iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	11352657

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.012	17.8	380	422

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           C iC++  k+ +l+lpC H + ++ C + +   ++    + +CPlCr
   Q: 380  CVICQDQSKT-VLLLPCRHlCLCQACTEIL---MRHPVYHRNCPLCR 422
           ********99.********888****8656...555677788****8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEAVYLVVNG LGLVLDVLTL VLDLNFLLVS SLLASLAWLL AFVYNLPHTV LTSLLHLGRG 60
VLLSLLALIE AVVRFTCGGL QALCTLLYSC CSGLESLKLL GHLASHGALR SREILHRGVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACAAGATG GCGGCGCCCA GCGGAGTAGG GGCTGCGCTT GGGGTTTGCT GAAGCTGGCT 60
GCCTCTCCCA CTCCCCTTTT GGGTGCAAAG CGCCGCTAGC GGGAAGACGG GGGCCGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0008270--F:zinc ion binding

KEGG

hsa:79102

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001389	Ailuropoda melanoleuca	90.03	2.00e-151	528.00
IUUC-Apl-003417	Anas platyrhynchos	52.05	4.00e-36	145.00
IUUC-Ame-011749	Astyanax mexicanus	36.43	1.00e-52	200.00
IUUC-Bta-012907	Bos taurus	90.28	8.00e-155	540.00
IUUC-Cja-019069	Callithrix jacchus	96.93	0.00e+00	631.00
IUUC-Cfa-020660	Canis familiaris	89.26	4.00e-149	521.00
IUUC-Cpo-022415	Cavia porcellus	84.44	2.00e-167	582.00
IUUC-Csa-024024	Chlorocebus sabaeus	95.13	3.00e-176	611.00
IUUC-Dre-028489	Danio rerio	37.56	5.00e-48	185.00
IUUC-Dno-030009	Dasypus novemcinctus	88.75	1.00e-158	552.00
IUUC-Eca-033987	Equus caballus	92.07	3.00e-175	607.00
IUUC-Fca-035899	Felis catus	92.31	3.00e-161	561.00
IUUC-Fal-037549	Ficedula albicollis	48.76	3.00e-70	258.00
IUUC-Gmo-039608	Gadus morhua	35.08	4.00e-41	162.00
IUUC-Ggr-039953	Gaeumannomyces graminis	31.03	1.00e-03	39.30
IUUC-Gga-040652	Gallus gallus	45.78	5.00e-65	241.00
IUUC-Gac-042116	Gasterosteus aculeatus	35.11	2.00e-46	179.00
IUUC-Ggo-044548	Gorilla gorilla	99.49	0.00e+00	661.00
IUUC-Itr-048675	Ictidomys tridecemlineatus	89.26	3.00e-156	544.00
IUUC-Kpa-049207	Komagataella pastoris	34.43	4.00e-05	43.50
IUUC-Lch-050261	Latimeria chalumnae	41.41	1.00e-68	254.00
IUUC-Loc-052605	Lepisosteus oculatus	42.68	8.00e-51	194.00
IUUC-Laf-054227	Loxodonta africana	87.39	2.00e-138	485.00
IUUC-Mcc-054630	Macaca mulatta	97.95	1.00e-179	622.00
IUUC-Mga-059560	Meleagris gallopavo	46.18	3.00e-57	215.00
IUUC-Mmu-064348	Mus musculus	85.20	7.00e-150	523.00
IUUC-Mpu-066116	Mustela putorius furo	90.79	4.00e-149	521.00
IUUC-Mlu-067380	Myotis lucifugus	87.40	2.00e-132	465.00
IUUC-Nle-069323	Nomascus leucogenys	96.77	0.00e+00	631.00
IUUC-Ont-072568	Oreochromis niloticus	33.60	1.00e-39	157.00
IUUC-Ocu-074125	Oryctolagus cuniculus	87.76	2.00e-147	515.00
IUUC-Ola-086917	Oryzias latipes	75.00	1.00e-25	110.00
IUUC-Oga-088223	Otolemur garnettii	91.30	1.00e-172	599.00
IUUC-Oar-089566	Ovis aries	90.54	4.00e-152	531.00
IUUC-Ptr-090887	Pan troglodytes	99.74	0.00e+00	647.00
IUUC-Pan-092081	Papio anubis	97.18	6.00e-178	617.00
IUUC-Psi-092938	Pelodiscus sinensis	51.13	8.00e-82	297.00
IUUC-Pfo-096343	Poecilia formosa	75.00	9.00e-26	111.00
IUUC-Pab-097798	Pongo abelii	98.21	4.00e-180	624.00
IUUC-Pva-103065	Pteropus vampyrus	90.79	3.00e-163	568.00
IUUC-Rno-106114	Rattus norvegicus	84.30	1.00e-155	542.00
IUUC-Ssc-116131	Sus scrofa	91.05	8.00e-159	553.00
IUUC-Tgu-117281	Taeniopygia guttata	82.35	3.00e-30	122.00
IUUC-Tni-120228	Tetraodon nigroviridis	64.63	3.00e-29	122.00
IUUC-Tme-127098	Tuber melanosporum	33.93	3.00e-05	43.90
IUUC-Tbe-127230	Tupaia belangeri	91.45	8.00e-169	586.00
IUUC-Ttr-128338	Tursiops truncatus	90.79	2.00e-150	525.00
IUUC-Uma-129528	Ustilago maydis	35.00	5.00e-04	40.00
IUUC-Vda-129694	Verticillium dahliae	30.91	3.00e-03	38.10
IUUC-Xma-133728	Xiphophorus maculatus	35.09	2.00e-42	166.00
IUUC-Yli-134469	Yarrowia lipolytica	31.88	8.00e-06	45.80

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence