iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.50e-12	46.8	24	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik..dvqpevfrallkFlYtgkl 65
           +D+++ +g+++f+ahk+vLa+ S +F+ lf ++ +e     +v +k  d+qp+ f+ ll+ +Ytgk+
   Q: 24   CDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSE-----CVRLKptDIQPDIFSYLLHLMYTGKM 85
           8*****************************998777.....58888879****************96 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK MLFVHQTSEC 60
VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK FLHAYPLIQE ASLASQGAFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGACCGCG GCGGCAGCAG CAGCAGCAGC AGCGAGAGGC AGAGGCGGCG GCGGCGGGGA 60
GGACAGCACG GCCGAGGCTG CCCAGAGGCG CCTCCTCCAC ACCCCCCGCC GCAGCAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:57621

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001278	Ailuropoda melanoleuca	98.25	0.00e+00	1007.00
IUUC-Apl-004154	Anas platyrhynchos	88.72	0.00e+00	925.00
IUUC-Aca-004809	Anolis carolinensis	85.41	0.00e+00	844.00
IUUC-Ame-011189	Astyanax mexicanus	51.99	2.00e-145	509.00
IUUC-Bta-012488	Bos taurus	96.50	0.00e+00	979.00
IUUC-Cja-019536	Callithrix jacchus	99.61	0.00e+00	1022.00
IUUC-Cfa-020338	Canis familiaris	97.28	0.00e+00	997.00
IUUC-Cpo-021435	Cavia porcellus	95.72	0.00e+00	985.00
IUUC-Csa-023553	Chlorocebus sabaeus	99.22	0.00e+00	1016.00
IUUC-Cho-024746	Choloepus hoffmanni	95.42	0.00e+00	746.00
IUUC-Dre-028333	Danio rerio	53.02	2.00e-143	502.00
IUUC-Dno-029275	Dasypus novemcinctus	87.96	0.00e+00	880.00
IUUC-Dor-030356	Dipodomys ordii	93.19	0.00e+00	946.00
IUUC-Ete-032667	Echinops telfairi	92.05	0.00e+00	942.00
IUUC-Eca-033847	Equus caballus	97.47	0.00e+00	1000.00
IUUC-Eeu-035174	Erinaceus europaeus	80.86	7.00e-128	451.00
IUUC-Fca-035756	Felis catus	98.05	0.00e+00	1004.00
IUUC-Fal-037515	Ficedula albicollis	89.49	0.00e+00	926.00
IUUC-Gmo-039295	Gadus morhua	54.47	1.00e-145	509.00
IUUC-Gga-040413	Gallus gallus	89.11	0.00e+00	947.00
IUUC-Gac-041532	Gasterosteus aculeatus	55.27	2.00e-147	515.00
IUUC-Ggo-045148	Gorilla gorilla	99.81	0.00e+00	1023.00
IUUC-Itr-047943	Ictidomys tridecemlineatus	98.83	0.00e+00	1016.00
IUUC-Lch-049716	Latimeria chalumnae	71.71	0.00e+00	720.00
IUUC-Loc-052014	Lepisosteus oculatus	58.05	1.00e-168	586.00
IUUC-Laf-053602	Loxodonta africana	96.89	0.00e+00	1008.00
IUUC-Mcc-054967	Macaca mulatta	99.22	0.00e+00	1016.00
IUUC-Meu-056266	Macropus eugenii	90.47	0.00e+00	917.00
IUUC-Mga-059727	Meleagris gallopavo	88.72	0.00e+00	943.00
IUUC-Mdo-062662	Monodelphis domestica	95.33	0.00e+00	979.00
IUUC-Mmu-063728	Mus musculus	94.94	0.00e+00	978.00
IUUC-Mpu-066487	Mustela putorius furo	95.72	0.00e+00	979.00
IUUC-Mlu-067984	Myotis lucifugus	95.53	0.00e+00	996.00
IUUC-Nle-069536	Nomascus leucogenys	99.42	0.00e+00	1017.00
IUUC-Opr-071003	Ochotona princeps	95.14	0.00e+00	977.00
IUUC-Ont-072185	Oreochromis niloticus	57.20	3.00e-151	528.00
IUUC-Oan-073716	Ornithorhynchus anatinus	92.41	0.00e+00	942.00
IUUC-Ocu-073811	Oryctolagus cuniculus	98.64	0.00e+00	1013.00
IUUC-Ola-086731	Oryzias latipes	54.30	2.00e-147	515.00
IUUC-Oga-088649	Otolemur garnettii	97.86	0.00e+00	1007.00
IUUC-Oar-089982	Ovis aries	96.30	0.00e+00	977.00
IUUC-Ptr-090804	Pan troglodytes	99.61	0.00e+00	1023.00
IUUC-Psi-093460	Pelodiscus sinensis	87.16	0.00e+00	896.00
IUUC-Pma-094392	Petromyzon marinus	81.56	2.00e-68	253.00
IUUC-Pfo-096124	Poecilia formosa	55.24	6.00e-150	524.00
IUUC-Pab-097942	Pongo abelii	100.00	0.00e+00	1025.00
IUUC-Pca-100928	Procavia capensis	95.53	0.00e+00	995.00
IUUC-Rno-105175	Rattus norvegicus	94.75	0.00e+00	977.00
IUUC-Sha-106775	Sarcophilus harrisii	94.75	0.00e+00	975.00
IUUC-Ssc-115366	Sus scrofa	96.11	0.00e+00	995.00
IUUC-Tgu-116558	Taeniopygia guttata	89.49	0.00e+00	927.00
IUUC-Tru-117657	Takifugu rubripes	53.63	6.00e-143	500.00
IUUC-Tni-119687	Tetraodon nigroviridis	58.00	2.00e-155	541.00
IUUC-Ttr-128395	Tursiops truncatus	93.97	0.00e+00	967.00
IUUC-Xtr-132095	Xenopus tropicalis	78.60	0.00e+00	838.00
IUUC-Xma-134276	Xiphophorus maculatus	55.65	6.00e-149	520.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence