405.00
IUUC-Sbi-113811 Sorghum bicolor 32.24 3.00e-13 70.10
IUUC-Sre-114940 Sporisorium reilianum 23.48 8.00e-10 57.40
IUUC-Ssc-116172 Sus scrofa 94.31 1.00e-118 418.00
IUUC-Tgu-117518 Taeniopygia guttata 74.53 9.00e-93 332.00
IUUC-Tru-118187 Takifugu rubripes 58.12 4.00e-59 221.00
IUUC-Tsy-119532 Tarsius syrichta 93.87 3.00e-118 417.00
IUUC-Tni-119854 Tetraodon nigroviridis 61.79 8.00e-62 229.00
IUUC-Tca-121178 Theobroma cacao 32.59 3.00e-28 118.00
IUUC-Tre-121875 Trichoderma reesei 33.13 3.00e-13 68.60
IUUC-Tvi-122665 Trichoderma virens 33.13 1.00e-14 73.20
IUUC-Tae-123260 Triticum aestivum 34.78 9.00e-21 94.00
IUUC-Tur-126065 Triticum urartu 33.68 2.00e-17 83.60
IUUC-Tme-126891 Tuber melanosporum 35.15 2.00e-18 86.30
IUUC-Tbe-127748 Tupaia belangeri 91.94 9.00e-117 412.00
IUUC-Uma-129463 Ustilago maydis 25.11 1.00e-07 50.40
IUUC-Vda-129820 Verticillium dahliae 32.19 1.00e-11 63.50
IUUC-Vpa-130744 Vicugna pacos 93.81 2.00e-117 414.00
IUUC-Vvi-131735 Vitis vinifera 34.40 4.00e-30 124.00
IUUC-Xtr-132666 Xenopus tropicalis 50.00 2.00e-58 218.00
IUUC-Xma-134199 Xiphophorus maculatus 64.15 3.00e-70 258.00
IUUC-Yli-134333 Yarrowia lipolytica 33.33 1.00e-20 95.10
IUUC-Zma-135340 Zea mays 32.97 4.00e-18 84.70
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved