iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	KPID	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	24286022

Organism

Homo sapiens

Functional Description
(View)

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

Protein Sequence
(Fasta)

MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE GEEHQLPPPP PGSFWNVESA 60
AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC 120

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Nucleotide Sequence
(Fasta)

CGAGCGCGGC GCCCTTGAGC TGCACCGCGG CGCAGGTTTG CGAGCCGACT TGTCAGCCGG 60
CCAAGAAAAG GAAGCTCCGT CCCTTCCCGC TCACCCGGCT TCCCCACCCC TTGTACTCTA 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR025136--DUF4071
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR013761--SAM/pointed
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF13281--DUF4071
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005829--C:cytosol
GO:0009897--C:external side of plasma membrane
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:1902911--C:protein kinase complex
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0019903--F:protein phosphatase binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0007257--P:activation of JUN kinase activity
GO:0000186--P:activation of MAPKK activity
GO:0097190--P:apoptotic signaling pathway
GO:0070301--P:cellular response to hydrogen peroxide
GO:1902170--P:cellular response to reactive nitrogen species
GO:0071356--P:cellular response to tumor necrosis factor
GO:0072577--P:endothelial cell apoptotic process
GO:0045087--P:innate immune response
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254--P:JNK cascade
GO:0000165--P:MAPK cascade
GO:0038066--P:p38MAPK cascade
GO:0043065--P:positive regulation of apoptotic process
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043507--P:positive regulation of JUN kinase activity
GO:0045663--P:positive regulation of myoblast differentiation
GO:1901216--P:positive regulation of neuron death
GO:1900745--P:positive regulation of p38MAPK cascade
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0097300--P:programmed necrotic cell death
GO:0006468--P:protein phosphorylation
GO:0034976--P:response to endoplasmic reticulum stress
GO:0002931--P:response to ischemia
GO:0016032--P:viral process
GO:0042060--P:wound healing

KEGG

hsa:4217

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002318	Ailuropoda melanoleuca	97.04	0.00e+00	2360.00
IUUC-Apl-003713	Anas platyrhynchos	89.16	0.00e+00	2080.00
IUUC-Aca-005331	Anolis carolinensis	87.79	0.00e+00	2094.00
IUUC-Ame-011158	Astyanax mexicanus	74.14	0.00e+00	1856.00
IUUC-Bta-012770	Bos taurus	95.12	0.00e+00	2466.00
IUUC-Cja-019656	Callithrix jacchus	98.54	0.00e+00	2565.00
IUUC-Cfa-020488	Canis familiaris	96.07	0.00e+00	2458.00
IUUC-Cpo-022516	Cavia porcellus	94.95	0.00e+00	2339.00
IUUC-Csa-023104	Chlorocebus sabaeus	99.51	0.00e+00	2359.00
IUUC-Cho-024379	Choloepus hoffmanni	89.99	0.00e+00	1234.00
IUUC-Dre-028836	Danio rerio	75.48	0.00e+00	1888.00
IUUC-Dno-029842	Dasypus novemcinctus	94.30	0.00e+00	2207.00
IUUC-Dor-030990	Dipodomys ordii	95.50	0.00e+00	1939.00
IUUC-Ete-032693	Echinops telfairi	85.11	0.00e+00	2000.00
IUUC-Eca-033337	Equus caballus	95.77	0.00e+00	2322.00
IUUC-Eeu-034602	Erinaceus europaeus	80.28	0.00e+00	2060.00
IUUC-Fca-035954	Felis catus	96.48	0.00e+00	1939.00
IUUC-Fal-037358	Ficedula albicollis	88.65	0.00e+00	2108.00
IUUC-Gmo-038836	Gadus morhua	78.53	0.00e+00	1764.00
IUUC-Gga-040443	Gallus gallus	86.73	0.00e+00	2241.00
IUUC-Gac-041634	Gasterosteus aculeatus	75.06	0.00e+00	1939.00
IUUC-Ggo-045263	Gorilla gorilla	97.90	0.00e+00	2519.00
IUUC-Itr-048449	Ictidomys tridecemlineatus	95.66	0.00e+00	1107.00
IUUC-Lch-050213	Latimeria chalumnae	78.70	0.00e+00	1810.00
IUUC-Loc-051829	Lepisosteus oculatus	72.01	0.00e+00	1881.00
IUUC-Laf-053538	Loxodonta africana	95.55	0.00e+00	2501.00
IUUC-Mcc-054776	Macaca mulatta	99.27	0.00e+00	2617.00
IUUC-Mga-059636	Meleagris gallopavo	88.61	0.00e+00	2138.00
IUUC-Mmr-061323	Microcebus murinus	97.16	0.00e+00	2490.00
IUUC-Mdo-062146	Monodelphis domestica	91.36	0.00e+00	2338.00
IUUC-Mmu-064022	Mus musculus	94.13	0.00e+00	2430.00
IUUC-Mpu-066531	Mustela putorius furo	93.18	0.00e+00	2473.00
IUUC-Mlu-068181	Myotis lucifugus	90.97	0.00e+00	2400.00
IUUC-Nle-069758	Nomascus leucogenys	99.67	0.00e+00	2361.00
IUUC-Opr-070531	Ochotona princeps	88.02	0.00e+00	1468.00
IUUC-Ont-072014	Oreochromis niloticus	77.57	0.00e+00	1915.00
IUUC-Oan-073169	Ornithorhynchus anatinus	93.56	0.00e+00	2250.00
IUUC-Ocu-074050	Oryctolagus cuniculus	92.65	0.00e+00	2169.00
IUUC-Ola-086941	Oryzias latipes	80.34	0.00e+00	1553.00
IUUC-Oga-088796	Otolemur garnettii	96.22	0.00e+00	2476.00
IUUC-Oar-090445	Ovis aries	96.89	0.00e+00	2303.00
IUUC-Ptr-090846	Pan troglodytes	99.56	0.00e+00	2620.00
IUUC-Pan-091986	Papio anubis	99.34	0.00e+00	2620.00
IUUC-Psi-093805	Pelodiscus sinensis	89.09	0.00e+00	2241.00
IUUC-Pfo-097301	Poecilia formosa	73.99	0.00e+00	1934.00
IUUC-Pab-097662	Pongo abelii	99.55	0.00e+00	2517.00
IUUC-Pca-100755	Procavia capensis	95.88	0.00e+00	729.00
IUUC-Pva-102280	Pteropus vampyrus	86.89	0.00e+00	2269.00
IUUC-Rno-105547	Rattus norvegicus	92.89	0.00e+00	2414.00
IUUC-Sha-106859	Sarcophilus harrisii	90.83	0.00e+00	2289.00
IUUC-Sar-113714	Sorex araneus	84.30	0.00e+00	1944.00
IUUC-Tgu-117116	Taeniopygia guttata	87.32	0.00e+00	2179.00
IUUC-Tru-118088	Takifugu rubripes	76.63	0.00e+00	1949.00
IUUC-Tsy-119616	Tarsius syrichta	91.79	0.00e+00	2014.00
IUUC-Tni-120284	Tetraodon nigroviridis	75.54	0.00e+00	1904.00
IUUC-Tbe-127900	Tupaia belangeri	95.12	0.00e+00	851.00
IUUC-Ttr-128294	Tursiops truncatus	85.31	0.00e+00	2147.00
IUUC-Vpa-130470	Vicugna pacos	87.52	0.00e+00	2066.00
IUUC-Xtr-132396	Xenopus tropicalis	75.67	0.00e+00	1979.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence