iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	4.30e-18	67.1	34	98
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.10e-08	33.4	133	157

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv ++ g +e+++h+ vLa+sS++F+a+f + ++e+  + +v++k+++p  + ++++++Ytg++ 
   Q: 34   TDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKS-EAKVQLKGIDPPTLDQIVSYVYTGEAH 98
           7***********************************96.************************985 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaald 25
           ++Nclg++r++++++c+ Lk++a++
   Q: 133  PSNCLGMIRLSEILSCETLKKKARE 157
           89*********************86 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDEESLDGLL FKDHDFSSDL LRQLNSLRQS RILTDVSICA GAREIPCHRN VLASSSPYFR 60
AMFCSSFREK SEAKVQLKGI DPPTLDQIVS YVYTGEAHIA TDNVLPVMEA ASMLQFPKLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCTTCCT TCCCTCTTTG TAGGATGGAC GAGGAGTCAC TAGATGGGCT GCTCTTCAAA 60
GACCACGACT TCTCTTCTGA CTTGTTGAGG CAGCTCAACA GCTTAAGGCA AAGCAGGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:340359

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001590	Ailuropoda melanoleuca	86.25	0.00e+00	1064.00
IUUC-Apl-003717	Anas platyrhynchos	71.65	0.00e+00	855.00
IUUC-Aca-005179	Anolis carolinensis	68.70	0.00e+00	867.00
IUUC-Ame-010815	Astyanax mexicanus	55.61	0.00e+00	669.00
IUUC-Bta-013356	Bos taurus	86.08	0.00e+00	1025.00
IUUC-Cja-019411	Callithrix jacchus	96.04	0.00e+00	1168.00
IUUC-Cfa-020730	Canis familiaris	86.60	0.00e+00	1068.00
IUUC-Cpo-022406	Cavia porcellus	84.08	0.00e+00	1007.00
IUUC-Csa-023904	Chlorocebus sabaeus	97.76	0.00e+00	1156.00
IUUC-Dre-028345	Danio rerio	56.09	0.00e+00	682.00
IUUC-Dno-029809	Dasypus novemcinctus	86.40	0.00e+00	1053.00
IUUC-Dor-030675	Dipodomys ordii	80.07	1.00e-139	490.00
IUUC-Ete-032256	Echinops telfairi	80.00	0.00e+00	761.00
IUUC-Eeu-034796	Erinaceus europaeus	84.08	0.00e+00	1014.00
IUUC-Fca-036124	Felis catus	87.72	0.00e+00	1058.00
IUUC-Fal-036887	Ficedula albicollis	70.96	0.00e+00	856.00
IUUC-Gmo-039299	Gadus morhua	55.23	0.00e+00	643.00
IUUC-Gga-040534	Gallus gallus	71.48	0.00e+00	836.00
IUUC-Gac-041280	Gasterosteus aculeatus	55.02	0.00e+00	681.00
IUUC-Ggo-045490	Gorilla gorilla	98.97	0.00e+00	1166.00
IUUC-Itr-048640	Ictidomys tridecemlineatus	88.41	0.00e+00	1057.00
IUUC-Lch-050292	Latimeria chalumnae	64.57	0.00e+00	807.00
IUUC-Loc-051771	Lepisosteus oculatus	57.09	0.00e+00	689.00
IUUC-Laf-053679	Loxodonta africana	86.75	0.00e+00	1034.00
IUUC-Mcc-055329	Macaca mulatta	97.76	0.00e+00	1156.00
IUUC-Meu-056835	Macropus eugenii	71.96	3.00e-126	445.00
IUUC-Mga-059373	Meleagris gallopavo	72.30	0.00e+00	809.00
IUUC-Mmr-061575	Microcebus murinus	91.57	0.00e+00	1113.00
IUUC-Mdo-062142	Monodelphis domestica	77.57	0.00e+00	919.00
IUUC-Mmu-063499	Mus musculus	84.31	0.00e+00	1051.00
IUUC-Mpu-066730	Mustela putorius furo	88.49	0.00e+00	1061.00
IUUC-Mlu-067782	Myotis lucifugus	87.39	0.00e+00	1068.00
IUUC-Nle-069814	Nomascus leucogenys	97.07	0.00e+00	1144.00
IUUC-Opr-070240	Ochotona princeps	83.78	0.00e+00	765.00
IUUC-Ont-071799	Oreochromis niloticus	55.77	0.00e+00	676.00
IUUC-Oan-072938	Ornithorhynchus anatinus	71.33	0.00e+00	846.00
IUUC-Ocu-074650	Oryctolagus cuniculus	88.06	0.00e+00	1083.00
IUUC-Ola-086611	Oryzias latipes	56.16	0.00e+00	654.00
IUUC-Oga-088645	Otolemur garnettii	89.50	0.00e+00	1100.00
IUUC-Oar-090062	Ovis aries	87.11	0.00e+00	1034.00
IUUC-Ptr-091181	Pan troglodytes	91.91	0.00e+00	1094.00
IUUC-Pan-092350	Papio anubis	97.93	0.00e+00	1159.00
IUUC-Psi-093340	Pelodiscus sinensis	72.70	0.00e+00	874.00
IUUC-Pma-094164	Petromyzon marinus	40.17	2.00e-107	383.00
IUUC-Pfo-096935	Poecilia formosa	54.23	0.00e+00	665.00
IUUC-Pab-098553	Pongo abelii	96.90	0.00e+00	1185.00
IUUC-Pca-100886	Procavia capensis	87.26	0.00e+00	1050.00
IUUC-Pva-102455	Pteropus vampyrus	85.40	0.00e+00	1026.00
IUUC-Pyt-104515	Pyrenophora triticirepentis	25.00	3.00e-07	48.90
IUUC-Rno-105744	Rattus norvegicus	84.14	0.00e+00	1047.00
IUUC-Sha-106885	Sarcophilus harrisii	77.15	0.00e+00	942.00
IUUC-Tgu-116582	Taeniopygia guttata	71.13	0.00e+00	862.00
IUUC-Tru-117998	Takifugu rubripes	55.33	0.00e+00	682.00
IUUC-Tni-120407	Tetraodon nigroviridis	56.55	0.00e+00	649.00
IUUC-Tre-122227	Trichoderma reesei	32.94	9.00e-08	50.10
IUUC-Tvi-122551	Trichoderma virens	26.38	6.00e-07	47.00
IUUC-Tbe-127407	Tupaia belangeri	80.77	0.00e+00	855.00
IUUC-Xtr-132841	Xenopus tropicalis	67.30	0.00e+00	812.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence