iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046126

UUCD1 version

UUC-HoS-01075

Ensembl Protein ID

ENSP00000323687.6

UniProt Accession

Q9C0C9; A6NDU5; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9H6E6; Q9H7E4; Q9H9B2; UBE2O_HUMAN

Genbank Protein ID

BAB21825.1; EAW89396.1; AAH04525.2; AAH22237.1; AAH25977.1; AAH36820.1; AAH51868.2; CAH10644.1; BAB14320.1; BAB14948.1; BAB15313.1

Protein Name

(E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-protein ligase O

Genbank Nucleotide ID

AB051521; AC090699; BC004525; BC022237; BC025977; BC036820; BC051868; AL832432; AK022940; AK024657; AK025999

Gene Name

UBE2O; KIAA1734

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000175931.12	ENST00000319380.11	ENSP00000323687.6
ENSG00000175931.12	ENST00000587127.1	ENSP00000468498.1
ENSG00000175931.12	ENST00000590658.1	ENSP00000467623.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	11806825

Classification

Family	E-value	Score	Start	End
E2/UBC	1.00e-29	104.7	958	1102

Active Site

Position(s)	Description	Evidence
1040	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk...ifhPnvyenGkvClsilk. 87
           ++ke++ l+++ pegi++k+ ++  ++ +++li Gp++tpYe+g++ ++i++p+ YP+ PP++++l++   +++Pn+y+nGkvC+s+l+ 
   Q: 958  VRKEMALLATSLPEGIMVKTFED-RMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQcsgRLNPNLYDNGKVCVSLLGt 1046
           589********************.5*******************************************999*****************66 PP
   S: 88   ....eeekWspalsvesvllsiqsll..aepnpesplneeaa...ellkknreeykk 135
                +e+W++++s+ +vl+siq l+  +ep+++++  ++ +   e ++++r+ y++
   Q: 1047 wigkGTERWTSKSSLLQVLISIQGLIlvNEPYYNEAGFDSDRglqEGYENSRC-YNE 1102
           666699******************9999*******998887655456666665.666 PP

Organism

Homo sapiens

Functional Description
(View)

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Protein Sequence
(Fasta)

MADPAAPTPA APAPAQAPAP APEAVPAPAA APVPAPAPAS DSASGPSSDS GPEAGSQRLL 60
FSHDLVSGRY RGSVHFGLVR LIHGEDSDSE GEEEGRGSSG CSEAGGAGHE EGRASPLRRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCTCCCCG CGCCTCGTTC GCCGCCGCTG TCGCCGCCGC CGCCCGAGAC TCGCGCAGAG 60
CAGTTATGGC GGATCCCGCA GCCCCCACGC CCGCAGCTCC CGCTCCAGCC CAGGCCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042147--P:retrograde transport, endosome to Golgi

KEGG

hsa:63893

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000412	Aegilops tauschii	44.44	1.00e-45	178.00
IUUC-Aml-001463	Ailuropoda melanoleuca	95.76	0.00e+00	1980.00
IUUC-Atr-002469	Amborella trichopoda	43.94	2.00e-41	164.00
IUUC-Apl-004084	Anas platyrhynchos	78.74	0.00e+00	1610.00
IUUC-Aca-004435	Anolis carolinensis	72.44	0.00e+00	1600.00
IUUC-Aly-005970	Arabidopsis lyrata	43.78	1.00e-45	178.00
IUUC-Ath-007320	Arabidopsis thaliana	43.78	1.00e-45	179.00
IUUC-Acl-008031	Aspergillus clavatus	44.23	7.00e-33	136.00
IUUC-Afl-008480	Aspergillus flavus	37.31	2.00e-35	145.00
IUUC-Afu-009040	Aspergillus fumigatus	40.31	1.00e-33	139.00
IUUC-Ani-009341	Aspergillus nidulans	41.77	2.00e-23	105.00
IUUC-Ang-009816	Aspergillus niger	39.51	3.00e-32	134.00
IUUC-Aor-010121	Aspergillus oryzae	38.25	2.00e-30	128.00
IUUC-Ate-010487	Aspergillus terreus	36.06	9.00e-35	142.00
IUUC-Ame-010604	Astyanax mexicanus	63.04	0.00e+00	1306.00
IUUC-Bta-013234	Bos taurus	95.47	0.00e+00	2049.00
IUUC-Bdi-015067	Brachypodium distachyon	38.39	2.00e-41	165.00
IUUC-Bol-016468	Brassica oleracea	44.70	1.00e-45	179.00
IUUC-Bra-016796	Brassica rapa	44.70	6.00e-46	180.00
IUUC-Cja-018812	Callithrix jacchus	98.46	0.00e+00	2063.00
IUUC-Cfa-020448	Canis familiaris	95.61	0.00e+00	1937.00
IUUC-Cpo-021316	Cavia porcellus	96.05	0.00e+00	2056.00
IUUC-Csa-023869	Chlorocebus sabaeus	99.19	0.00e+00	2065.00
IUUC-Cin-025614	Ciona intestinalis	36.81	2.00e-44	172.00
IUUC-Cne-026812	Cryptococcus neoformans	44.26	1.00e-45	178.00
IUUC-Dre-028814	Danio rerio	65.94	0.00e+00	873.00
IUUC-Dno-029590	Dasypus novemcinctus	95.54	0.00e+00	1442.00
IUUC-Dor-030644	Dipodomys ordii	97.13	0.00e+00	658.00
IUUC-Dse-031508	Dothistroma septosporum	36.89	3.00e-34	140.00
IUUC-Dme-032211	Drosophila melanogaster	49.32	6.00e-65	243.00
IUUC-Eca-033413	Equus caballus	92.07	0.00e+00	1843.00
IUUC-Eeu-035035	Erinaceus europaeus	92.21	0.00e+00	1416.00
IUUC-Fca-035610	Felis catus	96.09	0.00e+00	2040.00
IUUC-Fal-036879	Ficedula albicollis	76.49	0.00e+00	1559.00
IUUC-Gmo-039262	Gadus morhua	65.40	0.00e+00	955.00
IUUC-Gga-040958	Gallus gallus	76.25	0.00e+00	1678.00
IUUC-Gac-041730	Gasterosteus aculeatus	62.95	0.00e+00	1369.00
IUUC-Gma-042690	Glycine max	44.70	8.00e-44	172.00
IUUC-Ggo-045316	Gorilla gorilla	99.84	0.00e+00	2068.00
IUUC-Hvu-047713	Hordeum vulgare	40.00	3.00e-42	167.00
IUUC-Itr-048048	Ictidomys tridecemlineatus	95.16	0.00e+00	1980.00
IUUC-Lch-050531	Latimeria chalumnae	63.21	0.00e+00	1399.00
IUUC-Lpe-051268	Leersia perrieri	47.17	2.00e-39	157.00
IUUC-Loc-052209	Lepisosteus oculatus	66.30	0.00e+00	1427.00
IUUC-Lma-053064	Leptosphaeria maculans	42.99	3.00e-35	144.00
IUUC-Laf-053567	Loxodonta africana	90.88	2.00e-124	438.00
IUUC-Mcc-055722	Macaca mulatta	99.27	0.00e+00	2066.00
IUUC-Meu-056834	Macropus eugenii	89.61	2.00e-179	623.00
IUUC-Mtr-057804	Medicago truncatula	30.03	6.00e-60	226.00
IUUC-Mga-059571	Meleagris gallopavo	78.92	0.00e+00	1586.00
IUUC-Mvi-060389	Microbotryum violaceum	43.33	4.00e-44	173.00
IUUC-Mmr-061535	Microcebus murinus	97.41	0.00e+00	1974.00
IUUC-Mdo-062111	Monodelphis domestica	86.84	0.00e+00	1838.00
IUUC-Mmu-064171	Mus musculus	94.52	0.00e+00	2048.00
IUUC-Mac-065585	Musa acuminata	39.45	2.00e-41	164.00
IUUC-Mpu-065697	Mustela putorius furo	95.78	0.00e+00	1890.00
IUUC-Mlu-068177	Myotis lucifugus	92.39	0.00e+00	1863.00
IUUC-Nfi-068366	Neosartorya fischeri	38.68	8.00e-34	139.00
IUUC-Nle-069704	Nomascus leucogenys	98.10	0.00e+00	1974.00
IUUC-Opr-070982	Ochotona princeps	94.09	0.00e+00	1955.00
IUUC-Ont-072115	Oreochromis niloticus	60.04	0.00e+00	1311.00
IUUC-Oan-072991	Ornithorhynchus anatinus	84.90	0.00e+00	787.00
IUUC-Ocu-073994	Oryctolagus cuniculus	94.44	0.00e+00	1919.00
IUUC-Oba-075236	Oryza barthii	37.27	7.00e-42	166.00
IUUC-Obr-076363	Oryza brachyantha	28.29	3.00e-54	207.00
IUUC-Ogl-077340	Oryza glaberrima	37.27	1.00e-41	166.00
IUUC-Ogu-078661	Oryza glumaepatula	43.44	2.00e-42	168.00
IUUC-Oin-080044	Oryza indica	46.70	1.00e-44	174.00
IUUC-Olo-080524	Oryza longistaminata	46.70	6.00e-45	174.00
IUUC-Ome-081767	Oryza meridionalis	37.27	5.00e-42	166.00
IUUC-Oni-082897	Oryza nivara	37.27	8.00e-42	166.00
IUUC-Opu-083143	Oryza punctata	28.07	4.00e-53	203.00
IUUC-Oru-084813	Oryza rufipogon	37.27	9.00e-42	166.00
IUUC-Osa-085536	Oryza sativa	37.27	9.00e-42	166.00
IUUC-Ola-087200	Oryzias latipes	64.71	0.00e+00	1271.00
IUUC-Oga-088737	Otolemur garnettii	96.95	0.00e+00	2003.00
IUUC-Oar-090259	Ovis aries	89.42	0.00e+00	1821.00
IUUC-Ptr-091146	Pan troglodytes	99.81	0.00e+00	1779.00
IUUC-Pan-091743	Papio anubis	99.27	0.00e+00	2066.00
IUUC-Psi-093231	Pelodiscus sinensis	78.74	0.00e+00	1627.00
IUUC-Pma-094499	Petromyzon marinus	56.76	2.00e-153	537.00
IUUC-Pno-095065	Phaeosphaeria nodorum	45.71	5.00e-31	130.00
IUUC-Ppa-095324	Physcomitrella patens	46.48	2.00e-53	204.00
IUUC-Pfo-096799	Poecilia formosa	63.87	0.00e+00	910.00
IUUC-Pab-098220	Pongo abelii	99.27	0.00e+00	2056.00
IUUC-Pop-099156	Populus trichocarpa	43.06	3.00e-42	167.00
IUUC-Pca-100963	Procavia capensis	89.01	0.00e+00	1814.00
IUUC-Ppe-101372	Prunus persica	41.70	1.00e-43	172.00
IUUC-Pva-102384	Pteropus vampyrus	94.99	0.00e+00	1976.00
IUUC-Pte-104381	Pyrenophora teres	42.93	8.00e-37	149.00
IUUC-Pyt-104607	Pyrenophora triticirepentis	39.19	8.00e-37	149.00
IUUC-Rno-105947	Rattus norvegicus	94.47	0.00e+00	1937.00
IUUC-Sha-106642	Sarcophilus harrisii	87.18	0.00e+00	1751.00
IUUC-Smo-108758	Selaginella moellendorffii	38.85	6.00e-53	202.00
IUUC-Sit-110041	Setaria italica	39.73	6.00e-43	169.00
IUUC-Sly-111922	Solanum lycopersicum	44.13	1.00e-43	171.00
IUUC-Stu-112339	Solanum tuberosum	39.91	7.00e-44	172.00
IUUC-Sbi-114493	Sorghum bicolor	27.79	4.00e-61	230.00
IUUC-Sre-114954	Sporisorium reilianum	44.81	3.00e-46	180.00
IUUC-Ssc-115901	Sus scrofa	87.93	0.00e+00	1917.00
IUUC-Tgu-116873	Taeniopygia guttata	79.40	0.00e+00	1585.00
IUUC-Tru-118710	Takifugu rubripes	56.34	0.00e+00	782.00
IUUC-Tsy-119256	Tarsius syrichta	85.44	0.00e+00	670.00
IUUC-Tni-120839	Tetraodon nigroviridis	62.77	0.00e+00	852.00
IUUC-Tca-121665	Theobroma cacao	29.35	3.00e-59	224.00
IUUC-Tae-125159	Triticum aestivum	40.96	8.00e-52	199.00
IUUC-Tme-127207	Tuber melanosporum	42.33	2.00e-34	141.00
IUUC-Ttr-128990	Tursiops truncatus	95.80	0.00e+00	2046.00
IUUC-Uma-129323	Ustilago maydis	43.04	1.00e-46	182.00
IUUC-Vvi-131411	Vitis vinifera	42.40	1.00e-43	172.00
IUUC-Xtr-132000	Xenopus tropicalis	64.24	0.00e+00	650.00
IUUC-Xma-133380	Xiphophorus maculatus	65.69	0.00e+00	1266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence