iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000061345.5	ENSDART00000136640.2	ENSDARP00000112571.1
ENSDARG00000061345.5	ENSDART00000139582.2	ENSDARP00000122529.1
ENSDARG00000061345.5	ENSDART00000087364.4	ENSDARP00000081798.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-132	442.7	534	866

Active Site

Position(s)	Description	Evidence
835	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 534  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 621
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   d+ee+g++l f ++ eilg++++++Lk +Gen+ Vt++NkeeY+ l+++
   Q: 622  GFTLPFYKRMLNKKPTLKDLESIDPEFYNSIMWVKEN---DLEECGVELYFAQDMEILGKVTTHQLKDDGENELVTQDNKEEYIGLLTD 707
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqFv
   Q: 708  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLNDWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQFV 795
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y++ e+l+ekLl+Aieet+gF++
   Q: 796  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKNLEQLREKLLFAIEETEGFGQ 866
           *********************************************************************96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAAASVSQSA SIQAIEKSQL TLKVLSAKPQ SPKLPNRHSR LSSFVEVTAD GLSSETKKTG 60
KRSGHLELQW NEDLTLNVTP QSRLDLKVWS CHTLRKELLG SATIDLLDTL RTHDGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGTTCGTG GCCCCAGTTC TAGTAAGTCT TGCTACCGAG TTTTTTGATC TTGTTCTTGT 60
ATTTTTTTGC TAAAGTCTAA CGTTAGTTTG TAAAGTTATT GTTTCTGAGC CTTGTCTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	91.00	0.00e+00	1134.00
IUUC-Apl-003912	Anas platyrhynchos	71.05	0.00e+00	1129.00
IUUC-Aca-004291	Anolis carolinensis	73.53	0.00e+00	1296.00
IUUC-Bta-013231	Bos taurus	91.53	0.00e+00	1125.00
IUUC-Cja-019455	Callithrix jacchus	74.37	0.00e+00	1291.00
IUUC-Cfa-021017	Canis familiaris	74.66	0.00e+00	1292.00
IUUC-Cpo-021988	Cavia porcellus	74.22	0.00e+00	1285.00
IUUC-Csa-023549	Chlorocebus sabaeus	74.25	0.00e+00	1301.00
IUUC-Dno-028976	Dasypus novemcinctus	75.06	0.00e+00	1296.00
IUUC-Dor-030176	Dipodomys ordii	91.53	0.00e+00	1119.00
IUUC-Eca-033949	Equus caballus	72.63	0.00e+00	1271.00
IUUC-Eeu-034529	Erinaceus europaeus	91.00	0.00e+00	966.00
IUUC-Fca-036236	Felis catus	91.18	0.00e+00	1143.00
IUUC-Fal-036948	Ficedula albicollis	93.01	0.00e+00	1143.00
IUUC-Gmo-038842	Gadus morhua	93.47	0.00e+00	1112.00
IUUC-Gga-040617	Gallus gallus	91.98	0.00e+00	1159.00
IUUC-Gac-041338	Gasterosteus aculeatus	92.65	0.00e+00	1133.00
IUUC-Ggo-045278	Gorilla gorilla	74.43	0.00e+00	1303.00
IUUC-Hsa-046148	Homo sapiens	74.71	0.00e+00	1303.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	91.42	0.00e+00	1050.00
IUUC-Lch-050663	Latimeria chalumnae	75.83	0.00e+00	1353.00
IUUC-Loc-052604	Lepisosteus oculatus	79.13	0.00e+00	1389.00
IUUC-Laf-053944	Loxodonta africana	91.18	0.00e+00	1142.00
IUUC-Mcc-055655	Macaca mulatta	74.25	0.00e+00	1302.00
IUUC-Meu-055953	Macropus eugenii	79.34	0.00e+00	971.00
IUUC-Mga-060190	Meleagris gallopavo	91.81	0.00e+00	1159.00
IUUC-Mmr-060896	Microcebus murinus	74.07	0.00e+00	1300.00
IUUC-Mdo-062536	Monodelphis domestica	74.05	0.00e+00	1309.00
IUUC-Mmu-064017	Mus musculus	91.53	0.00e+00	1130.00
IUUC-Mpu-066608	Mustela putorius furo	72.33	0.00e+00	1234.00
IUUC-Mlu-067623	Myotis lucifugus	72.94	0.00e+00	1253.00
IUUC-Nle-069496	Nomascus leucogenys	72.79	0.00e+00	1258.00
IUUC-Opr-071054	Ochotona princeps	91.53	0.00e+00	1117.00
IUUC-Ont-071279	Oreochromis niloticus	83.18	0.00e+00	1435.00
IUUC-Oan-073512	Ornithorhynchus anatinus	72.37	0.00e+00	1271.00
IUUC-Ocu-074271	Oryctolagus cuniculus	73.52	0.00e+00	1289.00
IUUC-Ola-087237	Oryzias latipes	92.33	0.00e+00	1114.00
IUUC-Oga-088164	Otolemur garnettii	91.71	0.00e+00	1128.00
IUUC-Oar-089698	Ovis aries	91.53	0.00e+00	1125.00
IUUC-Ptr-091306	Pan troglodytes	73.91	0.00e+00	1279.00
IUUC-Pan-092814	Papio anubis	71.44	0.00e+00	1228.00
IUUC-Pfo-096709	Poecilia formosa	79.84	0.00e+00	1389.00
IUUC-Pab-098494	Pongo abelii	91.70	0.00e+00	1125.00
IUUC-Pca-100596	Procavia capensis	82.26	0.00e+00	996.00
IUUC-Pva-103154	Pteropus vampyrus	91.76	0.00e+00	1081.00
IUUC-Rno-104954	Rattus norvegicus	74.74	0.00e+00	1155.00
IUUC-Sha-106781	Sarcophilus harrisii	74.03	0.00e+00	1313.00
IUUC-Ssc-116307	Sus scrofa	86.51	0.00e+00	1067.00
IUUC-Tgu-116530	Taeniopygia guttata	86.95	0.00e+00	1038.00
IUUC-Tru-118287	Takifugu rubripes	93.32	0.00e+00	1110.00
IUUC-Tni-120801	Tetraodon nigroviridis	77.05	0.00e+00	1311.00
IUUC-Tbe-127793	Tupaia belangeri	81.83	0.00e+00	971.00
IUUC-Ttr-128275	Tursiops truncatus	91.36	0.00e+00	1123.00
IUUC-Xtr-132866	Xenopus tropicalis	87.87	0.00e+00	1102.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence