iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18986647; 14765125; 20628057

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.40e-06	28.6	12	69
E3 activity/RING/RING	6.70e-06	27.6	18	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
           v e+++CpI   + ++Pv +p + + +  ++I +w++++++ cPv+r+ +t   l P  
   Q: 12   VDEDLICPICSGVLEEPVQAPhCEHAFCNACITQWFSQQQT-CPVDRSVVTVAHLRPVP 69
           56899******************************998887.******99998887764 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   +++ p+  p C H+f+  C+ +w       s++++CP++r
   Q: 18   CPICSGVLEE-PVQAPhCEHAFCNACITQW------FSQQQTCPVDR 57
           ****999999.777777*************......********987 PP

Organism

Mus musculus

Functional Description
(View)

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Protein Sequence
(Fasta)

MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 60
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCTTCCGC CCCGTTGCGT AGCAGCAGTG GGCGTGGCTA AGGGCTAACC CGAGACAGCG 60
AGGAGTGGTC GGAACCTTCT TCCCCATCCT TACCTTCCCC TTCCCCTACG GGGAAAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR013010--Znf_SIAH

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF08941--USP8_interact

SMART

SM00184--RING

Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0005128--F:erythropoietin receptor binding
GO:0005135--F:interleukin-3 receptor binding
GO:0031386--F:protein tag
GO:0017160--F:Ral GTPase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:1901525--P:negative regulation of macromitophagy
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010498--P:proteasomal protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:2000114--P:regulation of establishment of cell polarity
GO:0010468--P:regulation of gene expression
GO:0045619--P:regulation of lymphocyte differentiation
GO:0043408--P:regulation of MAPK cascade
GO:0045637--P:regulation of myeloid cell differentiation
GO:0051896--P:regulation of protein kinase B signaling
GO:2000377--P:regulation of reactive oxygen species metabolic process

KEGG

mmu:67588

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002398	Ailuropoda melanoleuca	99.37	0.00e+00	658.00
IUUC-Apl-003568	Anas platyrhynchos	95.91	0.00e+00	631.00
IUUC-Aca-005119	Anolis carolinensis	96.53	0.00e+00	644.00
IUUC-Ame-010708	Astyanax mexicanus	90.85	8.00e-179	619.00
IUUC-Bta-013428	Bos taurus	94.01	4.00e-179	620.00
IUUC-Cja-019844	Callithrix jacchus	99.37	0.00e+00	655.00
IUUC-Cfa-021124	Canis familiaris	99.68	0.00e+00	659.00
IUUC-Cpo-022325	Cavia porcellus	99.37	0.00e+00	658.00
IUUC-Csa-023113	Chlorocebus sabaeus	99.68	0.00e+00	659.00
IUUC-Cho-024991	Choloepus hoffmanni	98.97	5.00e-114	402.00
IUUC-Cne-026870	Cryptococcus neoformans	38.52	4.00e-20	93.20
IUUC-Dre-028730	Danio rerio	90.54	2.00e-178	617.00
IUUC-Dno-028908	Dasypus novemcinctus	99.30	1.00e-171	594.00
IUUC-Dor-030411	Dipodomys ordii	99.37	0.00e+00	659.00
IUUC-Dme-031868	Drosophila melanogaster	57.46	5.00e-111	393.00
IUUC-Ete-032896	Echinops telfairi	81.51	4.00e-125	440.00
IUUC-Eca-034135	Equus caballus	99.68	0.00e+00	659.00
IUUC-Eeu-034675	Erinaceus europaeus	99.37	0.00e+00	657.00
IUUC-Fca-035612	Felis catus	99.68	0.00e+00	659.00
IUUC-Fal-036922	Ficedula albicollis	97.53	3.00e-42	162.00
IUUC-Gmo-039648	Gadus morhua	87.38	7.00e-172	595.00
IUUC-Gga-040474	Gallus gallus	96.85	0.00e+00	645.00
IUUC-Gac-041951	Gasterosteus aculeatus	88.64	9.00e-175	605.00
IUUC-Ggo-045126	Gorilla gorilla	99.37	0.00e+00	655.00
IUUC-Hsa-046402	Homo sapiens	99.68	0.00e+00	659.00
IUUC-Itr-047895	Ictidomys tridecemlineatus	99.68	0.00e+00	659.00
IUUC-Lch-050266	Latimeria chalumnae	93.38	0.00e+00	629.00
IUUC-Loc-052547	Lepisosteus oculatus	91.80	1.00e-179	622.00
IUUC-Laf-054332	Loxodonta africana	99.06	0.00e+00	654.00
IUUC-Mcc-055869	Macaca mulatta	99.68	0.00e+00	659.00
IUUC-Meu-056735	Macropus eugenii	99.65	5.00e-172	596.00
IUUC-Mla-059147	Melampsora laricipopulina	37.11	4.00e-13	68.90
IUUC-Mga-060100	Meleagris gallopavo	96.85	0.00e+00	645.00
IUUC-Mmr-061382	Microcebus murinus	99.68	0.00e+00	659.00
IUUC-Mpu-066709	Mustela putorius furo	99.68	0.00e+00	659.00
IUUC-Mlu-067168	Myotis lucifugus	98.74	0.00e+00	657.00
IUUC-Nle-070176	Nomascus leucogenys	99.68	0.00e+00	659.00
IUUC-Opr-070259	Ochotona princeps	99.37	0.00e+00	658.00
IUUC-Ont-071235	Oreochromis niloticus	89.91	4.00e-177	613.00
IUUC-Oan-072850	Ornithorhynchus anatinus	58.12	6.00e-91	327.00
IUUC-Ocu-074165	Oryctolagus cuniculus	99.37	0.00e+00	658.00
IUUC-Ola-086658	Oryzias latipes	88.33	3.00e-173	600.00
IUUC-Oga-088933	Otolemur garnettii	99.68	0.00e+00	659.00
IUUC-Oar-090089	Ovis aries	99.37	0.00e+00	659.00
IUUC-Ptr-091263	Pan troglodytes	99.68	0.00e+00	659.00
IUUC-Pan-092926	Papio anubis	99.68	0.00e+00	659.00
IUUC-Psi-093934	Pelodiscus sinensis	89.31	4.00e-168	583.00
IUUC-Pma-094578	Petromyzon marinus	68.97	4.00e-127	447.00
IUUC-Pno-094854	Phaeosphaeria nodorum	36.59	2.00e-13	70.90
IUUC-Pfo-097431	Poecilia formosa	89.91	7.00e-177	612.00
IUUC-Pab-097852	Pongo abelii	99.68	0.00e+00	659.00
IUUC-Pca-100496	Procavia capensis	91.19	9.00e-169	585.00
IUUC-Pva-103157	Pteropus vampyrus	98.50	2.00e-116	410.00
IUUC-Pgr-103416	Puccinia graminis	32.04	2.00e-13	70.50
IUUC-Rno-105928	Rattus norvegicus	99.37	0.00e+00	658.00
IUUC-Sha-107556	Sarcophilus harrisii	99.06	0.00e+00	653.00
IUUC-Sar-113208	Sorex araneus	99.68	0.00e+00	659.00
IUUC-Ssc-116011	Sus scrofa	99.37	0.00e+00	659.00
IUUC-Tgu-116882	Taeniopygia guttata	74.50	3.00e-73	267.00
IUUC-Tru-117987	Takifugu rubripes	89.59	2.00e-176	611.00
IUUC-Tsy-118785	Tarsius syrichta	99.37	0.00e+00	653.00
IUUC-Tni-120165	Tetraodon nigroviridis	89.27	6.00e-176	609.00
IUUC-Tbe-127920	Tupaia belangeri	99.00	2.00e-118	417.00
IUUC-Ttr-129160	Tursiops truncatus	99.05	0.00e+00	657.00
IUUC-Vpa-130629	Vicugna pacos	99.68	0.00e+00	659.00
IUUC-Xtr-131895	Xenopus tropicalis	95.27	0.00e+00	635.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence