iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18671972

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.18	14.0	503	547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpC....gHvfhadClqkwpglknssskefrCP 43
           C +C+e+++d +++++C    gH f++ C   +  + +   +e +CP
   Q: 503  CTLCRERLED-THFVQCpsvpGHKFCFPCSREF-IKAQGPAGEVYCP 547
           9*********.******************7666.6666778888888 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

Protein Sequence
(Fasta)

MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID AARQLKRSHV 60
LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS GTGGGVSGQD RYDRATSSGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAACTTTCC CTGCGAAGCG GCCTCTGGGG CAGAAGAAGG AGGTGGAGGC GGCGGCGGCC 60
GTTGCAGCGG CGGCGGCGAG AGCGGCGGGA GCCCGAGGCG GCGGCGCTCG CGGCCCATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR022750--Interferon_reg_fac2-bd1_2_Znf
IPR018957--Znf_C3HC4_RING-type
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF11261--IRF-2BP1_2
PF00097--zf-C3HC4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0046872--F:metal ion binding
GO:0016740--F:transferase activity
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:26145

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000186	Aegilops tauschii	35.59	1.00e-02	32.30
IUUC-Aca-004493	Anolis carolinensis	58.87	0.00e+00	630.00
IUUC-Ame-011922	Astyanax mexicanus	48.48	2.00e-151	529.00
IUUC-Bta-012691	Bos taurus	96.38	0.00e+00	856.00
IUUC-Cfa-020153	Canis familiaris	98.80	0.00e+00	953.00
IUUC-Cpo-021918	Cavia porcellus	95.49	0.00e+00	929.00
IUUC-Csa-023365	Chlorocebus sabaeus	99.49	0.00e+00	962.00
IUUC-Dre-027787	Danio rerio	48.82	3.00e-145	509.00
IUUC-Dno-029864	Dasypus novemcinctus	96.58	0.00e+00	996.00
IUUC-Dor-030217	Dipodomys ordii	96.31	0.00e+00	729.00
IUUC-Eca-033451	Equus caballus	98.77	0.00e+00	944.00
IUUC-Fca-035677	Felis catus	98.12	0.00e+00	965.00
IUUC-Gmo-039514	Gadus morhua	42.44	1.00e-81	297.00
IUUC-Ggo-045243	Gorilla gorilla	99.83	0.00e+00	962.00
IUUC-Itr-048330	Ictidomys tridecemlineatus	98.63	0.00e+00	949.00
IUUC-Lch-049976	Latimeria chalumnae	54.37	1.00e-168	586.00
IUUC-Mcc-055423	Macaca mulatta	99.32	0.00e+00	961.00
IUUC-Meu-056349	Macropus eugenii	74.30	3.00e-163	568.00
IUUC-Mmr-061735	Microcebus murinus	99.32	0.00e+00	962.00
IUUC-Mdo-062840	Monodelphis domestica	72.82	5.00e-136	478.00
IUUC-Mmu-063429	Mus musculus	96.40	0.00e+00	912.00
IUUC-Mpu-066580	Mustela putorius furo	98.12	0.00e+00	949.00
IUUC-Nle-069106	Nomascus leucogenys	99.66	0.00e+00	973.00
IUUC-Ont-071903	Oreochromis niloticus	42.29	1.00e-84	307.00
IUUC-Ocu-074681	Oryctolagus cuniculus	77.27	4.00e-180	624.00
IUUC-Obr-076824	Oryza brachyantha	29.63	1.40e-01	30.40
IUUC-Oga-088405	Otolemur garnettii	97.43	0.00e+00	984.00
IUUC-Oar-089381	Ovis aries	94.25	0.00e+00	709.00
IUUC-Ptr-091612	Pan troglodytes	100.00	0.00e+00	964.00
IUUC-Pan-091919	Papio anubis	99.32	0.00e+00	968.00
IUUC-Pfo-096484	Poecilia formosa	47.18	6.00e-119	421.00
IUUC-Pab-098642	Pongo abelii	99.83	0.00e+00	964.00
IUUC-Ppe-101159	Prunus persica	27.52	2.40e-02	33.50
IUUC-Pva-102937	Pteropus vampyrus	98.46	0.00e+00	994.00
IUUC-Rno-105343	Rattus norvegicus	96.58	0.00e+00	901.00
IUUC-Sly-111785	Solanum lycopersicum	31.88	1.60e-02	33.10
IUUC-Ssc-115265	Sus scrofa	98.29	0.00e+00	968.00
IUUC-Tru-117754	Takifugu rubripes	40.67	2.00e-106	380.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence