iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033949

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

JN712754

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000006481.1	ENSECAT00000007141.1	ENSECAP00000005168.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.40e-136	453.3	537	869

Active Site

Position(s)	Description	Evidence
838	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLSKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 869
           *********************************************************************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTCTTGCA GTTTCCTGGT GATGACATGG CATCTGCCAG CTCCAGCCGG GCAGGAGTGG 60
CCCTGCCTTT TGAGAAGTCT CAGCTCACTT TGAAAGGTGA GTGGCACAGT GAGAAGTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

KEGG

ecb:100067291

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	97.25	0.00e+00	1658.00
IUUC-Apl-003912	Anas platyrhynchos	76.99	0.00e+00	1244.00
IUUC-Aca-004291	Anolis carolinensis	81.13	0.00e+00	1444.00
IUUC-Bta-013231	Bos taurus	96.44	0.00e+00	1621.00
IUUC-Cel-018299	Caenorhabditis elegans	67.01	0.00e+00	832.00
IUUC-Cja-019455	Callithrix jacchus	95.86	0.00e+00	1685.00
IUUC-Cfa-021017	Canis familiaris	97.70	0.00e+00	1653.00
IUUC-Cpo-021988	Cavia porcellus	95.52	0.00e+00	1664.00
IUUC-Csa-023549	Chlorocebus sabaeus	96.09	0.00e+00	1693.00
IUUC-Dre-028513	Danio rerio	91.59	0.00e+00	1136.00
IUUC-Dno-028976	Dasypus novemcinctus	96.79	0.00e+00	1689.00
IUUC-Dor-030176	Dipodomys ordii	92.44	0.00e+00	1503.00
IUUC-Eeu-034529	Erinaceus europaeus	88.86	0.00e+00	1385.00
IUUC-Fca-036236	Felis catus	97.36	0.00e+00	1700.00
IUUC-Fal-036948	Ficedula albicollis	78.55	0.00e+00	1338.00
IUUC-Gmo-038842	Gadus morhua	88.89	0.00e+00	1068.00
IUUC-Gga-040617	Gallus gallus	80.20	0.00e+00	1437.00
IUUC-Gac-041338	Gasterosteus aculeatus	70.04	0.00e+00	1253.00
IUUC-Ggo-045278	Gorilla gorilla	96.32	0.00e+00	1699.00
IUUC-Hsa-046148	Homo sapiens	96.32	0.00e+00	1699.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	97.76	0.00e+00	1119.00
IUUC-Lch-050663	Latimeria chalumnae	78.14	0.00e+00	1385.00
IUUC-Loc-052604	Lepisosteus oculatus	75.60	0.00e+00	1310.00
IUUC-Laf-053944	Loxodonta africana	96.78	0.00e+00	1684.00
IUUC-Mcc-055655	Macaca mulatta	95.98	0.00e+00	1695.00
IUUC-Meu-055953	Macropus eugenii	80.39	0.00e+00	1387.00
IUUC-Mga-060190	Meleagris gallopavo	80.70	0.00e+00	1439.00
IUUC-Mmr-060896	Microcebus murinus	96.30	0.00e+00	1637.00
IUUC-Mdo-062536	Monodelphis domestica	91.74	0.00e+00	1620.00
IUUC-Mmu-064017	Mus musculus	95.17	0.00e+00	1642.00
IUUC-Mpu-066608	Mustela putorius furo	94.38	0.00e+00	1600.00
IUUC-Mlu-067623	Myotis lucifugus	94.03	0.00e+00	1618.00
IUUC-Nle-069496	Nomascus leucogenys	94.03	0.00e+00	1644.00
IUUC-Opr-071054	Ochotona princeps	84.22	0.00e+00	1427.00
IUUC-Ont-071279	Oreochromis niloticus	74.22	0.00e+00	1282.00
IUUC-Oan-073512	Ornithorhynchus anatinus	88.06	0.00e+00	1500.00
IUUC-Ocu-074271	Oryctolagus cuniculus	95.45	0.00e+00	1623.00
IUUC-Ola-087237	Oryzias latipes	69.32	0.00e+00	1231.00
IUUC-Oga-088164	Otolemur garnettii	96.67	0.00e+00	1685.00
IUUC-Oar-089698	Ovis aries	96.78	0.00e+00	1630.00
IUUC-Ptr-091306	Pan troglodytes	95.06	0.00e+00	1665.00
IUUC-Pan-092814	Papio anubis	92.32	0.00e+00	1602.00
IUUC-Pfo-096709	Poecilia formosa	73.75	0.00e+00	1282.00
IUUC-Pab-098494	Pongo abelii	90.50	0.00e+00	1597.00
IUUC-Pca-100596	Procavia capensis	84.40	0.00e+00	1390.00
IUUC-Pva-103154	Pteropus vampyrus	91.80	0.00e+00	1573.00
IUUC-Rno-104954	Rattus norvegicus	94.72	0.00e+00	1414.00
IUUC-Sha-106781	Sarcophilus harrisii	91.63	0.00e+00	1655.00
IUUC-Ssc-116307	Sus scrofa	85.51	0.00e+00	1464.00
IUUC-Tgu-116530	Taeniopygia guttata	76.23	0.00e+00	1196.00
IUUC-Tru-118287	Takifugu rubripes	89.46	0.00e+00	1067.00
IUUC-Tsy-119097	Tarsius syrichta	83.23	0.00e+00	1228.00
IUUC-Tni-120801	Tetraodon nigroviridis	67.71	0.00e+00	1128.00
IUUC-Tbe-127793	Tupaia belangeri	84.25	0.00e+00	1439.00
IUUC-Ttr-128275	Tursiops truncatus	92.18	0.00e+00	1567.00
IUUC-Uma-129332	Ustilago maydis	46.53	2.00e-143	503.00
IUUC-Xtr-132866	Xenopus tropicalis	82.54	0.00e+00	1134.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence