iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021988

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAKN02026467

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010208.3	ENSCPOT00000010301.2	ENSCPOP00000009169.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-135	450.3	537	869

Active Site

Position(s)	Description	Evidence
838	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSILWIKEN---NLEECGLELFFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 869
           *********************************************************************96 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MASASSSRPG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IVLNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCTG CCAGCTCCAG CCGGCCAGGA GTGGCTCTCC CTTTTGAGAA ATCTCAGCTT 60
ACCCTGAAAG GTGAGTGGCT CGTGTCACAT GCATGTCACT GGAGGTCCAG CTTCGTGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	95.07	0.00e+00	1630.00
IUUC-Apl-003912	Anas platyrhynchos	76.51	0.00e+00	1235.00
IUUC-Aca-004291	Anolis carolinensis	80.41	0.00e+00	1427.00
IUUC-Bta-013231	Bos taurus	94.48	0.00e+00	1586.00
IUUC-Cel-018299	Caenorhabditis elegans	67.01	0.00e+00	832.00
IUUC-Cja-019455	Callithrix jacchus	95.29	0.00e+00	1670.00
IUUC-Cfa-021017	Canis familiaris	95.75	0.00e+00	1622.00
IUUC-Csa-023549	Chlorocebus sabaeus	95.29	0.00e+00	1680.00
IUUC-Cin-025212	Ciona intestinalis	72.15	0.00e+00	876.00
IUUC-Dre-028513	Danio rerio	91.59	0.00e+00	1135.00
IUUC-Dno-028976	Dasypus novemcinctus	94.95	0.00e+00	1664.00
IUUC-Dor-030176	Dipodomys ordii	93.14	0.00e+00	1515.00
IUUC-Dme-032041	Drosophila melanogaster	68.14	0.00e+00	870.00
IUUC-Eca-033949	Equus caballus	95.52	0.00e+00	1635.00
IUUC-Eeu-034529	Erinaceus europaeus	87.84	0.00e+00	1374.00
IUUC-Fca-036236	Felis catus	95.17	0.00e+00	1670.00
IUUC-Fal-036948	Ficedula albicollis	77.54	0.00e+00	1323.00
IUUC-Gmo-038842	Gadus morhua	88.89	0.00e+00	1068.00
IUUC-Gga-040617	Gallus gallus	79.76	0.00e+00	1436.00
IUUC-Gac-041338	Gasterosteus aculeatus	69.39	0.00e+00	1249.00
IUUC-Ggo-045278	Gorilla gorilla	95.98	0.00e+00	1692.00
IUUC-Hsa-046148	Homo sapiens	95.98	0.00e+00	1692.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	98.32	0.00e+00	1123.00
IUUC-Lch-050663	Latimeria chalumnae	78.48	0.00e+00	1390.00
IUUC-Loc-052604	Lepisosteus oculatus	76.40	0.00e+00	1318.00
IUUC-Laf-053944	Loxodonta africana	94.94	0.00e+00	1656.00
IUUC-Mcc-055655	Macaca mulatta	95.40	0.00e+00	1681.00
IUUC-Meu-055953	Macropus eugenii	79.70	0.00e+00	1385.00
IUUC-Mga-060190	Meleagris gallopavo	80.36	0.00e+00	1439.00
IUUC-Mmr-060896	Microcebus murinus	96.18	0.00e+00	1637.00
IUUC-Mdo-062536	Monodelphis domestica	90.60	0.00e+00	1607.00
IUUC-Mmu-064017	Mus musculus	95.29	0.00e+00	1645.00
IUUC-Mpu-066608	Mustela putorius furo	93.35	0.00e+00	1582.00
IUUC-Mlu-067623	Myotis lucifugus	92.77	0.00e+00	1592.00
IUUC-Nle-069496	Nomascus leucogenys	94.03	0.00e+00	1644.00
IUUC-Opr-071054	Ochotona princeps	84.22	0.00e+00	1426.00
IUUC-Ont-071279	Oreochromis niloticus	73.55	0.00e+00	1286.00
IUUC-Oan-073512	Ornithorhynchus anatinus	87.37	0.00e+00	1481.00
IUUC-Ocu-074271	Oryctolagus cuniculus	95.22	0.00e+00	1618.00
IUUC-Ola-087237	Oryzias latipes	66.99	0.00e+00	1155.00
IUUC-Oga-088164	Otolemur garnettii	96.55	0.00e+00	1689.00
IUUC-Oar-089698	Ovis aries	94.83	0.00e+00	1597.00
IUUC-Ptr-091306	Pan troglodytes	94.71	0.00e+00	1662.00
IUUC-Pan-092814	Papio anubis	91.86	0.00e+00	1591.00
IUUC-Pfo-096709	Poecilia formosa	72.35	0.00e+00	1277.00
IUUC-Pab-098494	Pongo abelii	90.62	0.00e+00	1596.00
IUUC-Pca-100596	Procavia capensis	83.69	0.00e+00	1385.00
IUUC-Pva-103154	Pteropus vampyrus	90.61	0.00e+00	1567.00
IUUC-Rno-104954	Rattus norvegicus	94.72	0.00e+00	1407.00
IUUC-Sha-106781	Sarcophilus harrisii	91.17	0.00e+00	1657.00
IUUC-Ssc-116307	Sus scrofa	82.74	0.00e+00	1441.00
IUUC-Tgu-116530	Taeniopygia guttata	75.00	0.00e+00	1180.00
IUUC-Tru-118287	Takifugu rubripes	89.63	0.00e+00	1070.00
IUUC-Tsy-119097	Tarsius syrichta	83.10	0.00e+00	1234.00
IUUC-Tni-120801	Tetraodon nigroviridis	71.06	0.00e+00	1208.00
IUUC-Tbe-127793	Tupaia belangeri	84.37	0.00e+00	1444.00
IUUC-Ttr-128275	Tursiops truncatus	91.38	0.00e+00	1554.00
IUUC-Uma-129332	Ustilago maydis	46.53	7.00e-143	501.00
IUUC-Xtr-132866	Xenopus tropicalis	82.54	0.00e+00	1135.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence