iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
circBase	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	21411632; 23307929

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	2.10e-07	32.0	5	45
ULD/UDP/UFD/UBX	1.40e-19	71.5	569	645
ULD/UDP/UBQ/UBQ_Other	3.20e-09	37.6	110	169

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 1    sededkleqlve.MGF.dreealqaLraannnleaAveyLl 39
           +++e++l+ +++ +G+ + +ea++ L+++n++l aA++ ++
   Q: 5    MDREMILADFQAcTGIeNIDEAITLLEQNNWDLVAAINGVI 45
           689**********************************9875 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfveyllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++ ++l+iR+p+G++l+r+F +s++l+ +++fv+ ++++++d+F+L+s+fPrr++++ + +++l e +L+p+++l++
   Q: 569  AEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVA-SKGFPWDEFKLLSTFPRRDVTQLDPNKSLLEVNLFPQETLFL 645
           56799******************************.****************************************97 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL...eddktLadyglkdgstihll 70
           + ++ ++ s+tV+e+K+ +e +l ip+   ++++kG      ed   L++++l+ ++ +++l
   Q: 110  NVDVVLEDSCTVGEIKQILENELQIPVP--KMLLKGWKTgdvEDSTVLKSLHLPKNNSLYVL 169
           5566678999****************55..688887776666***************99987 PP

Organism

Mus musculus

Functional Description
(View)

Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain (By similarity). Specifically interacts with the cytoplasmic domain of FAS.

Protein Sequence
(Fasta)

MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSDFGGET 60
MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML DFRVEYRDRN VDVVLEDSCT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGGCGGA GGCGGCGGCC GGGGAGGAAG CGGAGGAGGC GGAGGCGGCT GTGGCGTTGG 60
CCCGCCTGCT CCTTCTCTCG CTTTCCCCGC CCCCGTCGGG TTTGCCGTGG CTGGAGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR033043--FAF1_UBX
IPR012336--Thioredoxin-like_fold
IPR006577--UAS
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50033--UBX

Pfam

PF00789--UBX

SMART

SM00594--UAS
SM00166--UBX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031072--F:heat shock protein binding
GO:0051059--F:NF-kappaB binding
GO:0019904--F:protein domain specific binding
GO:0019901--F:protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0006915--P:apoptotic process
GO:0008219--P:cell death
GO:0007253--P:cytoplasmic sequestering of NF-kappaB
GO:0010942--P:positive regulation of cell death
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0031334--P:positive regulation of protein complex assembly
GO:0030155--P:regulation of cell adhesion
GO:0042176--P:regulation of protein catabolic process

KEGG

mmu:14084

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002153	Ailuropoda melanoleuca	96.30	0.00e+00	1221.00
IUUC-Apl-004127	Anas platyrhynchos	89.81	0.00e+00	1127.00
IUUC-Aca-005188	Anolis carolinensis	89.17	0.00e+00	1121.00
IUUC-Ame-010696	Astyanax mexicanus	76.65	0.00e+00	867.00
IUUC-Bta-012965	Bos taurus	96.46	0.00e+00	1216.00
IUUC-Cel-018420	Caenorhabditis elegans	29.12	2.00e-29	124.00
IUUC-Cja-019128	Callithrix jacchus	95.71	0.00e+00	1234.00
IUUC-Cfa-021201	Canis familiaris	96.46	0.00e+00	908.00
IUUC-Cpo-021475	Cavia porcellus	96.05	0.00e+00	905.00
IUUC-Csa-024076	Chlorocebus sabaeus	96.46	0.00e+00	1219.00
IUUC-Cho-025067	Choloepus hoffmanni	82.90	0.00e+00	1052.00
IUUC-Cin-025663	Ciona intestinalis	42.94	2.00e-67	249.00
IUUC-Csv-025894	Ciona savignyi	34.24	5.00e-70	258.00
IUUC-Dre-027508	Danio rerio	74.52	0.00e+00	937.00
IUUC-Dno-029336	Dasypus novemcinctus	95.69	0.00e+00	1196.00
IUUC-Dor-030218	Dipodomys ordii	89.98	0.00e+00	1105.00
IUUC-Dme-031581	Drosophila melanogaster	32.78	1.00e-92	334.00
IUUC-Ete-032860	Echinops telfairi	74.12	0.00e+00	669.00
IUUC-Eca-034321	Equus caballus	97.34	0.00e+00	1050.00
IUUC-Eeu-034844	Erinaceus europaeus	74.12	2.00e-144	506.00
IUUC-Fca-036575	Felis catus	98.40	0.00e+00	729.00
IUUC-Fal-037128	Ficedula albicollis	90.17	0.00e+00	1147.00
IUUC-Gmo-038694	Gadus morhua	73.05	0.00e+00	898.00
IUUC-Gga-040826	Gallus gallus	90.48	0.00e+00	1154.00
IUUC-Gac-042125	Gasterosteus aculeatus	74.77	0.00e+00	966.00
IUUC-Ggo-045254	Gorilla gorilla	96.31	0.00e+00	1220.00
IUUC-Hsa-046722	Homo sapiens	96.15	0.00e+00	1219.00
IUUC-Itr-048149	Ictidomys tridecemlineatus	96.55	9.00e-102	362.00
IUUC-Lch-050312	Latimeria chalumnae	80.58	0.00e+00	670.00
IUUC-Loc-051990	Lepisosteus oculatus	80.79	0.00e+00	961.00
IUUC-Laf-054375	Loxodonta africana	97.35	0.00e+00	726.00
IUUC-Mcc-054627	Macaca mulatta	95.92	0.00e+00	1187.00
IUUC-Meu-056611	Macropus eugenii	70.85	2.00e-130	459.00
IUUC-Mga-059400	Meleagris gallopavo	88.17	0.00e+00	1128.00
IUUC-Mmr-060882	Microcebus murinus	95.99	0.00e+00	1185.00
IUUC-Mdo-061874	Monodelphis domestica	90.77	0.00e+00	1167.00
IUUC-Mpu-065713	Mustela putorius furo	95.90	0.00e+00	1181.00
IUUC-Mlu-068122	Myotis lucifugus	95.48	0.00e+00	1153.00
IUUC-Nle-069025	Nomascus leucogenys	95.85	0.00e+00	1209.00
IUUC-Opr-071089	Ochotona princeps	86.13	0.00e+00	1093.00
IUUC-Ont-072421	Oreochromis niloticus	74.40	0.00e+00	947.00
IUUC-Oan-073092	Ornithorhynchus anatinus	86.83	0.00e+00	845.00
IUUC-Ola-086497	Oryzias latipes	75.11	0.00e+00	958.00
IUUC-Oga-088854	Otolemur garnettii	95.99	0.00e+00	1207.00
IUUC-Oar-090120	Ovis aries	96.62	0.00e+00	1193.00
IUUC-Ptr-091554	Pan troglodytes	96.31	0.00e+00	1220.00
IUUC-Pan-091985	Papio anubis	96.00	0.00e+00	1190.00
IUUC-Psi-093548	Pelodiscus sinensis	90.09	0.00e+00	1082.00
IUUC-Pma-094123	Petromyzon marinus	52.45	1.00e-52	198.00
IUUC-Pfo-096729	Poecilia formosa	73.89	0.00e+00	947.00
IUUC-Pab-097810	Pongo abelii	96.46	0.00e+00	1222.00
IUUC-Pca-101079	Procavia capensis	88.80	0.00e+00	897.00
IUUC-Pva-102534	Pteropus vampyrus	88.31	0.00e+00	923.00
IUUC-Ptt-103866	Puccinia triticina	36.14	2.80e-01	30.40
IUUC-Rno-105127	Rattus norvegicus	98.86	0.00e+00	1133.00
IUUC-Sha-106667	Sarcophilus harrisii	92.20	0.00e+00	1023.00
IUUC-Ssl-108656	Sclerotinia sclerotiorum	24.56	2.50e-02	32.30
IUUC-Sar-113424	Sorex araneus	82.37	0.00e+00	649.00
IUUC-Ssc-115974	Sus scrofa	95.75	0.00e+00	1162.00
IUUC-Tgu-116495	Taeniopygia guttata	90.17	0.00e+00	1149.00
IUUC-Tru-118727	Takifugu rubripes	72.46	0.00e+00	927.00
IUUC-Tsy-118906	Tarsius syrichta	91.22	0.00e+00	1097.00
IUUC-Tni-119717	Tetraodon nigroviridis	74.85	0.00e+00	944.00
IUUC-Tbe-127849	Tupaia belangeri	82.44	0.00e+00	721.00
IUUC-Ttr-128660	Tursiops truncatus	92.18	0.00e+00	1149.00
IUUC-Vpa-130359	Vicugna pacos	96.85	0.00e+00	1195.00
IUUC-Xtr-132212	Xenopus tropicalis	82.49	0.00e+00	721.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence