iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.10e-09	38.3	29	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveik.d.vqpevfrallkFlYtgklden 68
           D+ l v++ +ffah+ vLaa S+  ++l+ +++++  + +l ++i+   ++p  + +ll++ Y+gk+ ++
   Q: 29   DMALSVDNHVFFAHRNVLAAVSPLVRSLIsSNDMKTAD-ELFITIDtSyLSPVTVDQLLDYFYSGKVVIS 97
           78999************************888888888.*******637*****************9876 PP

Organism

Homo sapiens

Functional Description
(View)

Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa.

Protein Sequence
(Fasta)

MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS PLVRSLISSN 60
DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRVHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCCCTGGT CAACCGCTCT GCAAACAACC ATCAATCTGA TCCCACAGGC CTGAGAAAGT 60
CTGCTCTCCA GTACCTGCTG CTGATCTGTT TCAGCCGACA AGAGGCACCA TGAAATTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0033150--C:cytoskeletal calyx
GO:0005634--C:nucleus
GO:0003779--F:actin binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007283--P:spermatogenesis

KEGG

hsa:881

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001471	Ailuropoda melanoleuca	93.54	0.00e+00	1167.00
IUUC-Aca-004588	Anolis carolinensis	60.14	0.00e+00	764.00
IUUC-Bta-012811	Bos taurus	91.50	0.00e+00	1117.00
IUUC-Cja-019280	Callithrix jacchus	96.10	0.00e+00	1149.00
IUUC-Cfa-021268	Canis familiaris	93.20	0.00e+00	1166.00
IUUC-Cpo-022358	Cavia porcellus	88.27	0.00e+00	1104.00
IUUC-Csa-023527	Chlorocebus sabaeus	97.45	0.00e+00	1147.00
IUUC-Dno-029107	Dasypus novemcinctus	93.20	0.00e+00	1167.00
IUUC-Dor-030337	Dipodomys ordii	88.44	0.00e+00	1088.00
IUUC-Ete-032606	Echinops telfairi	93.03	0.00e+00	1165.00
IUUC-Eca-034273	Equus caballus	86.10	0.00e+00	1021.00
IUUC-Eeu-035355	Erinaceus europaeus	93.20	0.00e+00	1165.00
IUUC-Fca-036204	Felis catus	93.71	0.00e+00	1163.00
IUUC-Ggo-045558	Gorilla gorilla	98.98	0.00e+00	1217.00
IUUC-Itr-048395	Ictidomys tridecemlineatus	93.88	0.00e+00	1133.00
IUUC-Lch-050104	Latimeria chalumnae	54.95	5.00e-179	620.00
IUUC-Laf-054528	Loxodonta africana	93.88	0.00e+00	1175.00
IUUC-Mcc-055129	Macaca mulatta	97.79	0.00e+00	1170.00
IUUC-Mpo-057374	Magnaporthe poae	34.33	3.00e-05	43.50
IUUC-Mmr-061547	Microcebus murinus	94.05	0.00e+00	1158.00
IUUC-Mdo-061998	Monodelphis domestica	81.80	0.00e+00	1020.00
IUUC-Mmu-064007	Mus musculus	93.03	0.00e+00	1103.00
IUUC-Mpu-066791	Mustela putorius furo	93.88	0.00e+00	1171.00
IUUC-Nle-069625	Nomascus leucogenys	96.60	0.00e+00	1189.00
IUUC-Opr-070410	Ochotona princeps	93.03	0.00e+00	1147.00
IUUC-Oan-073301	Ornithorhynchus anatinus	73.42	0.00e+00	913.00
IUUC-Ocu-074131	Oryctolagus cuniculus	92.86	0.00e+00	1145.00
IUUC-Oga-088044	Otolemur garnettii	94.22	0.00e+00	1159.00
IUUC-Oar-090106	Ovis aries	91.84	0.00e+00	1149.00
IUUC-Ptr-091169	Pan troglodytes	99.66	0.00e+00	1227.00
IUUC-Psi-093438	Pelodiscus sinensis	69.22	0.00e+00	892.00
IUUC-Pab-097818	Pongo abelii	97.79	0.00e+00	1206.00
IUUC-Pva-102448	Pteropus vampyrus	91.39	0.00e+00	701.00
IUUC-Rno-105305	Rattus norvegicus	93.03	0.00e+00	1103.00
IUUC-Sha-106813	Sarcophilus harrisii	82.82	0.00e+00	996.00
IUUC-Ssc-116432	Sus scrofa	92.35	0.00e+00	1140.00
IUUC-Tbe-127443	Tupaia belangeri	93.03	0.00e+00	1161.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence