iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000166348.18	ENST00000418501.5	ENSP00000404644.1
ENSG00000166348.18	ENST00000466048.6	ENSP00000473466.1
ENSG00000166348.18	ENST00000424265.5	ENSP00000399972.1
ENSG00000166348.18	ENST00000339859.8	ENSP00000345216.4
ENSG00000166348.18	ENST00000451492.5	ENSP00000402435.1
ENSG00000166348.18	ENST00000422491.6	ENSP00000407368.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	19302785

Classification

Family	E-value	Score	Start	End
DUB/USP	4.50e-24	86.9	32	349

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNl..gNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavspre.....llkalkkeaeefsg 86
           Gl+N   +N+C++NS+LQ+L+++  +r+ + + +++k+  +       ++ ++l+ +f++++ +++++v p++     l k++++e+ +f+ 
   Q: 32   GLSNEpgQNSCFLNSALQVLWHLDIFRRSFRQLTTHKCMGD------SCIFCALKGIFNQFQ-CSSEKVLPSDtlrsaLAKTFQDEQ-RFQL 115
           88887668******************************986......59************5.555555555543333555555444.599* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
               Da E+++ ll +++ ++                    de +e+  + ++++ ++ F ++l +q++c +c+ +s    pf+++   ++ 
   Q: 116  GIMDDAAECFENLLMRIHFHI-------------------ADETKEDICTAQHCISHQKFAMTLFEQCVCTSCGATSDPL-PFIQMVHYIST 187
           *********************...................3455677899*************************99766.9*********9 PP
   S: 179  keetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
            + +++             +++ +  ++ +  g+ +   ++c ++ +  +++   + P+++++ L +   s + +  e +  ++ +   L+l
   Q: 188  TSLCNQAicmlerrekPSPSMFGELLQNASTMGDLRNCPSNCGERIR-IRRVL-MNAPQIITIGLVWD--SDHSDLAEDVIHSLGTC--LKL 273
           99988889999999985556666666677777666667777777664.56655.566**********9..33334444444444444..555 PP
   S: 262  sp..fctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtev..keeevleetg...staYvlfY 335
               f ++ ++  k+++ Y L+++++++G     HY ++  ++k + W++fdD +V+e+  k+++v++++     ++ +l+Y
   Q: 274  GDlfFRVT-DDRAKQSELY-LVGMICYYG----KHYSTFFFQTKIRkWMYFDDAHVKEIgpKWKDVVTKCIkghYQPLLLLY 349
           55213333.3333335555.*********....9*****99987767************76689998865555555556666 PP

Organism

Homo sapiens

Functional Description
(View)

Weakly expressed in a few tissues.

Protein Sequence
(Fasta)

MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS 60
FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGCGCC AGGAGCTGTG AGTGCGACAC CCTCAGGGGG GCGGGGCCGG GGGTAACGGG 60
GTGCAGGGGG TAGCGCCTGG GGAGGGGGTG CGGGGAAGGT TAGGTCGCGG GAGGAATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom

PROSITE

PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination

KEGG

hsa:159195

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000820	Aegilops tauschii	29.76	2.00e-18	87.00
IUUC-Aml-001414	Ailuropoda melanoleuca	87.18	0.00e+00	2586.00
IUUC-Apl-004044	Anas platyrhynchos	79.68	0.00e+00	1233.00
IUUC-Aca-004351	Anolis carolinensis	58.60	0.00e+00	1551.00
IUUC-Aly-005468	Arabidopsis lyrata	32.78	3.00e-43	171.00
IUUC-Ath-007147	Arabidopsis thaliana	32.65	4.00e-42	167.00
IUUC-Ame-011525	Astyanax mexicanus	61.18	0.00e+00	979.00
IUUC-Bta-013344	Bos taurus	85.12	0.00e+00	2542.00
IUUC-Bdi-015058	Brachypodium distachyon	32.13	5.00e-41	164.00
IUUC-Bol-015670	Brassica oleracea	31.78	1.00e-39	158.00
IUUC-Bra-016731	Brassica rapa	32.36	7.00e-42	167.00
IUUC-Cja-018724	Callithrix jacchus	94.77	0.00e+00	2846.00
IUUC-Cfa-021222	Canis familiaris	86.92	0.00e+00	2644.00
IUUC-Cpo-021795	Cavia porcellus	85.33	0.00e+00	2093.00
IUUC-Csa-023262	Chlorocebus sabaeus	96.56	0.00e+00	2984.00
IUUC-Cho-024422	Choloepus hoffmanni	83.78	0.00e+00	2052.00
IUUC-Cin-025752	Ciona intestinalis	68.60	7.00e-48	182.00
IUUC-Csv-026063	Ciona savignyi	56.10	6.00e-112	397.00
IUUC-Dre-028046	Danio rerio	64.38	0.00e+00	962.00
IUUC-Dno-029417	Dasypus novemcinctus	81.60	0.00e+00	2370.00
IUUC-Dor-030653	Dipodomys ordii	74.30	0.00e+00	1010.00
IUUC-Dme-032071	Drosophila melanogaster	53.82	2.00e-104	374.00
IUUC-Ete-032692	Echinops telfairi	66.09	0.00e+00	756.00
IUUC-Eca-033235	Equus caballus	86.87	0.00e+00	2277.00
IUUC-Eeu-034975	Erinaceus europaeus	65.77	0.00e+00	922.00
IUUC-Fca-036070	Felis catus	86.01	0.00e+00	2632.00
IUUC-Fal-037089	Ficedula albicollis	60.29	0.00e+00	1665.00
IUUC-Gmo-038653	Gadus morhua	74.93	1.00e-173	602.00
IUUC-Gga-041241	Gallus gallus	60.98	0.00e+00	1667.00
IUUC-Gac-042157	Gasterosteus aculeatus	80.20	0.00e+00	682.00
IUUC-Gma-043273	Glycine max	31.20	2.00e-37	152.00
IUUC-Ggo-045626	Gorilla gorilla	99.35	0.00e+00	3051.00
IUUC-Hvu-047657	Hordeum vulgare	31.67	6.00e-42	167.00
IUUC-Itr-048187	Ictidomys tridecemlineatus	76.66	0.00e+00	2357.00
IUUC-Lch-049712	Latimeria chalumnae	87.79	0.00e+00	717.00
IUUC-Lpe-051572	Leersia perrieri	32.05	7.00e-39	157.00
IUUC-Loc-052615	Lepisosteus oculatus	66.45	0.00e+00	1023.00
IUUC-Laf-054578	Loxodonta africana	74.98	0.00e+00	1560.00
IUUC-Mcc-054696	Macaca mulatta	96.80	0.00e+00	2947.00
IUUC-Meu-056841	Macropus eugenii	54.92	0.00e+00	684.00
IUUC-Mga-059519	Meleagris gallopavo	49.06	0.00e+00	1138.00
IUUC-Mmr-060701	Microcebus murinus	88.13	0.00e+00	2570.00
IUUC-Mdo-062433	Monodelphis domestica	69.16	0.00e+00	1969.00
IUUC-Mmu-063480	Mus musculus	71.05	0.00e+00	1468.00
IUUC-Mac-064469	Musa acuminata	31.89	4.00e-19	90.90
IUUC-Mpu-066404	Mustela putorius furo	86.96	0.00e+00	2675.00
IUUC-Mlu-067841	Myotis lucifugus	76.88	0.00e+00	1562.00
IUUC-Nle-070110	Nomascus leucogenys	98.68	0.00e+00	2607.00
IUUC-Opr-070676	Ochotona princeps	85.53	0.00e+00	1365.00
IUUC-Ont-072289	Oreochromis niloticus	71.10	0.00e+00	712.00
IUUC-Oan-073551	Ornithorhynchus anatinus	66.30	0.00e+00	1665.00
IUUC-Ocu-074729	Oryctolagus cuniculus	86.89	0.00e+00	2608.00
IUUC-Obr-076268	Oryza brachyantha	33.24	3.00e-42	167.00
IUUC-Ogl-077138	Oryza glaberrima	32.35	2.00e-39	158.00
IUUC-Oin-079125	Oryza indica	32.35	3.00e-39	157.00
IUUC-Opu-083823	Oryza punctata	32.94	6.00e-40	160.00
IUUC-Ola-086742	Oryzias latipes	80.43	0.00e+00	648.00
IUUC-Oga-088920	Otolemur garnettii	90.14	0.00e+00	2227.00
IUUC-Oar-089644	Ovis aries	85.06	0.00e+00	2533.00
IUUC-Ptr-091530	Pan troglodytes	99.51	0.00e+00	2632.00
IUUC-Pan-092190	Papio anubis	99.00	0.00e+00	1725.00
IUUC-Psi-094022	Pelodiscus sinensis	60.24	0.00e+00	1646.00
IUUC-Pma-094745	Petromyzon marinus	59.89	2.00e-134	472.00
IUUC-Pfo-096072	Poecilia formosa	79.23	0.00e+00	699.00
IUUC-Pab-097979	Pongo abelii	98.82	0.00e+00	2396.00
IUUC-Pop-099539	Populus trichocarpa	31.69	1.00e-37	152.00
IUUC-Pca-101005	Procavia capensis	71.88	0.00e+00	2020.00
IUUC-Ppe-101918	Prunus persica	30.90	9.00e-39	156.00
IUUC-Pva-103125	Pteropus vampyrus	85.35	0.00e+00	2491.00
IUUC-Rno-105463	Rattus norvegicus	76.99	0.00e+00	2280.00
IUUC-Sha-107164	Sarcophilus harrisii	69.28	0.00e+00	1885.00
IUUC-Sit-110021	Setaria italica	32.26	2.00e-37	152.00
IUUC-Sly-110975	Solanum lycopersicum	31.34	4.00e-39	157.00
IUUC-Stu-112904	Solanum tuberosum	31.40	2.00e-37	152.00
IUUC-Sar-113423	Sorex araneus	64.66	0.00e+00	894.00
IUUC-Sbi-114345	Sorghum bicolor	32.84	2.00e-41	165.00
IUUC-Ssc-116206	Sus scrofa	85.17	0.00e+00	2506.00
IUUC-Tgu-116521	Taeniopygia guttata	94.50	0.00e+00	795.00
IUUC-Tru-118155	Takifugu rubripes	70.20	2.00e-172	598.00
IUUC-Tsy-118998	Tarsius syrichta	85.24	0.00e+00	2334.00
IUUC-Tni-120257	Tetraodon nigroviridis	80.36	0.00e+00	664.00
IUUC-Tca-121692	Theobroma cacao	31.87	2.00e-38	155.00
IUUC-Tae-125619	Triticum aestivum	31.94	9.00e-43	169.00
IUUC-Tur-126027	Triticum urartu	31.67	2.00e-42	169.00
IUUC-Tbe-128072	Tupaia belangeri	68.75	4.00e-163	568.00
IUUC-Ttr-128290	Tursiops truncatus	85.49	0.00e+00	1994.00
IUUC-Vpa-130213	Vicugna pacos	84.00	0.00e+00	2137.00
IUUC-Vvi-131652	Vitis vinifera	31.20	1.00e-38	156.00
IUUC-Xtr-131831	Xenopus tropicalis	53.47	0.00e+00	1431.00
IUUC-Xma-133409	Xiphophorus maculatus	60.31	0.00e+00	847.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence