iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	67.22	5.00e-155	546.00	IUUC-Hsa-046912

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.

Protein Sequence
(Fasta)

MFEALKEVLG EINSKLAAVN NELSSKIMSE NIVSTRPVAQ AQYCGPYKLE KTLGKGQTGL 60
VKTGTHCITG RKVAIKIVNK EKLSESVLQK VEREIAIMKL IEHPHVLHLY DVYENKKYLY 120

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Nucleotide Sequence
(Fasta)

TGCTCAGGAG CAGAATCAAA AAAAATCCCC GTTTGGAATC CAAGGAAGCT TAAAACTTAG 60
CCGCATGACT GCGCTCGTCA ATCGGGCAAA GTCTGCACAT GTTTGAAGCT CTCAAGGTGA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0770--Synapse
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0030424--C:axon
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005634--C:nucleus
GO:0045202--C:synapse
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0008088--P:axo-dendritic transport
GO:0007411--P:axon guidance
GO:0034613--P:cellular protein localization
GO:0007163--P:establishment or maintenance of cell polarity
GO:0035556--P:intracellular signal transduction
GO:0018105--P:peptidyl-serine phosphorylation
GO:0030516--P:regulation of axon extension
GO:0007416--P:synapse assembly
GO:0050808--P:synapse organization
GO:0048489--P:synaptic vesicle transport

KEGG

cel:CELE_F15A2.6

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003374	Anas platyrhynchos	65.37	1.00e-136	479.00
IUUC-Bta-012608	Bos taurus	66.93	2.00e-149	521.00
IUUC-Cja-019882	Callithrix jacchus	67.71	3.00e-151	527.00
IUUC-Cpo-021604	Cavia porcellus	66.50	2.00e-151	528.00
IUUC-Csv-025996	Ciona savignyi	67.41	1.00e-149	521.00
IUUC-Dre-028706	Danio rerio	66.57	2.00e-136	478.00
IUUC-Dme-031685	Drosophila melanogaster	75.13	2.00e-175	608.00
IUUC-Eca-033483	Equus caballus	66.01	4.00e-134	470.00
IUUC-Fal-037499	Ficedula albicollis	66.57	6.00e-137	479.00
IUUC-Gmo-039305	Gadus morhua	67.09	3.00e-152	531.00
IUUC-Gac-042120	Gasterosteus aculeatus	67.53	9.00e-144	502.00
IUUC-Hsa-046912	Homo sapiens	68.49	1.00e-161	562.00
IUUC-Itr-048825	Ictidomys tridecemlineatus	67.27	1.00e-150	525.00
IUUC-Mcc-055306	Macaca mulatta	67.53	3.00e-151	527.00
IUUC-Mga-059357	Meleagris gallopavo	66.29	1.00e-135	475.00
IUUC-Mmr-061711	Microcebus murinus	60.11	1.00e-113	402.00
IUUC-Mmu-063511	Mus musculus	68.49	3.00e-161	560.00
IUUC-Ont-072425	Oreochromis niloticus	67.74	3.00e-154	537.00
IUUC-Ola-086969	Oryzias latipes	71.63	7.00e-150	523.00
IUUC-Pan-092910	Papio anubis	68.49	9.00e-162	562.00
IUUC-Psi-093857	Pelodiscus sinensis	70.42	1.00e-89	322.00
IUUC-Pfo-097195	Poecilia formosa	68.24	1.00e-155	541.00
IUUC-Rno-105039	Rattus norvegicus	71.95	6.00e-151	526.00
IUUC-Sha-107449	Sarcophilus harrisii	64.18	5.00e-125	440.00
IUUC-Tgu-117372	Taeniopygia guttata	66.29	2.00e-135	474.00
IUUC-Tru-118645	Takifugu rubripes	67.45	1.00e-144	505.00
IUUC-Tni-120483	Tetraodon nigroviridis	70.49	1.00e-152	532.00
IUUC-Tme-126887	Tuber melanosporum	48.77	1.00e-88	318.00
IUUC-Xtr-132457	Xenopus tropicalis	71.35	5.00e-150	523.00
IUUC-Xma-134021	Xiphophorus maculatus	67.70	3.00e-146	510.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence